2007, Number 3
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Dermatología Cosmética, Médica y Quirúrgica 2007; 5 (3)
Hepatitis C Virus (HCV) and Its Link with the Skin
Navarro JBR
Language: Spanish
References: 66
Page: 149-154
PDF size: 125.61 Kb.
ABSTRACT
In case of chronic hepatitis it is accepted that the most common cause of this ailment is the infection provoked
by the hepatitis C virus (hcv), which is acquired by parenteral exposures or sexual transmission. The
ailment can be accompanied by many extrahepatic manifestations, of which the ones involving the skin stand
out, an important organ as it is where the virus can enter, and be a place for viral replication or appear in several
clinical manifestations in presence of the hcv.
REFERENCES
Crowson, A.N.; G. Nuovo, C. Ferri, C.M. Magro, “The Dermatopathologic Manifestations of Hepatitis C Infection: a Clinical, Histological, and Molecular Assessment of 35 Cases”, Hum. Pathol., 2003, 34, pp. 573-579.
Handrick, W.; P. Nenoff, H. Muller, W. Knofler, “Infections Caused by Piercing and Tattoos. A Review”, Wien Med. Wochenschr., 2003, 153, pp. 194-1997.
Haley, R.W.; R.P. Fisher, “Commercial Tattooing As a Potentially Important Source of Hepatitis C Infection”, Medicine, 2001, 80, pp. 134-151.
Poljacki, M.; Z. Gajinov, M. Ivkov, M. Matic, Z. Golusin, “Skin Diseases and Hepatitis Virus C Infection”, Med. Pregl., 2000, 53, pp. 141-145.
Medina, J.; R. García-Buey, Moreno-Otero, “Hepatitis C Virus Related Extrahepatic Disease Aetiopathogenesis and Management”, Aliment. Pharmacol. Ther., 2004, 20, pp. 129-141.
Podanyi, B.; G. Lengyel, J. Harsing, K. Becker, A. Horvath, “Skin Diseases Associated with Chronic Hepatitis C”, J. Eur. Acad. Dermatol. Venereol., 2003,17, pp. 365-366.
Ortiz-Movilla, M.; P. Lazaro, E. Rodriguez-Iñigo, J. Bartolome, I. Longo, M. Lecona, M. Pardo, V. Carreño, “Hepatitis C Virus Replicates in Sweat Glands and is Released into Sweat in Patients with Chronic Hepatitis C”, Med. Virol. 2002, 68, pp. 529-536.
Erkek, E.; O. Bozdogan, A.L. Olut, “Hepatitis C Virus Prevalence in Lichen Planus: Examination of Lesional and Normal Skin of Hepatitis C Virus-Infected Patients with Lichen Planus for the Presence of Hepatitis C Virus RNA”, Clin. Exp. Dermatol., 2001, 26, pp. 540-544.
Licata, A.; G. Pietrosi, A. Rizzo, L. Pasta, L. Pagliaro, “Disseminated Non-Hodgkin’s Lymphoma and Chronic Hepatitis C: A Case Report”, Ann. Ital. Med. Int., 2003, 18, pp. 246-249.
Cordel, N.; O. Chosidow, C. Frances, “Cutaneous Disorders Associated with Hepatitis C Virus Infection”, Ann Med Intern., 2000, 151, pp. 46-52.
Dega, H.; C. Frances, N. Dupin, C. Lebre, A. Simantov, C. Callot, J.L. Laporte, C. Blot, P. Opolon, T. Poynard, O. Chosidow, “Pruritis and Hepatitis C Virus”, Ann Dermatol Venereol 1998; 125, pp. 9-12.
Podanyi, B., A. Kiss, P. Kaposi Novak, C. Paska, G. Lengyel, M. Horanyi, Z. Schaff, A. Horvath, “Hepatitis C Virus Rna in the Skin Eruption from Patients with Prurigo and Chronic Hepatitis C”, Orv. Hetil. 2004, 145, pp. 2371-2374.
