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ISSN 0210-5187 (Electronic)

2005, Number 6

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Med Cutan Iber Lat Am 2005; 33 (6)

Behavior of ethiologic agents of onychomycosis in a mycology reference laboratory (Medellín 1994-2003)

Zuluaga DA, de Bedout C, Tabares A, Cano LE, Restrepo A, Arango M, Manrique R.

Language: Spanish
References: 17
Page: 251-256
PDF size: 272.85 Kb.


ABSTRACT

Introduction. Fungal nail lesions represent 50% of all nail disorders with variable incidence rates. Onychomycoses are caused by dermatophytic molds, yeasts of the genus Candida and environmental molds, formerly considered saprophytes. Material and Methods. We determined retrospectively the frequency and behavior of this disorder in a 10 year period (January 1.994 - December 2.003) based in the records of patients attending the Mycology Laboratory of the Corporación for Investigaciones Biológicas (CB), in Medellín, Colombia, in whom fungal lesions were suspected. Results. From a total of 23.064 mycological studies carried out, 7.024 (30,4%) specimens corresponded to nail lesions, 983 (14%) to the hand nails, 5.369 (76,4%) to foot nails and 672 (9,6%) to both localizations. In the latter, the causative agents were in their order of frequency T. rubrum (17,5%), C. parapsilosis (16,7%), Fusarium spp (13,8%), T. mentagrophytes (11,5%) and Scytalydium dimidiatum (Natrassia spp) (10,1%). C. parapsilosis and Fusarium species significantly increased with time (p‹0,01). In hand nails different species of Candida were the main etiologic agents with predominance of C. albicans (23,4%), followed by C. parapsilosis (20,8%), C. tropicalis (7,5), C. guilliermondii (4,8%) and other nonspecified Candida (12,4%). Marked diminution of T. rubrum (p‹0,025) was observed during the study period. Comments. These data confirm the high frequency of ungueal innolvement in our city and indicate that the origin of the nail disorder is predominantly suspected by the dermatologist. Additionally, the trend of changes occurring in the etiologic agents during the study period is analyzed.


REFERENCES

  1. Ghannoum MA, Hajjeh RA, Scher R, et al. A large-scale north american study of fungal isolates from nails: the frecuency of onychomycosis, fungal distribution, and antifungal susceptibility patterns. J Am Acad Dermatol 2000;43:641-8.

  2. Gill D Marks RA review of the epidemiology of tinea unguium in the comunity. Austral J Dermatol 1999;40:6 -13.

  3. Rinaldi MG. Dermatophytosis: epidemiological and microbiological update. J Am Acad Dermatol 2000;43:120 -4.

  4. Midgley G, Moore MK, Cook JC, et al. Mycology of nail disorders. J Am Acad Dermatol 1994;31:68-74.

  5. Zuluaga A, Tabares A M, Arango M, et al. Importancia creciente de los géneros Fusarium y Scytalidium como agentes de onicomicosis. Rev Asoc Col Dermat 2001;9: 593-9.

  6. Escobar ML. Carmona-Fonseca J. Onicomicosis por hongos ambientales no dermatofíticos. Rev Iberoam Micol. 2003;20:6 -10.

  7. Elewski BE. Onychomycosis: patogénesis, diagnosis and management. Clin Microbiol Rev 1997;11:415-29.

  8. Haneke E Roseeuw D. The scope of onychomycosis: epidemiology and clinical features. I J Dermatol 1999;38(Suppl.2): 7-12.

  9. Gupta AK, Jain HC, Lynde CW et al. Prevalence and epidemiology of onychomycosis in visiting physicians’ offices: A multicenter Canadian survey of 15,000 patients. J AM Acad Dermatol 2000;43: 244-8.

  10. Jain S and Sehgal VN. Onychomycosis: an epidemio-etiologic perspective. Int J Dermatol 2000;39:100 -3.

  11. Faergemann J and Baran R. Epidemiology, clinical presentation and diagnosis of onychomycosis. Br J Dermatol 2003;149(Suppl 65):1-4.

  12. Alvarez MI, González LA Castro LA. Onychomycosis in Cali, Colombia. Mycopathologia 2004;158:181- 6.

  13. Gupta AK, Ryder Je and Summerbell RC. The diagnosis of nondermatophyte mold onycchomycosis. Int J Dermatol 2003;42:272-3.

  14. Williams HC. The epidemiology of onychomycosis in Britain. Br J Dermat 1993;129:101-9

  15. Padilla M del C and Bengoa B. Onicomicosis por mohos. Dermatología Rev Mex 2004;48: 237-41.

  16. De Bedout C, Tabares A, Restrepo A et al. Especies de Candida aisladas de lesions ungueales y su sensibilidad in vitro al fluconazol (1999-2001). Rev A Col Dermatol 2003;11:325-31.

  17. De Vroey C, Desmet P, Mukamurangwa ZQ. Li.P et al. Further studies on the in vitro antifungal activity of amorolfine. Mycoses 1996;36:41-4.




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