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2014, Number 4

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Rev Cubana Hematol Inmunol Hemoter 2014; 30 (4)

Immunosenescence: effects of aging process on immune system

Saavedra HD, García VB

Language: Spanish
References: 58
Page: 332-345
PDF size: 144.03 Kb.


ABSTRACT

The aging process produces functional and developmental changes in the immune system. Those changes may appear from lymphopoiesis up to the final response of the immune system facing a certain disease. Both branches of immunity, innate and adaptive, are affected by the aging process; hence these changes can have a negative impact on the immune response of elderly patients and increase their susceptibility to infectious diseases, cancer and decreased vaccine efficacy.


REFERENCES

  1. Pawelec G,Akbar A,Beverley P,Caruso C,Derhovanessian E, Fülöp T, et al: Immunosenescence and Cytomegalovirus: where do we stand after a decade? Immun Ageing 2010;7:13-20.

  2. Larbi A, Franceschi C, Mazzatti D, Solana R, Wikby A, Pawelec G. Aging of the immune system as a prognostic factor for human longevity . Physiology 2008;23:64-74.

  3. Caruso C, Buffa S, Candore G, Colonna-Romano G, Dunn-Walters D, Pawelec G et al. Mechanisms of immunosenescence. Immun Ageing 2009;6: 6-10.

  4. Yan J, Greer J, Hull R, O’Sullivan, Henderson D, Read S et al. The effect of ageing on human lymphocyte subsets: comparison of males and females. Immun Ageing 2010;7:4.

  5. Gruver AL, Hudson LL, Sempowski GD. Immunosenescence of ageing. J Pathol 2007;211:144-56.

  6. Cuba. Perfil de País: Indicadores de Desarrollo Humano. [visitado: 15 de octubre de 2013]. URL disponible en: http://hdrstats.undp.org/es/paises/perfiles/CUB.html

  7. Anuario estadístico de Cuba 2011. Edición 2012. [visitado: 15 de octubre de 2013]. URL disponible en: http://www.one.cu/aec2011/esp/19_tabla_cuadro.htm

  8. Appay V, Sauce D, Preloghe M. The role of the thymus in immunosenescence: lessons from the study of thymectomized individuals. Aging (Albany NY). 2010 Mar 20;2(2):78-81.

  9. Gui J,Mustachio LM,Su DM, Craig RW. Thymus Size and Age-related Thymic Involution: Early Programming, Sexual Dimorphism, Progenitors and Stroma. Aging Dis. 2012; 3(3): 280–90.

  10. García B, Lage A. Inmunosenescencia: implicaciones para la inmunoterapia de cáncer en los adultos mayores. Biotecnología Aplicada. 2006;23:186-93.

  11. Bains I, Yates AJ, Callard RE. Heterogeneity in Thymic Emigrants: Implications for Thymectomy and Immunosenescence. PLoS One. 2013; 8(2): e49554.

  12. Yu S, Abel L, Globerson A. Thymocyte progenitors and T cell development in aging. Mech Ageing Dev. 1997; 94:103-11.

  13. Sauce D, Appay V. Altered thymic activity in early life: how does it affect the immune system in young adults? Curr Opin Immunol. 2011; 23(4):543-8.

  14. Andrew D, Aspinall R. IL-7 and not stem cell factor reverses both the increase in apoptosis and the decline in thymopoiesis seen in aged mice. J Immunol. 2001;166:1524-30.

  15. Motta M, Ferlito L, Malaguarnera L, Vinci E, Bosco S, Maugeri D et al. Alterations of the lymphocytic set-up in elderly patients with cancer. Arch Gerontol Geriatr. 2003;36:7-14.

  16. Grubeck-Lobeinstein B, Wick G. The aging of the immune system. Adv Immunol. 2002;80:243-84.

  17. Nikolich-Zugich J. Aging and life-long maintenance of T-cell subsets in the face of latent persistent infections. Nat Rev Immunol. 2008; 8:512–22.

  18. Libri V, Azevedo RI, Jackson SE, Di Mitri D, Lachmann R, Akbar AN et al. Cytomegalovirus infection induces the accumulation of short-lived, multifunctional CD4+ CD45RA+ CD27- T cells: the potential involvement of interleukin-7 in this process. Immunology. 2011;132 :326–39.