Cacoub, P., C. Renou, E. Rosenthal, P. Cohen, I. Loury, V. Loustaud Ratti, A. Yamamoto M., Camproux A.C., P. Hausfater, L. Musset, P. Veyssier, Raguin G., J.C. Piette, “Extrahepatic Manifestations Associated with Hepatitis C Virus Infection. A Prospective Multicenter Study of 321 Patients”, Medicine, 2000, 79, pp. 47-56.
El-Serag, H.B.; H. Hampel, C. Yeh, L. Rabeneck, “Extrahepatic Manifestations of Hepatitis C among United States Male Veterans”, Hepatology, 2002, 36, pp. 1439-1345.
Cacoub, P., T. Poynard, P. Ghillani, F. Charlotte, M. Olivi, J.C. Piette, P. Opolon, “Extrahepatic Manifestations of Chronic Hepatitis C”, Arthritis. Rheum, 1999, 42, pp. 2204-2212.
Bondi, E.E; B.V. Jegasothy, G.S. Lazarus, “Dermatología diagnóstico y tratamiento”, Médica Panamericana, Buenos Aires, Argentina, 1993, pp. 193-194.
Pyrsopoulos, N.T.; K.R. Reddy, “Extrahepatic Manifestations of Chronic Viral Hepatitis”, Curr. Gastroenterol. Rep., 2001, 3, pp. 71-78.
Francés, C.; S. Barete, M.S. Doutre, M. Beylot-Barry, “Vasculitis Cutanées: Physiopathologie, Aspects Anatomocliniques, Classification”, Encyl. Med. Chir. Paris. Dermatologie, 98-562-A-10, 2003.
Francés, C., “Livedo”, Encyl. Med. Chir. Paris. Dermatologie; 98-552-A-10, 2000.
20.Fitzpatrick, T.B.; R.A. Johnson, M.K. Poland, D. Suurmond, K. Wolff, Atlas de dermatología clínica, México, Interamericana McGraw- Hill, 1994, pp. 524-527.
Barnadas, M.A.; E. Perez, I. Gich, J.M. Llobet, J. Ballarin, F. Calero, C. Facundo, A. Alomar, “Diagnostic, Prognostic and Pathogenic Value of the Direct Immunofluorescence Test in Cutaneous Leukocytoclastic Vasculitis”, Int. J. Dermatol., 2004, 43, pp. 19-26.
Cruz-Rojo, J.; A. Fontanellas, M.J. Moran-Jimenez, S. Navarro- Ordoñez, M. Gracia--Bravo, M. Mendez, M.C. Munoz-Rivero, R.E. de Salamanca, “Precipitating Aggravating Factors of Porphyria Cutanea Tarda in Spanish Patients”, Cell. Mol. Biol., 2002, 48, pp. 845-852.
R., Nocente; M. Ceccanti, G. Bertazzoni, G. Cammarota, N.G. Silveri, G. Gasbarrini, “HCV Infection and Extrahepatic Manifestations”, Hepatogastroenterology, 2003, 52, pp. 1149--1154.
24.Navarro, J.R.; V.A. Feria., H.Q. Navarro, “El melanocito en el vitiligo”, Dermatología Rev. Mex., 2005, 49, pp. 59-68.
Arican, O.; S. Sasmaz, O.F. Kokoglu, “Role of Hepatitis B and C in the Aetiopathogenesis of Vitiligo”, J. Dermatol., 2004, 31, pp. 506-507.
Guilhou, J.J., “Psoriasis: Diagnostic et Etiopathogenie”, Encycl. Méd. Chir. Dermatologie, 98-190-A-10, 2000.
Krengel, S. ; B. Tebbe, S. Goerdt, M. Stoffler-Meilicke, C.E. Orfanos, “Hepatitis C Virus-Associated Dermatoses: a Review”, Hautarzl., 1999, 50, pp. 629-636.
Chouela, E.; A. Abeldano, J. Panneta, M. Ducard, V. Neglia, S. Sookoian, M. Kina, G. Castano, F. Vereytou, B. Frider, “Hepatitis C Virus Antibody (Anti-HCV): Prevalence in Psoriasis”, Int. J. Dermatol., 1996, 35, pp. 797-799.
