2013, Number 3
<< Back Next >>
Rev Cub Med Int Emerg 2013; 12 (3)
Mechanical ventilation and surfactant use in children with low birth weight
Fernández NG, Lobo CM, Ferino SY
Language: Spanish
References: 19
Page: 172-180
PDF size: 329.63 Kb.
ABSTRACT
Introduction: The first’s days of mechanical ventilation of newborn infants are extremely important.
Objective: To characterize the results of mechanical ventilation and the use of exogenous surfactant in underweight newborns.
Method: An explicative and observational study over a period of four years was conducted in underweight newborns that required mechanical ventilation in the Obstetric Hospital Comandante Manuel “Piti” Fajardo of Güines, Mayabeque, in order to correlate the results obtained in the neonatal intensive care unit with the combined use of mechanical ventilator assistance and surfactant.
Results: Of a total of 395 children born with low birth weight in the centre during that period, 103 were ventilated, which constituted the sample analyzed. The variables included were birth weight, mortality, gestational age, diagnosis, use of surfactant, age at onset of ventilation and complications, Mantel and Haenszel correlation statistic chi squared was used. The results obtained in the neonatal intensive care unit with the combined use of surfactant and mechanical ventilation was analyzed.
Conclusions: The majority of patients with a diagnosis of hyaline membrane disease were ventilated before the first 12 hours of life; the very low birth weight showed better survival and that prematurity and no-administration of surfactant was associated with higher mortality. Pulmonary hemorrhage and intraventricular complication were seen.
REFERENCES
Flores HG. Estrategias de soporte ventilatorio según la fisiopatología respiratoria. Clínica de Perinatología. Puerto Montt. Chile. 2007 [citado 25 Abr 2012];34(3):35–53. Disponible en: http://www.redalyc.vaenemex.mx
Moreno Vázquez O. Surfactante y enfermedad de la membrana hialina. Revista Cubana Pediatría. 2008;80(2):1.
Asociación española de pediatría. Recomendaciones para la asistencia respiratoria del recién nacido. Grupo Respiratorio y Surfactante de la Sociedad Española de Neonatología. Anales de la Pediatría. Barcelona. 2008;68(5):16-24.
Greenough A, Donn SD. Strategy for neonatal ventilation. Department of Pediatrics, Division of Neonatal–Perinatal Medicine. Mott Children’s Hospital, University of Michigan Health System. Clinics Perinatology. 2007;34(3):35–53.
Domínguez Dieppa F, Moreno Vázquez O, Millán Cruz G, Almanza Más M. Alteraciones de sistemas orgánicos. De la Torre Montejo E, Pelayo Gonzáles- Posada EJ, editores. Pediatría. 1a ed. La Habana: Editorial de Ciencias Médicas, 2006; Vol I. p. 430-31.
Engle WA. Committee on Fetus and Newborn. Surfactant-Replacement Therapy for Respiratory Distress in the Preterm and Term Neonate. Pediatrics 2008;121:419-43.
Thomson, M. Early continuous positive airway pressure (CPAP) with prophylactic surfactant for neonates at risk of RDS. The IFDAS multicentre randomized trial. Pediatric Research. 2008;51:379.
Sweet D, Bevilacqua G, Carnielli V, Greisen G, Plavka R, Didrik Saugstad O, et al. European consensus guidelines on the management of neonatal respiratory distress syndrome. J Perinat Med. 2008;35:175–186.
Domínguez M. Complicaciones asociadas a la ventilación en la unidad de cuidados intensivos neonatales. Villa Clara. Simposio Internacional de Terapia Intensiva Neonatal y Pediátrica. Revista Cubana Pediatría. 2008;79(10):19-23
Obladen M. History of surfactant before 1980. Biol Neonate. 2006;87:308-16.
Halliday HL. History of surfactant from 1980. Biol Neonate. 2007;87:317-322.
Mazela J, Merrit T, Gadzinowski J, Sinha S. Evolution of pulmonary surfactants for the treatment of neonatal respiratory distress syndrome and pediatric lung diseases. Acta Pediátrica. 2009;95:1036-48.
Halliday HL. Recent clinical trials of surfactant treatment for neonates. Biol Neonate. 2009; 89:323-9.
Rojas MA, for the Colombian Neonatal Research Network. Very Early Surfactant Without Mandatory Ventilation in Premature Infants Treated With Early Continuous Positive Airway Pressure: A Randomized, Controlled Trial Pediatrics. 2009;123:137-42.
Blanco D. Ventilación mecánica convencional. En: De guardia en Neonatología. 2da edición. Madrid: ERGON; 2008. p.400-5.
Farhath S. Pepsin, a Marker of Gastric Contents, Is Increased in Tracheal Aspirates From Preterm Infants Who Develop Bronchopulmonary Dysplasia. Pediatrics. 2008; 121(2):253-9.
Oue S, Hiroi M, Ogawa S, Hira S, Hasegawa M, Yamaoka S, Yasui M, Tamai H, Ogihara T. Association of gastric fluid microbes at birth with severe bronchopulmonary displasia. Arch Dis Child Fetal Neonatal. 2009;94:17–22.
William A, and the Committee on Fetus and Newborn. Surfactant-replacement therapy for respiratory distress in the preterm and term neonate. Pediatrics. 2008;121:419-32.
Darlow BA, Graham PJ. Administración de suplementos con vitamina A para prevenir la mortalidad y la morbilidad a corto y largo plazo en neonatos de muy bajo peso al nacer. (Revisión Cochrane traducida). En Biblioteca Cochrane Plus. 2008; 8:122.