medigraphic.com
SPANISH

Gaceta Médica de México

ISSN 0016-3813 (Print)
  • Contents
  • View Archive
  • Information
    • General Information        
    • Directory
  • Publish
    • Instructions for authors        
  • medigraphic.com
    • Home
    • Journals index            
    • Register / Login
  • Mi perfil

2014, Number s1

<< Back Next >>

Gac Med Mex 2014; 150 (s1)

Polypharmacy prevalence and potentially inappropriate drug prescription in the elderly hospitalized for cardiovascular disease

Martínez-Arroyo JL, Gómez-García A, Sauceda-Martínez D
Full text How to cite this article

Language: Spanish
References: 36
Page: 29-38
PDF size: 241.40 Kb.


Key words:

Older adult, Fragility, Polypharmacy.

ABSTRACT

Introduction: Many older adults have multiple medical conditions that require medical attention, exposing them to polypharmacy and to a higher increase in prescribing potentially inappropriate medications. These situations may cause adverse drug reactions, longer hospital stays, and death. The prevalence of polypharmacy in our country is estimated at 55% and inappropriate prescribing of medications of 30%. Objective: To determine the prevalence of polypharmacy and potentially inappropriate drug prescription in older patients hospitalized for cardiovascular diseases. Material and methods: Patients older than 70 years from a tertiary level hospital admitted to cardiology and angiology were included, from the period 2013-2014. Fragility status, polypharmacy, and drug prescription based on the Beer’s criteria were established. The results were analyzed using descriptive statistics. For inferential analysis, cross tabulations with Pearson χ2 were used. Results: 446 patients where included, with female predominance of 56% (mean age 76.6 ± 5.9 years). The prevalence of fragility was 35.7%, polypharmacy 84.5%, and inappropriate prescription of drugs 48.9%. Coefficient correlation between inappropriate prescription of drugs and polypharmacy was p = 0.001. Conclusions: The prevalence of polypharmacy and inappropriate prescription of drugs was higher than reported previously, which shows the situational diagnosis in this tertiary level hospital, considering a population with high cardiovascular risk.


REFERENCES

  1. Ruiz J. La transición demográfica y el envejecimiento poblacional: futuros retos para la política de salud en México. Revista electrónica del centro de estudios en administración pública de la Facultad de Ciencias Políticas y Sociales. UNAM. 2011;(8):1-16.

  2. Gómez-Dantés O, Sesma S, Becerril V, Knaul F, Arreola H, Frenk J. [The health system of Mexico]. Salud Publica Mex. 2011;53 Suppl 2:s220-32. Gaceta Médica de México. 2014;150 Suppl 1 38

  3. Villagómez-Ornelas P. Evolución de la situación demográfica nacional a 35 años de la Ley General de Población de 1974. En: Consejo Nacional de Población. La situación demográfica de México 2009. México, D.F.: CONAPO; 2009. p. 14.

  4. Shi S, Mörike K, Klotz U. The clinical implications of ageing for rational drug therapy. Eur J Clin Pharmacol. 2008;64(2):183-99.

  5. Robles MJ. Tratado de geriatría para residentes. Madrid: International Marketing & Communication; 2006. p. 25-32.

  6. Neal S. The Biology of Aging and Frailty. Clin Geriatr Med. 2011;27(1):27-37.

  7. Espinoza S, Walston JD. Frailty in older adults: insights and interventions. Cleve Clin J Med. 2005;72(12):1105-112.

  8. Koller K, Rockwood K. Frailty in older adults: Implications for end-of-life care. Clin J Med. 2013;80(3):168-74.

  9. Abellan van Kan G, Rolland Y, Houles M, Gillette-Guyonnet S, Soto M, Vellas B. The assessment of frailty in older adults. Clin Geriatr Med. 2010;26(2):275-86.

  10. Rockwood K, Fox R, Stolee P, Robertson D, Beattie B. Frailty in elderly people: an evolving concept. CMAJ. 1994;150(4):489-95.

  11. Eckel SP, Bandeen-Roche K, Chaves P, Fried L, Louis T. Surrogate screening models for the low physical activity criterion of frailty. Aging Clin Exp Res. 2011;23(3):209-16.

  12. Gobbens RJ, Van Assen MA, Luijkx KG, Wijnen-Sponselee MT, Schols JM. The Tilburg Frailty Indicator: psychometric properties. J Am Med Dir Assoc. 2010;11(5):344-55.

  13. Fried LP, Tangen CM, Newman AB, et al. Frailty in older adults: evidence for a phenotype. J Gerontol A Biol Sci Med Sci. 2001;56(3):M146-56.

  14. Rolfson DB, Majumdar S, Tusuyuki R, Tahir A, Rockwood K. Validity and reliability of the Edmonton Frail Scale. Age Ageing. 2006;35(5):526-9.

