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2013, Number 3

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Rev Cub Gen 2013; 7 (3)

Genetic anticipation in cuban families with acne conglobata

Rojas BR, Martínez VG, Almaguer-Mederos L

Language: Spanish
References: 17
Page: 26-30
PDF size: 425.62 Kb.


ABSTRACT

Acne conglobata is a serious acne variant having a multifactorial etiology. The identification of this disease in five families of the eastern Cuban region contributed evidences of its genetic anticipation existence; though, its frequency, intensiveness, or those factors influencing or determining it are unknown. This work was aimed at characterizing the genetic anticipation phenomenon in Cuban families having acne conglobata. A descriptive study in a 37 patients sample with acne conglobata was carried out. The disease was diagnosed based on clinical criteria. Meaningful differences were found for the starting age of the disease for patients among generations (χ2= 12,86; p=0,025). The anticipation showed a 100 % frequency and its value varied between 2 and 32 years with a mean value equal to 13,04±8,85 years. Neither the sex of the progenitor transmitter of the disease (p=0,801), nor his/her conceptional age (p=0,197), nor the sex of the offspring (p=0,20), significantly influenced on genetic anticipation. The genetic anticipation in Cuban families affected by acne conglobata was demonstrated and also that it was neither influenced by the sex of the disease-transmitter progenitor, nor by his/hers conceptional age or the offspring sex.


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