Granel, B. ; J. Serratrice, J. Rey, C. Bouvier, C. Weiller-Merli, P. Disdier, J.F. Pellissier, P.J. Weiller, “Chronic Hepatitis C Virus Infection Associated with a Generalized Granuloma Annulare”, J. Am. Acad. Dermatol., 2000, 43, pp. 918, 919.
Khanna, V.J.; S. Shieh, J. Benjamin, S. Somach, M.T. Zaim, W. Dorner Jr., M. Shill, G.S. Wood, “Necrolytic Acral Erythema Associated with Hepatitis C: Effective Treatment with Interferon Alpha And Zinc”, Arch. Dermatol., 2000, 136, pp. 755-757.
Abdallah, MA.; M.Y. Ghozzi, H.A. Monib, A.M. Hafez, K.M. Hiatt, B.R. Smoller, T.D. Horn, “Necrolytic Acral Erythema: A Cutaneus Sign of Hepatitis C Virus Infection”, J. Am. Acad. Dermatol., 2005, 52, pp. 247-251.
Taga, M.; T. Abe, S. Nishimura, H. Kimura, M. Oki, M. Nojima,, H. Tanaka, S. Matsumoto, K. Imai, “A Case of Sjögren’s Syndrome Associated with Chronic Hepatitis C and Sarcoidosis”, Nihon Rinsho Meneki Gakkai Kaishi, 2003, 26, pp. 336-340.
Ramos-Casals, M.; V. Loustaud-Ratti, S. De Vita, M. Zeher, J.A. Bosch, E. Toussirot, F. Medina, J. Rosas, J.M. Anaya, J. Font, “Sjögren Syndrome Associated with Hepatitis C Virus: a Multicenter Analysis of 137 Cases”, Medicine, 2005, 84, pp. 81-89.
Soufir, N.; V. Descamps, , B. Crickx, V. Thibault, A. Cosnes, P.A. Becherel, P. Wolkenstein, I. Bournerias, P. De La Salmoniere, C. Picard, J.C. Roujeau, J.C. Piette, S. Belaich, J. Revuz, C. Frances, “Hepatitis C Virus Infection in Cutaneous Polyarteritis Nodosa: a Retrospective Study of 16 Cases”, Arch. Dermatol., 1999, 135, pp. 1001-1002.
Boulinguez, S.; P. Bernard, J.P. Lacour, T. Nicot, C. Bedane, J.P. Ortonne, J.M. Bonnetblanc Bullous, “Lichen Sclerosis with Chronic Hepatitis C Virus Infection”, Br. J. Dermatol., 1997, 137, pp. 474-475.
Shearer, C.M.; J.M. Jackson, J.P. Callen, “Symmetric Polyarthritis with Livedo Reticularis: A Newly Recognized Manifestation of Hepatitis C Virus Infection”, J. Am. Acad. Dermatol., 1997, 37, pp. 659-661.
Mazzone, A.; G. Stefano, C. Chiara, “Hemangiodermatitis Associated with Chronic Hepatitis C Virus Infection”, Mayo Clin. Proc., 1996, 71, pp. 1124-1125.
Fiore, G.; F. Giacovazzo, M. Giacovazzo, “HCV and Dermatomyositis: Report of 5 Cases of Dermatomyositis in Patients with HCV Infection”, Riv. Eur. Sci Med. Farmacol., 1996, 18, pp. 197-201.
Neri, S.; C. Raciti, G. D’Angelo, D. Ierna, C.M. Bruno, “Hyde’s Prurigo Nodularis and Chronic HVC Hepatitis”, J. Hepatol., 1998, 28, pp. 161-164.
40.Cecchi, R.; A. Giomi, F. Tuci, L. Bartoli, G. Seghieri, “Pityriasis Rubra Pilaris, Lichen Planus, Alopecia Universalis and Vitiligo in a Patient with Chronic Viral Hepatitis C”, Dermatology, 1994, 188, pp. 239-240.
