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2014, Number 6

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Rev Med Inst Mex Seguro Soc 2014; 52 (6)

Phenotypes of bone and adipose tissue metabolism. A systematic review of their relationship

Nava-González EJ, Gallegos-Cabriales EC, Bastarrachea RA

Language: Spanish
References: 26
Page: 644-650
PDF size: 62.91 Kb.


ABSTRACT

Background: There is a central regulation of bone remodeling in the hypothalamus, a pathway that appears regulate the adipose tissue metabolism as well. The aim of the present review was to explore the evidence in literature on the relationships between bone mineral density and body composition phenotypes, leptin, adipose tissue and the insulinglucose axis.
Methods: A systematic search was conducted in electronic databases, in order to review publications addressing discussions on the link between bone mineral metabolism and adipose tissue integrative biology, published between January 2005 and November 2011.
Results: Two hundred and sixty-two articles were reviewed, out of which 12 met strict inclusion criteria (methodological design, study population and information quality control). The results suggest that cardiovascular risk phenotypes of metabolic origin and body fat are correlated with bone turnover markers and bone mineral density. Osteoporosis and obesity are two pathologies classifi ed as body composition alterations.
Conclusions: The literature review demonstrates that the fat-bone relationship involves common epidemiological, genetic and molecular aspects. These findings reflect the advances in the study of bone metabolism and adipose tissue.


REFERENCES

  1. Rosen CJ, Klibanski A. Bone, fat, and body composition: Evolving concepts in the pathogenesis of osteoporosis. Am J Med. 2009;122(5):409-14.

  2. National Osteoporosis Foundation. [Sitio web]. America's bone health: The state of osteoporosis and low bone mass in our nation. Disponible en www.nof.org/advocacy/prevalence.

  3. De Lago-Acosta A, Parada-Tapia MG, Somera- Iturbide J. Prevalencia de osteoporosis en población abierta de la Ciudad de México. Ginecol Obstet Mex. 2008;76(5):261-6.

  4. World Health Organization. Assessment of fracture risk and its applications to screening for postmenopausal osteoporosis. Report of a WHO Study Group. World Health Org Tech Rep Ser. 1994;843:1-129.

  5. Flegal KM, Carroll MD, Ogden CL, Curtin LR. Prevalence and trends in obesity among US adults, 1999- 2008. JAMA. 2010;303(3):235-41.

  6. Instituto Nacional de Salud Pública. Encuesta Nacional de Salud y Nutrición 2006. México: Instituto Nacional de Salud Pública; 2007.

  7. Hedley AA, Ogden CL, Johnson CL, Carroll MD, Curtin LR, Flegal KM. Prevalence of overweight and obesity among US children, adolescents and adults, 1999-2002. JAMA. 2004;291(23):2847-50.

  8. World Health Organization. Consultation on obesity. Geneva: World Health Organization; 2000.

  9. Rosen CJ, Beamer WG, Donahue LR. Defi ning the genetics of osteoporosis: Using the mouse to understand man. Osteoporos Int. 2001;12(10):803-10.

  10. Rosen CJ. Bone remodeling, energy metabolism, and the molecular clock. Cell Metab. 2008;7(1):7-10.

  11. Rosen CJ, Bouxsein ML. Mechanisms of disease: Is osteoporosis the obesity of bone? Nat Clin Pract Rheumatol. 2006;2(1):35-43.

  12. Greco EA, Fornari R, Rossi F, Santiemma V, Prossomariti G, Annoscia C. Is obesity protective for osteoporosis? Evaluation of bone mineral density in individuals with high body mass index. Int J Clin Pract. 2010;64(6):817-20.

  13. Andreoli A, Bazzocchi A, Celi M, Lauro D, Sorge R, Tarantino U, et al. Relationship between body composition, body mass index and bone mineral density in a large population of normal, osteopenic and osteoporotic women. Radiol Med. 2011;116(7): 1115-23.

  14. Zillikens MC, Uitterlinden AG, van Leeuwen JP, Berends AL, Henneman P, van Dijk KW, et al. The role of body mass index, insulin, and adiponectin in the relation between fat distribution and bone mineral density. Calcif Tissue Int. 2010;86(2):116- 25. Texto libre en http://www.ncbi.nlm.nih.gov/pmc/ articles/PMC2809303/

  15. Boyanov M, Bakalov D, Boneva Z. Bone mineral density in men with and without the metabolic syndrome. Aging Male. 2009;12(2-3):62-5.

  16. Choi HS, Kim KJ, Kim KM, Hur NW, Rhee Y, Han DS, et al. Relationship between visceral adiposity and bone mineral density in Korean adults. Calcif Tissue Int. 2010;87(3):218-25.

  17. Kim KC, Shin DH, Lee SY, Im JA, Lee DC. Relation between obesity and bone mineral density and vertebral fractures in Korean postmenopausal women. Yonsei Med J. 2010;51(6):857-63. Texto libre en http://www.ncbi.nlm.nih.gov/pmc/articles/ PMC2995981/

  18. Sherk VD, Malone SP, Bemben MG, Knehans AW, Palmer IJ, Bemben DA. Leptin, fat mass, and bone mineral density in healthy pre- and postmenopausal women. J Clin Densitom. 2011;14(3):321-5.

  19. Tang X, Liu G, Kang J, Hou Y, Jiang F, Yuan W, et al. Obesity and risk of hip fracture in adults: A metaanalysis of prospective cohort studies. PLoS One. 2013;8(4):e55077. Texto libre en http://www.ncbi. nlm.nih.gov/pmc/articles/PMC3625172/

  20. Cao JJ. Effects of obesity on bone metabolism. J Orthop Surg Res. 201115;6:30. Texto libre en http:// www.josr-online.com/content/6/1/30

  21. Holloway WR, Collier FM, Aitken CJ, Myers DE, Hodge JM, Malakellis M, et al. Leptin inhibits osteoclast generation. J Bone Miner Res. 2002;17(2):200-9.

  22. Collins S, Kuhn CM, Petro AE, Swick AG, Chrunyk BA, Surwit RS. Role of leptin in fat regulation. Nature. 1996;380(6576):677.

  23. Shimizu H, Shimomura Y, Hayashi R, Ohtani K, Sato N, Futawatari T, et al. Serum leptin concentration is associated with total body fat mass, but not abdominal fat distribution. Int J Obes Relat Metab Disord. 1997;21(7):536-41.

  24. Shen W, Chen J, Punyanitya M, Shapses S, Heshka S, Heymsfi eld SB. MRI-measured bone marrow adipose tissue is inversely related to DXA-measured bone mineral in Caucasian women. Osteoporos Int. 2007;18(5):641-7. Texto libre en http://www.ncbi.nlm. nih.gov/pmc/articles/PMC2034514/

  25. Goulding A. Risk factors for fractures in normally active children and adolescents. Med Sport Sci. 2007;51:102-20.

  26. Dennison EM, Syddall HE, Aihie Sayer A, Martin HJ, Cooper C; Hertfordshire Cohort Study Group. Lipid profi le, obesity and bone mineral density: The Hertfordshire Cohort Study. QJM. 2007;100(5):297- 303. Texto libre en http://www.ncbi.nlm.nih.gov/pmc/ articles/PMC208069




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