medigraphic.com
ISSN 0210-5187 (Electronic)

2005, Number 6

<< Back Next >>

Med Cutan Iber Lat Am 2005; 33 (6)

Necrobiotic xanthogranuloma associated of unusual presentation with lymphoma

Rojas BEA, García SM, Cabrera H

Language: Spanish
References: 15
Page: 257-260
PDF size: 342.74 Kb.


ABSTRACT

Necrobiotic xanthogranuloma is an unusual clinical and pathologic condition. It may be associated with hematologic disease like monoclonal gammapathy and lymphoproliferative disorders. The cutaneous manifestations are multiple indurated nodules and red yellow plaques that eventualy ulcerate with a predilection for the periorbital area. The ocular complications are conjuntivitis, keratitis, uveitis, iritis and blindness. The histological findings reveal inflamatory granulomata with histiocytes, giant cell Touton type, bizarre foreing body type giant cells, scattered lymphocytes, eosinophils and neutrophils sorrounding necrobiotic areas. Colesterol clefts could be found. We describe a patient with unusual clinical presentation on the lumbosacral area, monoclonal Ig G gammapathy, associated to low grade lymphoma.


REFERENCES

  1. Kossard S., Winkelmann R K:Necrobiotic Xanthogranuloma with paraproteinemia. J Am Acad Dermatol 1980;3:257-70.

  2. Finan M. C., Winkelmann R K . Necrobiotic Xanthogranuloma with paraproteinemia: a review of 22 cases. Medicine 1984;65: 376 -88.

  3. Finan M. C., WinkelmannR. K. Histopathology of necrobiotic xanthogranuloma with paraproteinemia. J. Cutan. Pathol, 1987;14: 92.

  4. Fortson J. S., Schroeter A. L. Necrobiotic Xanthoganuloma with IgA paraproteinemia and extracutaneous involvement. Am J Dermatopathol 1990;12;6:579-84.

  5. Umbert I, Winkelmann R, K., Necrobiotic Xanthogranuloma with cardiac involvement. Br J Dermatol 1995;133:438.

  6. Shah K., Poonoosse S., Gerge R. Necrobiotic xanthogranuloma with cutaneous and cerebral manifestations. Case report and review of the literature. J Nerurosurg 2004;6:1111-4.

  7. Stork J., Kodetová D. Necrobiotic Xanthogranuloma presenting as a solitary tumor. Am J Dermatopathol 2000;5:453 -6.

  8. Holden C. A., Winkelmann R. K. Wilson J. Necrobiotic Xanthogranuloma:a report of four cases. Br J Dermatol 1986,114:241-50.

  9. Mehregan D., Winkelmann R. Necrobiotic Xanthogranuloma. Arch Dermatol 1992;1: 94-100.

  10. Mc Gregor J:, Miller J. Necrobiotic Xanthogranuloma without periorbital lesions. J Am Acad Dermatol 1993;3:466 -9.

  11. Burdick A., Sanchez J., Elgart G. Necrobiotic Xanthogranuloma associated with a benign monoclonal gammapathy. Cutis 2003;1:47-50.

  12. Plotnick H., Taniguchi Y. Periorbital necro bioticxanthogranuloma and stage I multiple myeloma. J Am Acad Dermatol 1991;25:373-7.

  13. Kossard S., Chow E. Lipid and giant cell poor necrobiotic xanthogranuloma. J Cutan Pathol 2000;27:374-8.

  14. Winkelmann R., Dahl P. Asteroid bodies and other cytoplasmic inclusions in necrobiotic nathogranuloma with paraproteinemia. J Am Acad Dermatol 1998;38:967-70.

  15. 15, Tang W., Lee K., Chong L. Three patients with orbital and non progressive haematological abnormalities. Australas J Dermatol 2003;3:185-9.




2020     |     www.medigraphic.com