Gulati, S.; P. Mathur, D. Saini, R. Mannan, V. Kaira, “Erythema Annulare Centrifugum with Autoimmune Hepatitis”, Indian J. Pediatr., 2004, 71, pp. 541-542.
Lazaro, P.; J. Olalquiaga, J. Bartolome, N. Ortiz-Movilla, E. Rodriguez-Iñigo, M. Pardo, M. Lecona, M. Pico, I. Longo, P. García-Morras, V. Carreno, “Detection of Hepatitis C Virus RNA and Core Protein in Keratinocytes from Patients with Cutaneous Lichen Planus and Chronic Hepatitis C”, J. Invest. Dermatol., 2002, 119, pp. 798-803.
Kurokawa, M.; T. Hidaka, H. Sasaki, I. Nishikata, K. Morishita, M. Setoyama, “Analysis of Hepatitis C Virus (HCV) RNA in the Lesions of Lichen Planus in Patients with Chronic Hepatitis C: Detection of Anti-Genomic As Well As Genomic-Strand HCV RNAS in Lichen Planus Lesions”, J. Dermatol. Sci., 2003, 32, pp. 65-70.
Houman, M.H.; I. Ben Ghorbel, M. Lamloum, M. Khanfir, S. B’Chir, M. Miled, “Leukocytoclastic Vasculitis, Cryoglobulinemia and Medullary Aplasia Associated with Hepatitis C”, Tunis Med., 2001,79, pp. 398-400.
Viguier, M.; J. Rivet, F. Agbalika, E. Kerviler, P. Brice, L. Dubertret, H. Bachelez, “B-Cell Lymphomas Involving the Skin Associated with Hepatitis C Virus Infection”, Int. J. Dermatol., 2002, 41, pp. 577- 582.
46.Mahboob, A.; T.S. Haroon, Z. Iqbal, F. Iqbal, A.K. Butt, “Frequency of Anti-HCV Antibodies in Patients with Lichen Planus”, J. Coll. Physicians Surg. Pak., 2003, 13, pp. 248-251.
Sansonno, D; F. Dammacco, “Hepatitis C Virus, Cryoglobulinaemia, and Vasculitis: Immune Complex Relations”, Lancet. Infect. Dis., 2005, 5, pp. 227-236.
Ferri, C.; M. Sebastiani, D. Giuggioli, M. Cazzato, G. Longombardo, A. Antonelli, R. Puccini, C. Michelassi, A.L. Zignego, “Mixed Cryoglobulinemia: Demographic, Clinical, and Serologic Features and Survival in 231 Patients”, Semin. Arthritis Rheum., 2004, 33, pp. 355-374.
Girard, C.; Guillot B., C. Biron, T. Lavabre-Bertrand, R. Navarro, D. Bessis, “Digital Skin Necrosis in Congenital Afibrinogenaemia Associated with Hepatitis C Virus Infection, Mixed Cryoglobulinaemia and Anticardiolipin Antibodies”, Acta Derm. Venereol., 2005, 85, pp. 56-59.
Jackson, J.M.; J.P. Callen, “Scarring Alopecia and Sclerodermatous Changes of the Scalp in a Patient with Hepatitis C Infection”, J. Am. Acad. Dermatol., 1998, 39, pp. 824-826.
Pawlotski, J.M.; D. Dhumeaux, M. Bagot, “Hepatitis C Virus in Dermatology. A Review”, Arch. Dermatol. 1995, 131, pp. 1185-1193.
Lindenmann I.A., “Virus Interference: the Interferon”, Proc. R. Soc. Lond., 1957, 147, p. 258.
Brown, C.K.; J.M. Kiekwood, “Adjuvant Therapy for Melanoma”, en Sober A.J.; F.G. Haluska, Skin Cancer, Ontario, BC Delker Inc., 2001, pp. 206-224.
Cottoni, F.; S. Bolognini, A. Deplano, G. Garrucciu, N.E. Manzoni, G. Careddu, M.A. Montesu, A. Tocco, A. Lissia, A. Solinas, “Skin Reaction in Antiviral Therapy for Chronic Hepatitis C: a Role for Polyethylene Glycol Interferon?”, Acta Derm. Venereol., 2004, 84, pp. 120-123.
