2015, Number 1
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AbanicoVet 2015; 5 (1)
Profiles of acute phase proteins in medicine as biomarkers in dogs and cats
Cardiel-Hernández B, Gutiérrez-Bañuelos H, Díaz-García L, Polin- Raygoza L, Espinoza-Canales A, Gutiérrez-Piña F, Meza- López C, Muro-Reyes A
Language: Spanish
References: 68
Page: 51-62
PDF size: 102.31 Kb.
ABSTRACT
Acute phase proteins (APF) has been used as biomarkers of inflammation, infection or
trauma, particularly in human medicine; therefore, already has research in the area of
veterinary medicine. In this topic, there have been some recent studies in both pets and
farm animals. The dominant biomarker as an indicator of disease have been mainly
protein C-reactive, haptoglobin, amyloid serum, isoform of amyloid serum A-3 and
glycoproteins. The response rate of these biomarkers or APF differs by species; but in all cases they can assist in the diagnosis of disease, monitoring periods of
convalescence, and/or animal welfare indicators.
REFERENCES
ANDERSSON M, Sevelius E. Abnormal microheterogeneity of haptoglobin in serum from dogs with various diseases. Veterinary Record. 2001; 148:14–17.
ANDERSSON M., Stenstrom M, Vatne M, Sevelius E, Jonsson L. Disease- related variations of the glycosylation of haptoglobin in the dog. Journal of Comparative Pathology. 1998; 119:227–238.
ATEMEZEM A., Mbemba E, Vassy R, Slimani H, Saffar L, Gattegno L. Human a1-acid glycoprotein binds to CCR5 expressed on the plasma membrane of human primary macrophages. Biochemical Journal. 2001; 356:121–128.
BATHEN-NOETHEN A, Carlson R, Menzel D, Mischke R, Tipold A. Concentrations of acute-phase proteins in dogs with steroid responsive meningitis-arteritis. Journal of Veterinary Internal Medicine. 2008; 22:1149–1156.
BAYRAMLI G, Ulutas B. Acute phase protein response in dogs with experimentally induced gastric mucosal injury. Veterinary Clinical Pathology 2008; 37:312–316.
CALDIN M, Tasca S, Carli E, Bianchini S, Furlanello T, Martinez-Subiela S, Ceron JJ. Serum acute phase protein concentrations in dogs with hyperadrenocorticism with and without concurrent inflammatory conditions. Veterinary Clinical Pathology. 2009; 38:63– 68.
CECILIANI F, Grossi C, Giordano A, Pocacqua V, Paltrinieri S. Decreased sialylation of the acute phase protein a1-acid glycoprotein in feline infectious peritonitis (FIP). Veterinary Immunology and Immunopathology. 2004; 99:229–236.
CERON JJ, Eckersall PD, Martinez-Subiela S. Acute phase proteins in dogs and cats; current knowledge and future perspectives. Veterinary Clinical Pathology. 2005; 34:85– 99.
CORREA SS, Mauldin GN, Mauldin GE, Mooney SC. Serum alpha 1-acid glycoprotein concentration in cats with lymphoma. Journal of the American Animal Hospital Association 2001; 37:153–158.
DABROWSKI R, Kostro K, Lisiecka U, Szczubial M, Krakowski L. Usefulness of Creactive protein, serum amyloid A component, and haptoglobin determinations in bitches with pyometra for monitoring early post- ovariohysterectomy complications. Theriogenology. 2009; 72:471–476.
DUTHIE S, Eckersall PD, Addie DD, Lawrence CE, Jarrett O. Value of alpha 1-acid glycoprotein in the diagnosis of feline infectious peritonitis. Veterinary Record. 1997; 141: 299–303.
ECKERSALL PD, Harvey MJ, Ferguson J, Renton JP, Nickson D, Boyd J. Acute phase proteins in canine pregnancy (Canis familiaris). Journal of Reproduction and Fertility. 1993; 47(Suppl.):159–164.
FRANCINE C, Da Silva A, Breno VC, França RT, Costa MM, Duarte MF, da Silva CB, Mazzanti CMA, Monteiro SG, Lopes STA. Serum proteinogram, acute phase proteins and immunoglobulins in dogs experimentally infected with Rangelia vitalii. Veterinary Parasitology. 2013; 192:137-142.
FOURNIER T, Medjoubi NN, Porquet D. 1-Acid glycoprotein. Biochim. Biophys. Acta. 2000; 1482:157-171.
