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2014, Number 4

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Rev Cubana Hematol Inmunol Hemoter 2014; 30 (4)

Pneumonitis caused by cytomegalovirus in dead aids patients

Valdés CF, Fonseca GC, Capó PV, Ponce VJ, Serrano MJ, Machín GS, Arencibia NA, Forrellat BM

Language: Spanish
References: 42
Page: 360-373
PDF size: 147.76 Kb.


ABSTRACT

Introduction: Cytomegalovirus (CMV) is considered a common opportunistic germ in individuals infected with human immunodeficiency virus (HIV) often causing disease in different organs. Objective: To determine the incidence of this condition in our environment.
Material and Methods: A descriptive, ambispective study that included 105 of the 674 autopsies of AIDS patients died at the Institute of Tropical Medicine "Pedro Kouri, with postmortem diagnosis of CMV disease, between 1986 and 2008. Sociodemographic variables, main organs affected, clinical and pathological correlation, clinical and laboratory findings, relation between CD4 + T cells count and clinical forms of the disease are described.
Results: Males predominated in a ratio 4:1 as well as white skin color (80.2%). 66.6% of patients had disseminated disease. Adrenal glands (41.9%), gastrointestinal tract (30.5%) and brain (17.1%) were the most affected organs. Fever (51.4%), diarrhea (42.9%), seizures (31.4%) and physical consumption (17.1%) were the most frequent symptoms. LDH levels › 600 mmol/L were strongly associated to CMV as cause of death (p = 0.005). Nearly 70 % of patients had less than 100 cells/µL and 37.5 % less than 50 cells/µL, although this had no significant influence in the clinical forms of presentation (p = 0.641).
Conclusions: CMV disease was mainly diagnosed postmortem, usually spread and in association with high levels of LDH and CD4 count lesser than 100 cells/µL.


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