  19. Derhovanessian E, Larbi A, Pawelec G. Biomarkers of human immunosenescence: impact of cytomegalovirus infection. Curr Opin Immunol. 2009; 21:440–5.

  20. Malaguarnera L, Cristaldi E, Malaguarnera M. The role of immunity in elderly cancer. Crit Rev Oncol Hematol . 2010;74(1):40-60.

  21. Larbi A, Pawelec G, Wong SC, Goldeck D, Tai JJ, Fulop T. Impact of age on T cell signaling: A general defect or specific alterations? Aging Res Rev. 2011;10(3):370-378.

  22. van de Berg PJ,Griffiths SJ,Yong SL,Macaulay R,Bemelman FJ,Jackson S, Akbar AN et al. Cytomegalovirus infection reduces telomere length of the circulating T cell pool. J Immunol. 2010; 184:3417–23.

  23. Pita-Lopez ML, Gayoso I, Delarosa O, Casado JG, Alonso C, Munoz-Gomariz E et al. Effect of ageing on CMV-specific CD8 T cells from CMV seropositive healthy donors. Immun Aging. 2009;6:11.

  24. Chidrawar S, Khan N, Wei W, McLarnon A, Smith N, Nayak L et al. Cytomegalovirus-seropositivity has a profound influence on the magnitude of major lymphoid subsets within healthy individuals. Clin Exp Immunol. 2009;155:423–32.

  25. Appay V, van Lier RA, Sallusto F, Roederer M. Phenotype and function of human T lymphocyte subsets: consensus and issues. Cytometry. 2008; 73:975–83.

  26. Plunkett FJ,Franzese O,Finney HM,Fletcher JM,Belaramani L, Akbar AN et al. The loss of telomerase activity in highly differentiated CD8+CD28–CD27– T cells is associated with decreased Akt (Ser473) phosphorylation. J Immunol. 2007;178:7710–9.

  27. Akbar AN, Soares MV, Plunkett FJ, Salmon M. Differential regulation of CD8+ T cell senescence in mice and men. Mech Aging Dev. 2000;121:69-76.

  28. Effros RB. Replicative senescence of CD8T cells: effect on human ageing. Exp Gerontol. 2004;39:517-24.

  29. Campisi J. From cells to organisms: can we learn about ageing from cells in culture? Exp Gerontol. 2001;36:607-18.

  30. Baarle Van D, Tsegaye A, Miedema F, Akbar A. Significance for virus-specific memory T cells responses: rapid ageing during chronic stimulation of he immune system. Immunol Let. 2005;97:19-29.

  31. Franceschi C, Monti D, Sansoni P, Cossarizza A. The immunology of exceptional individuals: the lesson of centenarians. Immunol Today. 1995;16:12-6.

  32. Buffa S, Bulati M, Pellicano M, Dunn-Walters DK, Caruso C, Colonna-Romano G et al. B cell immunosenescence: different features of naïve and memory B cells in elderly. Biogerontology. 2011;12:473–83.

  33. Frasca D, Blomberg BB. Aging affects human B cell responses. J Clin Immunol. 2011;10-9501-7.

  34. Cancro MP, Hao Y, Scholz JL, Riley RL, Frasca D, Dunn-Walters DK et al. B cells and ageing: molecules and mechanisms. Trends Immunol. 2009;30:313–18.

  35. Frasca D, Diaz A, Romero M, Landin AM, Phillips M, Lechner SC et al. Intrinsic defects in B cell response to seasonal influenza vaccination in elderly humans. Vaccine. 2010;28(51):8077–84.

  36. Bulati M, Buffa S, Candore G, Caruso C, Dunn-Walters DK, Colonna Romano G et al. B cells and immunosenescence: a focus on IgG+IgD-CD27-(DN) B cells in aged humans. Aging Res Rev. 2011;10(2):274–84.

  37. Colonna-Romano G, Bulati M, Aquino A, Pellicano M, Vitello S, Caruso C et al. A double-negative (IgD-CD27-) B cell population is increased in the peripheral blood of elderly people. Mech Aging Develop. 2009;130:81–90.

  38. Colonna-Romano G, Bulati M, Aquino A, Candore G, Malaguarnera M, Caruso C et al. B cells in the aged: CD27, CD5, and CD40 expression. Mech Aging Develop. 2003;124:389-93.

