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2014, Number 3

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Revista del Hospital Psiquiátrico de La Habana 2014; 11 (3)

Heteromorfism chromosome 9 in individuals with schizophrenia

Morales-Rodríguez E, Marcheco-Teruel B, Robaina-Jimenez Z, Barrios-Martínez A, Monzón-Benítez G, Millán DN

Language: Spanish
References: 19
Page:
PDF size: 104.41 Kb.


ABSTRACT

The finding of a heteromorfism or chromosomic variant during the cytogenetic study constitute a problem to diagnose and the process of genetic expert advice due to difficulties that can exist to differentiate between a pathogenic alteration and a structural variation without adverse effects in the patients' phenotype. There various authors that associate the heteromorfic variants present in the chromosome 9 with infertility, spontaneous miscarriage and mental disorders specifically the schizophrenia and affective bypolar disorder. The schizophrenia is a mental disorder that affects the world population with a prevalence of 1% and 80% of inheritance.
Objective: To identify heteromorfisms in chromosome 9 with a possible association to schizophrenia in individuals of the Cuban population.
Methods: A transversal and descriptive study was carried out. The sample had 263 individuals with schizophrenia. Lymphocytes culture technique was used in high resolution to obtain useful metaphases for the study.
Results: Twenty individuals with heteromorfism of chromosome 9 were identify, 13 pericentric inversions of the heterochromatic zone inv (9) (p11q13). Seven with an increase in the heterochromatic region (9qh+).
Conclusions: The higher frequency of pericentric inversion ((p11q13) in this population and the increase of the heterochromatic region of the chromosome 9 shows its implication as a possible locus of sensitivity for schizophrenia that could be located in one of the implicated rupture points.


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