2015, Number 1
<< Back Next >>
salud publica mex 2015; 57 (1)
Study of cutaneous leishmaniasis in the State of Campeche (Yucatan Peninsula), Mexico, over a period of two years.
Hernández-Rivera MP, Hernández-Montes O, Chiñas-Pérez A, Batiza-Avelar JM, Sánchez-Tejeda G, Wong-Ramírez C, Monroy-Ostria A
Language: English
References: 31
Page: 58-65
PDF size: 301.82 Kb.
ABSTRACT
Objective. To study cutaneous leishmaniasis (CL), in the
Calakmul municipality of the Campeche State, during two
years.
Materials and methods. Individuals with skin
lesions were evaluated. Aspirates taken from the lesions were
cultured, PCR was performed to diagnose the
Leishmania species.
Results. The culture detected 42% of the samples. PCR diagnosed CL in 76% of the samples; of those 38% were
from children and 62% from adults. 89% of the patients were
infected with
L. mexicana; 14.4% with Mexican strains of
L.
mexicana; 7% with
L. braziliensis; 3.6% with
L. mexicana and
L. braziliensis. The most affected villages with CL were Dos
Lagunas Sur with 12.3%, La Mancolona with 6.5% and La Guadalupe with 2.2% of prevalence, respectively. After the
treatment with Glucantime, 96% of the patients were healed.
Conclusion. CL is an important public health concern in
Calakmul, and the parasite causing it belongs to
Leishmania
mexicana and
Leishmania braziliensis complexes.
REFERENCES
World Health Organization. Fact sheet No. 375 2014.
Reithinger R, Dujardin JC, Louzir H, Pirmez C, Alexander B, Brooker S. Cutaneous leishmaniasis. Lancet Infect Dis 2007;7:581-596. Table III response of patients with cutaneous Leishmaniasis from caLakmuL, mexico, treated with megLumine antimoniate (gLucantime) Village Children Adults Age years Dose* Age years Dose* Northern Calakmul La Mancolona 6-14 5-18 18-63 5-45 Ricardo Flores Magon 0 0 27 5 La Virgen 12-17 8-16 22-65 10-65 El Carmen 10 6 18-54 5-20 Narciso Mendoza 10-14 10 20-52 10-22 Nuevo Campanario 0 0 21-49 15-39 Central Calakmul La Lucha 0 0 47 10 Ricardo Payro 13 10 28-50 37-67 Castilla Brito 0 0 29-31 25-50 La Guadalupe 12-16 3-10 40 25 Cristobal Colon 0 0 34 5 Niños Heroes 0 0 34 5 Las Tres Huastecas 0 0 26-28 5-10 Southern Calakmul Sacrificio 0 0 30 20 Dos Naciones 10-14 10-20 22-30 30 Dos Lagunas Sur 8-16 2-20 21-64 2-30 1Glucantime: one dose= 25 mg/day salud pública de méxico / vol. 57, no. 1, ener 65 o-febrero de 2015 Cutaneous leishmaniasis, Campeche, Mexico Artículo originAl
Lainson R, Shaw JJ. New World Leishmaniasis. In: Cox FEG, Wakelin D, Gillespie SH, Despommier DD, eds. Topley & Wilson’s Microbiology and Microbial Infections, 10th ed. London: Wiley & Blackwell, 2005:313-349.
Convit J, Ulrich M, Fernandez CT, Tapia FJ, Cáceres-Dittmar G, Castés M, Rondón AJ. The clinical and immunological spectrum of American cutane- ous leishmaniasis. Trans R Soc Trop Med Hyg 1993;87:444-448.
Hernandez MO, Monroy OA, McCann S, Barker DC. Identification of Mexican Leishmania species by analysis of PCR amplified DNA. Acta Trop 1998;71:139-153.
Ashford RW. The leishmanaisis as emerging and reemerging zoonosis. Int J Parasitol 2000;30:1269-1281.
Seidelin H. Leishmaniasis and babesiasis in Yucatán. Ann Trop Med Parasit 1912;6:295-299.
Andrade-Narvaez F, Simmonds DE, Rico A S. Incidence of localized cutaneous leishmaniasis (chiclero’s ulcer) in Mexico. T Roy Soc Trop Med H 1990;84:219-220.
Beltran E, Bustamante M. Datos epidemiológicos acerca de la úlcera de los chicleros (leishmaniasis americana) en México. Rev Inst Salub Enferm Ttrop 1942;3:1-28.
Canto-Lara SB, Cardenas-Maruffo M F, Vargas-Gonzalez A, Andrade- Narvaez F. Isoenzyme characterization of Leishmania isolated from human cases with localized cutaneous leishmaniasis from the State of Campeche, Yucatan Peninsula, Mexico. Am J Trop Med Hyg 1998;4:444- 447.
Kumar R, Bumb RA, Ansari NA, Mehta Rd, Salotra P et al. Cutaneous Leismaniasis caused by Leishmania tropica in Bikaner, India: Parasite identi- fication and characterization using molecular and immunologic tools. Am J Trop Med Hyg 2007;76:896-901.