  15. Suzele C, Schiaveto F, Pereira T, Hass V, Spadoti A, Partezani R. Adaptación cultural y validez de la edmonton frail scale – EFS en una muestra de ancianos brasileños. Rev Latino-am Enfermagem. 2009;17:119-25.

  16. Rollason V, Vogt N. Reduction of polypharmacy in the elderly: A Systematic Review of the Role of the Pharmacist. Drug Aging. 2003;20(11):817-32.

  17. Werder SF, Sheldon H. Managing polypharmacy: walking a fine line between help and harm. Current Psychiatry Online. 2011;2:1-13.

  18. Kaufman D, Kelly J, Rosenberg L, Anderson T, Mitchell A. Recent patterns of medication use in the ambulatory adult population of the United States: The Slone survey. JAMA. 2002;287(3):337-44.

  19. Ligia M, Gómez R. Frecuencia y factores asociados al empleo de polifarmacia en pacientes hospitalizados en el Servicio de Urgencias. Archivos de Medicina de Urgencia de México. 2011;3:49-54.

  20. Hajjar ER, Cafiero AC, Hanlon JT. Polypharmacy in elderly patients. Am J Geriatr Pharmacother. 2007;5(4):345-51.

  21. Bjerrum L, Sogaard J, Hallas J, Kragstrup J. Polypharmacy: correlations with sex, age and drug regimen. A prescription database study. Eur J Clin Pharmacol. 1998;54(3):197-202.

  22. Hilmer SN, Gnjidic D. The effects of polypharmacy in older adults. Clin Pharmacol Ther. 2009;85(1):86-8.

  23. Dimitrow M, Airaksinen MS, Kivela SL, Lyles A, Leikola SN. Comparison of prescribing criteria to evaluate the appropriateness of drugs treatment in individuals aged 65 and older: a systemic review. J. Am geriatric Soc. 2011;59(8):15421-30.

  24. Jasso J, Tovar A, Cuadros J. Prevalencia de prescripción de medicamentos potencialmente inapropiados a la población geriátrica de un hospital privado de la Ciudad de México. Med Int Mex. 2011;27(6):527-34.

  25. Kaufman D, Kelly JP, Rosenberg L, Anderson TE, Mitchell A. Recent patterns of medication use in the ambulatory adult population of the United States: The Slone survey. JAMA. 2002;287(3):337-44.

  26. Dwyer LL, Han B, Woodwell DA, Rechtsteiner EA. Polypharmacy in nursing home residents in the United States: results of the 2004 National Nursing Home Survey. Am J Geriatr Pharmacother. 2010;8(1):63-72.

  27. Hohl CM, Dankoff J, Colacone A, Afilalo M. Polypharmacy, adverse drug-related events, and potential adverse drug interactions in elderly patients presenting to an emergency department. Ann Emerg Med. 2001;38(6):666-71.

  28. Cahir C, Fahey T, Teeling M, Teljeur C, Feely J, Bennett K. Potentially inappropriate prescribing and cost outcomes for older people: a national population study. Br J Clin Pharmacol. 2010;69(5):543-52.

  29. American Geriatrics Society 2012 Beers Criteria Update Expert Panel. American Geriatrics Society updated Beers Criteria for potentially inappropriate medication use in older adults. J Am Geriatr Soc. 2012; 60(4):616-31.

  30. Alvarado BE, Zunzunegui MV, Béland F, Bamvita JM. Life Course Social and Health Conditions Linked to Frailty in Latin American Older Men and Women. J Gerontol A Biol Sci Med Sci. 2008;63(12):1399-406.

  31. Hajjar E, Hanlon JT, Sloane RJ, et al. Unnecessary Drug Use in Frail Older People at Hospital Discharge. J Am Geriatric Soc. 2005;53(9):1518-23.

  32. Steinman MA, Landefeld CS, Rosenthal GE, Berthenthal D, Sen S, Kaboli PJ. Polypharmacy and prescribing quality in older people. J Am Geriatric Soc. 2006;54(10):1516-23.

  33. García-Zenón T, López J, Roldán I, Almeida J, Villalobos J, d´Hyver C. Fármacos inapropiados en el anciano: una propuesta de clasificación. Med Int Mex. 2005;21:188-97.

  34. Avila-Beltrán R, García-Mayo E, Gutiérrez-Robledo LM, Avila-Funes JA. Geriatric medical consultation is associated with less prescription of potentially innaproppiate medications. J Am Geriatr Soc. 2008; 56(9):1778-9.

  35. Fulton MM, Allen ER. Polypharmacy in the elderly: a literature review. J Am Acad Nurse Pract. 2005;17(4):123-32.

  36. Fialova D, Topinková E, Gambassi G, et al. Potentially inappropriate medication use among elderly home care patients in Europe. JAMA. 2005;293(11):1348-58.




2020     |     www.medigraphic.com

Mi perfil

C?MO CITAR (Vancouver)

Gac Med Mex. 2014;150