Cacoub, P.; D. Saadoun, N. Limal, D. Sene, O. Lidove, J.C. Piette, “PEGylated Interferon Alpha-2b and Ribavirin Treatment in Patients with Hepatitis C Virus Related Systemic Vasculitis”, Arthritis Rheum., 2005, 52, pp. 911-915.
Harden, D.; H. Skelton, K.J. Smith, “Lichen Planus Associated with Hepatitis C Virus: No Viral Transcripts Are Found in the Lichen Planus, and Effective Therapy for Hepatitis C Virus Does Not Clear Lichen Planus”, J. Am. Acad. Dermatol., 2003, 49, pp. 847-852.
Simsek, H.; C. Savas, H. Akkiz, H. Telatar, “Interferon-Induced Vitiligo in a Patient with Chronic Viral Hepatitis C Infection”, Dermatology, 1996, 193, pp. 65-66.
Berger, L.; V. Descamps, Y. Marck, L. Dehen, M. Grossin, B. Crickx P. Marcellin, S. Belaich, “Alpha Interferon Induced Eczema in Atopic Patients Infected by Hepatitis C Virus: 4 Case Reports”, Ann. Dermatol. Venereol., 200, 127, pp. 51-55.
59.Willems, M.; K. Munte, J.M. Vrolijk, J.C. Den Hollander, M. Bohm, M.H. Kemmeren, R.A. De Man, J.T. Brouwer, “Hyperpigmentation During Interferon Alpha Therapy for Chronic C Virus Infection”, Br. J. Dermatol., 2003, 149, pp. 390-394.
60.Gurguta, C.; C. Kauer, U. Bergholz, E. Formann, P. Steindl-Munda, P. Ferenci, “Tongue and Skin Hyperpigmentation During Peg- Interferon-Alpha/Ribavirin Therapy in Dark-Skinned Non- Caucasian Patients with Chronic Hepatitis C”, Am. J. Gastroenterol., 2006, 101, pp. 197-198.
Choi, H.K.; F.S. Thome, T. Orlandini, E. Barros, “Increased Skin Pigmentation in Patients with Chronic Renal Failure Undergoing Hemodialysis Infected with the Hepatitis C Virus”, Rev. Assoc. Med. Bras., 2003, 49, pp. 24-28.
Cacoub, P.; A. Sbai, C. Frances, C. Genesti, P. Hausfater, J.C. Piette, “Systemic Sarcoidosis During Interferon-Alpha Therapy for Chronic Hepatitis C Virus Infection”, Gastroenterol. Clin. Biol., 2000, 24, pp. 364-366.
Ramos-Casals, M.; J. Mana, N. Nardi, P. Brito-Zeron, A. Xaubet, J.M. Sanchez-Tapias, R. Cervera, J. Font, “Sarcoidosis in Patients with Chronic Hepatitis C Virus Infection: Analysis of 68 Cases”, Medicine, 2005, 84, pp. 69-80.
Monti, M..; L.L. Mancini, R. Ceriani, I. Hendrickx, M. Guizzardi. “Iatrogenic Kaposi’s Sarcoma and HCV Infection”, J. Eur. Acad. Dermatol. Venereol., 2004, 18, pp. 191-193.
Sparsa, A.; V. Loustaud-Ratti, S. Alain, E. Liozon, C. Bedane, E. Vidal, “Skin Necrosis Alter Injection of Peg-Interferon Alpha 2b in an HCV-Infected Patient”, Acta Derm. Venereol. 2004; 84, pp. 415-416.
66.Kasahara, A.; A. Hirade, N. Tomita, H. Iwahashi, A. Imagawa, N. Ohguro, S. Yamamoto, E. Mita, N. Hayashi,. “Vogt-Koyanagui- Harada Disease Occurring During Interferon Alpha Therapy for Chronic Hepatitis C”, J. Gastroenterol., 2004, 39, pp. 1106-1109.