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2013, Number 2

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Dermatología Cosmética, Médica y Quirúrgica 2013; 11 (2)

Drug reaction with eosinophilia: DRESS Syndrome a great simulator

Osuna OJ, Toledo BME, Valencia HA, Ramírez CE, Mena CC

Language: Spanish
References: 25
Page: 142-147
PDF size: 136.38 Kb.


ABSTRACT

Drug reaction with eosinophilia and systemic symptoms (DRESS) is a rare, life-threatening syndrome of unclear pathogenesis and a high mortality rate (10-20%), often associated with the use of antibiotic, antiepileptic and antihypertensive drugs. Signs and symptoms include high, unremitting fever; morbilliform rash; eosinophilia in over 90% of patients; and multi-organ involvement, especially the liver. Diagnosis is based on clinical features and laboratory findings, and treatment consists of removal of the causative agent, along with systemic corticosteroids and association of intravenous immunoglobulin for specific cases. This is a review of current insights and therapeutic guidelines.


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