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2014, Number 1

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Revista Cubana de Ortopedia y Traumatología 2014; 28 (1)

Use of radiosynoviorthesis with chromic phospate suspensión in hemophilic patients

Baganet CA, Sagarra VM, Castillo GD, Fundora ST, Lavaut SK, Padrón MY, Castillo EF, García RE, Cruz AJ, Morín ZJ

Language: Spanish
References: 37
Page: 2-13
PDF size: 153.76 Kb.


ABSTRACT

Introduction: hemophilia is defined as an X chromosome-linked congenital anomaly that mainly occurs in males whereas females just carry the disease.
Objective: to evaluate the safety and the effectiveness of radiosynoviorthesis using 32P chromic phosphate manufactured by CENTIS to treat the chronic synovitis in hemophilic patients.
Methods: the patients who presented with more than three hemarthoses in a month were included in the study. After the patients' consent, they were injected 1 mCi of the radionuclide in the affected joint. The migration of the radiopharmaceutical was then monitored 10 minutes after the procedure as well as 1, 7 and 30 days following the treatment. Hematological and cytogenetic studies were also performed before and one year after the treatment. The bleeding frequency rate, pain and the consumption of anti-hemophilic factor were determined. Ten knees from 9 patients received this therapy (hemophilia A in 88.9 % and hemophilia B in 11.1 %). The average age of patients was 36.3 years, with a range of 23 to 59 years.
Results: there was neither significant joint leakage nor hematological change. The chromosomal study yielded normal values. Before the radiosynoviothesis with 32P, the patients exhibited a bleeding frequency rate of 10.3 times a month (range 7-13, SD ± 2.2), but this rate lowered to 0.8 (P ‹ 0.0001) within the 12 months after the procedure (range 0-4, SD ± 1.23).
Conclusions: radiosynoviorthesis with chromic phosphate is a safe effective procedure to treat chronic synovitis in the hemophilic patient.


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