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2014, Number 4

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Ortho-tips 2014; 10 (4)

Scientific evidence of growth factors in orthopedic surgery and traumatology

Fernández-Fairen M, Gutiérrez-Gómez J, Hernández-Vaquero D, Torres-Pérez AI, Sueiro-Fernández J

Language: Spanish
References: 100
Page: 235-257
PDF size: 248.67 Kb.


ABSTRACT

The systematic and critical review of existing literature regarding the growth factors used specifically (GF) and nonspecific like him platelet rich plasma (PRP) to discern the level of scientific evidence, risk/benefit and possible grade of recommendation of therapeutic procedures in which currently used for sports medicine. Growth factors (GF) in specific bone morphogenic proteins (BMP’s) extracted from white blood formula and are commercially available recombinantly using genomic medicine. Other forms of obtaining growth factors are by centrifugation of blood concentrates are obtained where multiple growth factors such as platelet rich plasma (PRP), growth factors are beneficial in chronic tendon injuries, except anterior cruciate ligament (ACL), osteoarthritis of the knee, long bone nonunions, posterolateral lumbar fusions. There is insufficient evidence to recommend the use of growth factors in muscle injuries, cervical spine arthrodesis, arthroplasty or pediatric pathologies such as congenital pseudarthrosis of tibia or bone elongation of achondroplasia evidence. Each case is unique and the profit depends on the specific way in which it is obtained and applied each growth factor. Therefore, we do not recommend widespread use of growth factors for treatment of bone, muscle and joint injuries.


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