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2014, Number 2

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Rev Cubana Invest Bioméd 2014; 33 (2)

Analysis of the effect of salt intake on the development of obesity

Cerna CJ, Díaz RMI, Cervantes KVH, Marín CA, Hernández EVM, Montero CSA

Language: Spanish
References: 18
Page: 119-128
PDF size: 242.24 Kb.


ABSTRACT

Introduction: intestinal transport of glucose and many amino acids is performed by the SGLT1 cotransporter only when the latter is bound to the sodium ion. Salt contributes a sodium ion per molecule ingested. Human salt intake is often tenfold the required amount, and is generally accompanied by a carbohydrate-rich diet. The present study is based on the assumption that reducing the amount of salt in foods is a simple weight-loss strategy.
Objective: study the effect of salt on glucose absorption dynamics and the effect of a diet rich in carbohydrates and salt on the development of obesity in Wistar rats.
Methods: to corroborate the hypothesis, an evaluation was conducted of the effect of salt on intestinal glucose absorption, based on glucose tolerance curves with and without salt. An analysis was also made of whether a diet rich in carbohydrates and salt leads to the development of obesity in Wistar rats.
Results: experiments showed that salt intake does not influence intestinal glucose absorption or the development of obesity in Wistar rats.
Conclusion: sodium naturally recirculating from the cytoplasm of enterocytes to the intestinal lumen keeps the SGLT1 glucose cotransporter saturated and at all times ensures the transport of the glucose ingested in the diet.


REFERENCES

  1. World Health Organization. Controlling the global obesity epidemic. [Acceso: 8 de mayo de 2013]. Disponible en: http://www.who.int/nut/obs.htm.

  2. Spiegelman BM, Choy L, Hotamisligil GS, Graves RA, Tontonoz P. Regulation of adipocyte gene expresión in differentiation and sindromes of obesity/diabetes. J Biol Chem 1993;268:6823-6826.

  3. Zhang Y, Proenca R, Maffei M, Barone M, Leopold L, Friedman JM. Positional cloning of the mouse obese gene and its human homologue. Nature 1994;372:425-32.

  4. Hotamisligil GS, Shargill NS, Spiegelman BM. Adipose expression of tumor necrosis factor-a: direct role in obesity-linked insulin resistance. Science 1993;259:87-91.

  5. Shimomura I, Funahashi T, Takahashi M, Maeda K, Kotani K, Nakamura T, et al. Enhanced expression of PAI-1 in visceral fat : Possible contributor to vascular disease in obesity. Nat Med 1996;2:800-3.

  6. Maeda K, Okubo K, Shimomura I, Mizuno K, Matsuzawa Y, Matsubara K, et al. analysis of an expression profile of genes in the human adipose tissue. Gene 1997;190:227-35.

  7. Steppan CM, Bailey ST, Bhat S, Brown EJ, Banerjee RR, Wright CM, et al. The hormone resistin links obesity to diabetes. Nature 2001;409:207-12.

  8. Maeda K, Okubo K, Shimomura I, Funahashi T, Matsuzawa Y, Matsubara K. cDNA cloning and expression of a novel adipose-specific collagen-like factor, apMI (adipose most abundant gene transcript 1). Biochem Biophys Res Commun 1996;221:286-289.

  9. Roden M, Bernroider E. Hepatic glucose metabolism-its role in health and disease. Best Pract Res Clin Endocrinol Metab 2003;17(3):365-383.

  10. Reuss L: One-hundred years of injury: the mechanism of glucose absorption in the intestine. Annu Rev Physiol 2000;62:939.

  11. Ferraris RP, Diamond J. Regulation of intestinal sugar transport. Physiol Rev 1997;77(1):257-302.

  12. Depósitos de documentos de la FAO. Departamento de agricultura. Nutrición humana en el mundo en desarrollo. [Acceso: 8 de mayo de 2013]. Disponible en: http://www.fao.org/DOCREP/006/W0073S/w0073s0d.htm

  13. Reunión Técnica de la OMS sobre la Reducción del Consumo de Sal en la Población. El cloruro sódico alimentario: efectos adversos. París. ISBN 978 92 4 159537 7 (Clasificación de la NLM: QU 145), 2006.

  14. Flowers MT, Ntambi JM. Stearoyl-CoA Desaturase and its Relation to High-Carbohydrate Diets and Obesity. Biochim Biophys Acta 2009;1791(2):85-91.

  15. Guyton AC, Hall JE. Tratado de fisiología médica. 11ª ed. Madrid: Elsevier; 2006.

  16. Zeuthen T, Stein WD. Cotransport of salt and water in membrane proteins: membrane proteins as osmotic engines. J Membr Biol 1994;137(3):179-95.

  17. Montoreano R. Manual de Fisiología y biofísica para estudiantes de medicina. [Acceso: 8 de mayo de 2013]. Disponible en: http://www.fundabiomed.fcs.uc.edu.ve/cap51.pdf

  18. Regulation of active ion transport in the small intestine. Field M. Ciba Found Symp. 1976;(42):109-27.




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