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ISSN 0016-3813 (Impreso)

2004, Número 3

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Gac Med Mex 2004; 140 (3)


Fosforilación de tau y enfermedad de Alzheimer

García T, Jay D

Idioma: Español
Referencias bibliográficas: 52
Paginas: 329-334
Archivo PDF: 528.67 Kb.


RESUMEN

Tau forma parte importante del citoesqueleto en neuronas; estabilizando microtúbulos, manteniendo la forma celular y como vía de transporte axonal. Sin embargo, por mecanismos desconocidos, tau sufre modificaciones importantes como son fosforilación anormal debida a la actividad desequilibrada de varias cinasas y fosfatasas, afectando su función biológica normal. Bajo estas circunstancias tau comienza a agregarse originando complejos protéicos denominados desarreglos neurofibrilares (NFTS) que son hallazgos histopatológicos característicos de la enfermedad de Alzheimer junto con las placas seniles. Esta revisión esta enfocada principalmente a describir la estructura de tau y la participación de diferentes cinasas en su regulación.


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