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2007, Number 4

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Dermatología Cosmética, Médica y Quirúrgica 2007; 5 (4)

Butenafine. A review

López GI, Bonifaz A

Language: Spanish
References: 47
Page: 211-217
PDF size: 226.69 Kb.


ABSTRACT

Butenafine is a benzylamine derivative and similar to allylamines, it inhibits biosynthesis of ergosterol, blocking the squalene epoxidation. It remains at the stratum corneum for 72 hours and has anti-inflammatory as well as antifungal activity against dermatophytes and other filamentous fungi. It is fungistatic against Candida Albicans and Malassezia Furfur with a low minimum inhibitory concentration (MIC), compared to other topical antimycotics. Butenafine is available for topical administration in 1% cream formulation. It has shown to have superior antifungal activity in tinea pedis, corporis, and cruris compared with topical clotrimazole and terbinafine. It also has proved to be effective in seborrheic dermatitis caused by Malassezia Sp. Our experience dermatophytoses treated with topical Butenafine, a clinical and mycological cure was achieved in 19/20 cases (95%) with no adverse reactions.


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