GEBHARDT C, Hirschberger J, Rau S, Arndt G, Krainer K, Schweigert FJ, Brunnberg L, Kaspers B, Kohn B. Use of C-reactive protein to predict outcome in dogs with systemic inflammatory response syndrome or sepsis. Journal of Veterinary Emergency and Critical Care. 2009; 19:450–458.
GIORDANO A, Spagnolo V, Colombo A, Paltrinieri S. Changes in some acute phase protein and immunoglobulin concentrations in cats affected by feline infectious peritonitis or exposed to feline coronavirus infection. The Veterinary Journal. 2004; 167:38–44.
GRAAF TW, Van-der-Stelt ME, Anbergen MG, Van-Dijk W. Inflammation-induced expression of sialyl LewisX-containing glycan structures on 1-acid glycoprotein (orosomucoid) in human será. J. Exp. Med. 1993; 177:657666.
HARVEY JW, West CL. Prednisolone-induced increases in serum alpha-2- globulin and haptoglobin concentration in dogs. Veterinary Pathology. 1987; 24:90–92.
HOCHEPIED T, Berger FG, Baumann H, Libert C. Alpha(1)-acid glycoprotein: an acute phase protein with inflammatory and immunomodulating properties. Cytokine and Growth Factor Reviews. 2003; 14:25–34.
HOLM JL, Rozanski EA, Freeman LM, Webster CRL. C-reactive protein concentrations in canine acute pancreatitis. Journal of Veterinary Emergency and Critical Care. 2004; 14:183–186.
HORI Y, Indou A, Yamaguchi S, Uechi M. The time course of C-reactive protein in a dog suffering acute pancreatitis. Journal of the Japan Veterinary Medical Association. 2006; 59:619–622.
JERGENS, AE, Schreiner CA, Frank DE, Niyo Y, Ahrens FE, Eckersall PD, Benson TJ, Evans R. A scoring index for disease activity in canine inflammatory bowel disease. Journal of Veterinary Internal Medicine. 2003; 17:291– 297.
JOHNSON, KH, Sletten K, Hayden DW, O’Brien TD, Rossow KD, Westermark P. AA amyloidosis in Chinese Shar-pei dogs – immunohistochemical and amino-acidsequence analyses. Amyloid. International Journal of Experimental and Clinical Investigation. 1995; 2:92–99.
KANN RK, Seddon JM, Henning J, Meers J. Acute phase proteins in healthy and sick cats. Research in Veterinary Science. 2012; 93:649–654.
KANN RK, Seddon, JM, Kyaw-Tanner MT, Henning J, Meers J. Association between feline immunodeficiency virus (FIV) plasma viral RNA load, concentration of acute phase proteins and disease severity. The Veterinary Journal. 2014; doi: 10.1016/j.tvjl.2014.01.023
KAJIKAWA, T, Furuta A, Onishi T, Tajima T, Sugii S. Changes in concentrations of serum amyloid A, alpha(1)-acid glycoprotein, haptoglobin and C-reactive protein in feline sera due to induced inflammation and surgery. Journal of Veterinary Medical Science. 1999; 68;91–98.
KARLSSON I, Wernersson S, Ambrosen A, Kindahl H, Södersten F, Wang L, Hagman R. Increased concentrations of C-reactive protein but not high-mobility group box 1 in dogs with naturally occurring sepsis. Veterinary Immunology and Immunopathology; 2013; 156:64-72.
KISILEVSKY R, Benson MD, Axelrad MA, Boudreau L. The effect of a liver protein synthesis inhibitor on plasma SAA levels in a model of accelerated amyloid deposition. Lab. Invest. 1979; 41:206–210.
KJELGAARD-HANSEN M, Jensen AL, Houser GA, Jessen LR, Kristensen AT. Use of serum C-reactive protein as an early marker of inflammatory activity in canine type II immune-mediated polyarthritis: case report. Acta Veterinaria Scandinavica. 2006; 48:9.
KNAPP A, Schrodl W, Grevel V, Oechtering G. C-reactive protein (CRP) serumconcentration in dogs with impaired postoperative wound healing. Tierärztliche Praxis Ausgabe Kleintiere Heimtiere. 2009; 37:21–27.
KORMAN RM, Cerón JJ, Knowles TG, Barker EN, Eckersall PD, Tasker S. Acute phase response to Mycoplasma haemofelis and ‘Candidatus Mycoplasma haemominutum’ infection in FIV-infected and non-FIV-infected cats. The Veterinary Journal. 2012; 193:433–438.
LINDE-SIPMAN JS, Niewold TA, Tooten PCJ, Neijs-Backer M, Gruys E. Generalized AA-amyloidosis in Siamese and Oriental cats. Veterinary Immunology and Immunopathology. 1997; 56:1-10.