  39. Ongrádi J, Kövesdi V. Factors that may impact on immunosenescence: an appraisal. Immun Aging. 2010;7:7-21.

  40. Jing Y, Shaheen E, Drake RR, Chen N, Gravenstein S, Deng Y. Aging is associated with a numerical and functional decline in plasmacytoid dendritic cells, whereas myeloid dendritic cells are relatively unaltered in human peripheral blood. Hum Immunol. 2009;70:777–84.

  41. Agrawal A, Gupta S. Impact of aging on dendritic cell functions in humans. Aging Res Rev. 2011;10(3):336–45.

  42. Fulop T, Larbi A,Kotb R, de Angelis F, Pawelec G. Aging, Immunity, and Cancer . Discov Med. 2011;11(61):537-50.

  43. Ferguson FG, Wikby A, Maxson P, Olsson J, Johansson B. Immune parameters in a longitudinal study of a very old population of Swedish people: a comparison between survivors and nonsurvivors. J Gerontol. 1995;6:378–82.

  44. Wikby A, Maxson P, Olsson J, Johansson B, Ferguson FG. Changes in CD8 and CD4 lymphocyte subsets, T cell proliferation responses and non-survival in the very old: the Swedish longitudinal OCTO-immune study. Mech Aging Dev. 1998;102:187–98.

  45. Nilsson BO, Ernerudh J, Johansson B, Evrin PE, S, Ferguson FG, Wikby A et al. Morbidity does not influence the T-cell immune risk phenotype in the elderly: findings in the Swedish NONA Immune Study using sample selection protocols. Mech Aging Dev. 2003;124:469–76.

  46. Pawelec G, Derhovanessian E. Role of CMV in immune senescence. Virus Res. 2011;157:175–79.

  47. Pawelec G. Hallmarks of human “immunosenescence”: adaptation or dysregulation? Immun Aging. 2012;9:15.

  48. Litjens NH, de Wit EA, Betjes MG. Differential effects of age, cytomegalovirusseropositivity and end-stage renal disease (ESRD) on circulating T lymphocyte subsets. Immun Aging. 2011;8(1):2.

  49. Morgan MD, Pachnio A, Begum J, Roberts D, Rasmussen N, Neil DA, et al. CD4+CD28- T cell expansion in granulomatosis with polyangiitis (Wegener’s) is driven by latent cytomegalovirus infection and is associated with an increased risk of infection and mortality. Arthritis Rheum. 2011; 63:2127-37.

  50. Pawelec G, McElhaney JE, Aiello AE, Derhovanessian E. The impact of CMV infection on survival in older humans. Curr Opin Immunol. 2012;24(4):507-11.

  51. Solana R, Aiello AE, Akbar AN, Grubeck-Loebenstein B, Appay V, Pawelec G et al. CMV and Immunosenescence: from basics to clinics. Immun Aging. 2012; 9(1):23.

  52. Herndler-Brandstetter D, Landgraf K, Tzankov A, Jenewein B, Brunauer R, Laschober GT et al. The impact of aging on memory T cell phenotype and function in the human bone marrow. J Leukoc Biol. 2012;91:197–205.

  53. Wolf J, Weinberger B, Grubeck-Loebenstein B. The immunoregulatory effects of CMV-infection in human fibroblasts and the impact on cellular senescence. Immun Aging. 2012; 9:1.

  54. Lachmann R, Bajwa M, Vita S, Smith H, Cheek E, Akbar A et al. Polyfunctional T cells accumulate in large human cytomegalovirus-specific T cell responses. J Virol. 2012; 86:1001-09.

  55. Grubeck-Loebenstein B, Della Bella S, Iorio AM, Michel JP, Pawelec G, Solana R. Immunosenescence and vaccine failure in elderly. Aging Clin Exp Res. 2009;21:201–9.

  56. Lang PO, Govind S, Mitchell WA, et al. Influenza vaccine effectiveness in aged individuals: the role played by cell-mediated immunity. Eur Geriatr Med. 2010;1:233–8.

  57. Shammas MS. Telomeres, lifestyle, cancer, and aging. Curr Opin Clin Nutr Metab Care. 2011;14:28-34.

  58. Ames BN. Prevention of mutation, cancer, and other age-associated diseases by optimizing micronutrient intake. J Nucleic Acids. 2010:pii:72507.




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