El-Beshbishy HA, Al-Ali KH, El-Badry AA. Molecular characterization of cutaneous leishmaniasis in Al-Madinah Al-Munawarah province, Western Saudi Arabia. Int J Infectious Diseases 2013;17:334-338.
Reithinger R, Dujardin JC. Molecular diagnosis of leishmaniasis: current status and future applications. J Clin Microbiol 2007;45:21-25.
Espinosa-Organista D, Morrone J, Aguilar-Zu´n˜iga C, Llorente- Bousquets J. Regionalizacio´n biogeogra´fica de Me´xico: Provincias bio´ticas. In: Llorente-Bosquets JE, Gonza´lez-Soriano E, Papavero N, ed. Biodiversidad, taxonomía y biogeografía de artro´podos de Me´xico: hacia una síntesis de su conocimiento. Mexico: Universidad Nacional Auto´noma de Me´xico, 2000:61-101.
García E. Diversidad clima´tico vegetal en Me´xico. Biodiversidad, taxonomía y biogeografía de artro´podos de Mexico: hacia una síntesis de su conocimiento. En: Llorente-Bousquets J, García-Aldrete N, Gonza´lez- Soriano E, ed. México: Instituto de Biología (UNAM)/ Comisio´n Nacional para el Conocimiento y Uso de la Biodiversidad, 1996:15-25.
Flores JS, Espejel-Carvajal I. Tipos de vegetacio´n de la Península de Yucata´n. Etnoflora yucatanense. Mérida, Yucatán: Universidad Auto´noma de Yucata´n, 1994.
Smyth AJ, Ghosh A, Hassan MQ, Basu D, De Bruijn MHL, Adhya S, et al. Rapid and sensitive detection of Leishmania kinetoplast DNA from spleen and blood samples of Kala-azar patients. Parasitology 1992;105:183-192.
Hernandez MO. Diseño de herramientas moleculares para el estudio de la heterogeneidad genética de aislados de Leishmania mexicana (thesis). Mexico: Escuela Nacional de Ciencias Biológicas, Instituto Politecnico Nacional, 2000.
De Bruijn MHL, Barker DC. Diagnosis of New World leishmaniasis: specific detection of species of the Leishmania braziliensis complex by amplification of kinetoplast DNA. Acta Trop 1992;52:45-58.
Vargas-Gonzalez A, Canto-Lara SB, Damian-Centeno AG, Andrade- Narvaez FJ. Response of cutaneous leishmaniasis (Chiclero’s Ulcer) to treatment with meglumine antimoniate in Southeast Mexico. Am J Trop Med Hyg 1999;61:960-963.
Shaw J. The leishmaniasis survival and expansion in a changing world. Mem I Oswaldo Cruz 2007;102:541-547.
Andrade-Narváez FJ, Vargas-González A, Canto-Lara SB, Damián-Cen- teno AG. Clinical Picture of Cutaneous Leishmaniases Due to Leishmania (Leishmania) mexicana in the Yucatan Peninsula, Mexico. Mem I Oswaldo Cruz 2001;96:163-167.
Biagi FF, Marroquin F, Gonzalez A. Distribución geográfica de la leishmaniasis cutánea en México. Medicina 1938;38:444-446.
Zavala-Velazquez J. Leishmaniasis in Yucatán. Gac Med Mex 1972;104:1- 9, 21-25.
Lainson R. The American leishmaniasis: some observations on their ecology and epidemiology. T Roy Soc Trop Med H 1983;77:569-596.
Sanchez-Tejeda G, Rodriguez N, Parra CL, Hernández MO, Barker DC, Monroy OA. Cutaneous Leishmaniasis caused by Members of Leishmania braziliensis Complex in Nayarit, State of Mexico. Mem I Oswaldo Cruz 2001;96:15-19.
Alexander B, Agudelo LA, Navarro JF. Relationship between coffee cultivation in Colombia and exposure to Leishmania. T Roy Soc Trop Med H 2009;103:1263-1268.
Andrade-Narvaez F, Valerio-Castro E, Simmonds DE. Leishmaniasis cutánea mexicana: Índice alérgico en una población militar ubicada en una zona endémica. Rev Sanid Milit Mex 1985;39:52-154.
Canto-Lara SB, Van Wynsberghe NR, Vargas-González A, Ojeda-Farfán FF, Andrade-Narváez FJ. Use of monoclonal antibod- ies for the identification of Leishmania spp. Isolated from humans and wild rodents in the State of Campeche, Mexico. Mem I Oswaldo Cruz 1999;94:305-309.
Pech-May A, Escobedo-Ortegon FJ, Berzunza-Cruz M, Rebollar-Tellez EA. Incrimination of four sandfly species previously unrecognized as vectors of Leishmania parasites in Mexico. Med Vet Entomol 2010;24:150-161.
Desjeux P. Leishmania and the Leishmaniasis: Worldwide increasing risk factor for leishmaniasis. Med Microbiol Immun 2001;190:77-79.