LOWRIE M, Penderis J, Eckersall PD, McLaughlin M, Mellor D, Anderson TJ. The role of acute phase proteins in diagnosis and management of steroid-responsive meningitis arteritis in dogs. The Veterinary Journal. 2009a; 182:125–130.
LOWRIE M, Penderis J, McLaughlin M, Eckersall PD, Anderson TJ. Steroid responsive meningitis-arteritis: a prospective study of potential disease markers, prednisolone treatment, and long-term outcome in 20 dogs (2006– 2008). Journal of Veterinary Internal Medicine. 2009b; 23:862–870.
MACKIEWICZ A, Pawlowski T, Mackiewicz-Pawlowska A, Wiktorowicz K, Mackiewicz S. 1987. Microheterogeneity forms of 1-acid glycoprotein as indicators of rheumatoid arthritis activity. Clin. Chim. Acta, 163:185-190.
MARTÍNEZ-SUBIELA S, García-Martínez J, Tvarijonaviciute A, Tecles F, Caldin M, Bernal L, Cerón J. Urinary C reactive protein levels in dogs with leishmaniasis at different stages of renal damage. Research in Veterinary Science. 2013; 95:924-929.
MARTINEZ-SUBIELA S, Strauss-Ayali D, Cerón J, Baneth G. Acute phase protein response in experimental canine leishmaniosis. Veterinary Parasitology. 2011; 180:197- 202.
MARTINEZ-SUBIELA S, Tecles F, Eckersall PD, Ceron JJ. Serum concentrations of acute phase proteins in dogs with leishmaniasis. Veterinary Record. 2002; 150:241– 244.
MARTINEZ-SUBIELA S, Ginel PJ, Ceron, JJ. Effects of different glucocorticoid treatments on serum acute phase proteins in dogs. Veterinary Record. 2004; 154:814– 817.
MCGROTTY YL, Arteaga A, Knottenbelt CM, Ramsey IK, Eckersall PD. Haptoglobin concentrations in dogs undergoing trilostane treatment for hyperadrenocorticism. Veterinary Clinical Pathology. 2005; 34:255–258.
MERLO A, Rezende BCG, Franchini ML, Simoes DMN, Lucas SRR. Serum C-reactive protein concentrations in dogs with multicentric lymphoma undergoing chemotherapy. Journal of the American Veterinary Medical Association. 2007; 230:522–526.
MERLO A, Rezencle BCG, Franchini ML, Monteiro PRG, Lucas SRR. Serum amyloid A is not a marker for relapse of multicentric lymphoma in dogs. Veterinary Clinical Pathology. 2008; 37:79–85.
MIRANDA-RIBERA A, Lecchi C, Bronzo, V, Scaccabarozzi L, Sartorelli P, Franciosi F, Ceciliani F. Down-regulatory effect of alpha 1-acid glycoprotein on bovine neutrophil degranulation. Comparative Immunology Microbiology and Infectious Diseases. 2010; 33:291–306.
MISCHKE R, Waterston M, Eckersall PD. Changes in C-Reactive protein and haptoglobin in dogs with lymphatic neoplasia. The Veterinary Journal. 2007; 174:188– 192.
MITCHELL KD, Kruth SA, Wood RD, Jefferson B. Serum acute phase protein concentrations in dogs with autoimmune hemolytic anaemia. Journal of Veterinary Internal Medicine 2009; 23:585–591.
MURATA H, Shimada N, Yoshioka M. Current research on acute phase proteins in veterinary diagnosis: an overview. The Veterinary Journal. 2004; 168:28–40.
NIELSEN L, Toft N, Eckersall PD, Mellor DJ, Morris JS. Serum C-reactive protein concentration as an indicator of remission status in dogs with multicentric lymphoma. Journal of Veterinary Internal Medicine. 2007; 21:1231–12
GRUYS E. Familial amyloidosis in cats: Siamese and Abyssinian AA proteins differ in primary sequence and pattern of deposition. Amyloid-Journal of Protein Folding Disorders. 1999; 6:205–209.
OHNO K, Yokoyama Y, Nakashima K, Setoguchi A, Fujino Y, Tsujimoto H. C-reactive protein concentration in canine idiopathic polyarthritis. Journal of Veterinary Medical Science. 2006; 68:1275–1279.
PALTRINIERI S. The feline acute phase reaction. The Veterinary Journal. 2008; 177:26- 35.
PALTRINIERI S, Giordano A, Tranquillo V, Guazzetti S. Critical assessment of the diagnostic value of feline a1-acid glycoprotein for feline infectious peritonitis using likelihood ratios approach. Journal of Veterinary Diagnostic Investigation. 2007a; 19:266–272.
PALTRINIERI S, Metzger C, Battilani M, Pocacqua V, Gelain ME, Giordano A. Serum a1-acid glycoprotein (AGP) concentration in non-symptomatic cats with feline coronavirus (FCoV) infection. Journal of Feline Medicine and Surgery. 2007b; 9:271– 277.
PETERSEN HH, Nielsen JP, Heegaard PMH. Application of acute phase protein measurement in veterinary clinical chemistry. Veterinary Research. 2004; 35:163–187.
PLANELLAS M, Bassols A, Siracusa C, Saco Y, Gimenez M, Pato R, Pastor J. Evaluation of serum haptoglobin and C-reactive protein in dogs with mammary tumors. Veterinary Clinical Pathology. 2009; 38:348–352.
POCACQUA V, Provasi E, Paltrinieri S, Gelain E, Comunian C, Ceciliani F. Glycan moiety modifications of feline a1-acid glycoprotein in retrovirus (FIV, FeLV) affected cats. Veterinary Immunology and Immunopathology. 2005; 107:17–26.
ROSSI G, Capitani L, Ceciliani F, Restelli L, Paltrinieri S. Hyposialylated a1-acid glycoprotein inhibits phagocytosis of feline neutrophils. Research in Veterinary Science. 2013; 95:465–471.
RUSH JE, Lee ND, Freeman LM, Brewer B. C-reactive protein concentration in dogs with chronic valvular disease. Journal of Veterinary Internal Medicine. 2006; 20:635– 639.
SAUNDERS AB, Smith BE, Fosgate GT, Suchodolski JS, Steiner JM. Cardiac troponin I and C-reactive protein concentrations in dogs with severe pulmonic stenosis before and after balloon valvuloplasty. Journal of Veterinary Cardiology. 2009; 11:9–16.
SCHAER DJ, Roberti FS, Schoedon G, Schaffner A. Induction of the CD163-dependent haemoglobin uptake by macrophages as a novel anti-inflammatory action of glucocorticoids. British Journal of Haematology. 2002; 119:239–243.
SELTING KA, Ogilvie GK, Lana SE, Fettman MJ, Mitchener KL, Hansen RA, Richardson KL, Walton JA, Scherk MA. Serum alpha 1-acid glycoprotein concentrations in healthy and tumor-bearing cats. Journal of Veterinary Internal Medicine. 2000; 14:503–506.
TAKASHI T, Koichi O, Yuko GH, Hajime T. Feline serum amyloid A protein as an endogenous Toll-like receptor 4 agonist. Veterinary Immunology and Immunopathology. 2013; 155:190– 196.
TECLES F, Spiranelli E, Bonfanti U, Ceron JJ, Paltrinieri S. Preliminary studies of serum acute-phase protein concentrations in hematologic and neoplastic diseases of the dog. Journal of Veterinary Internal Medicine. 2005; 19:865–870.
TILG H, Vannier E, Vachino G, Dinarello C, Mier JJW. Antiinflammatory properties of hepatic acute phase proteins: preferential induction of interleukin 1 (IL-1) receptor antagonist over IL-1 beta synthesis by human peripheral blood mononuclear cells. Journal of Experimental Medicine. 1993; 178:1629–2636.
TURNER GA. N-glycosylation of serum proteins in disease and its investigation using lectins. Clin. Chim. Acta. 1992; 208:149-171.
VANNUCCHI CI, Mirandola RM, Oliveira CM. Acute-phase protein profile during gestation and diestrous: proposal for an early pregnancy test in bitches. Animal Reproduction Science. 2002; 74:87–99.
VEIGA APM, Price CA, De-Oliveira ST, Dos-Santos AP, Campos R, Barbosa PR, Gonzalez FHD. Association of canine obesity with reduced serum levels of C-reactive protein. Journal of Veterinary Diagnostic Investigation. 2008; 20:224– 228.
WAGENER FA, Eggert A, Boerman OC, Oyen WJ, Verhofstad A, Abraham NG, Adema G, Van-Kooyk Y, De-Witte T, Figdor CG. Heme is a potent inducer of inflammation in mice and is counteracted by heme oxigenase. Blood. 2001; 98:18021811.
YULE TD, Roth MB, Dreier K, Johnson AF, Palmer-Densmore M, Simmons K, Fanton R. Canine parvovirus vaccine elicits protection from the inflammatory and clinical consequences of the disease. Vaccine. 1997; 15:720–729.