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2014, Number 2

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Rev Cubana Neurol Neurocir 2014; 4 (2)

Mortality by encephalic metastasis (La Habana, 2006–2008)

Chi RD, Forteza SM, Galán ÁY, Chon RI, Ortiz RRM, Caballero GJ

Language: Spanish
References: 29
Page: 109-116
PDF size: 325.44 Kb.


ABSTRACT

Objective: To determine the clinical characteristic of brain metastases.
Methods: It was done a retrospective longitudinal descriptive study from January 1 of 2006 at December 31 the 2008 according to demographic variables and other related with the primary cancer. All the death certificates were revising in bigger than 18 years with brain metastases in anyone of the causes of death. This information was paired with the databases of the National Registration of Cancer to look for information of the moment of the diagnosis. They were 359 cases reported, of which information was obtained in 245 clinical histories. The distributions of frequencies were analyzed to describe the qualitative variables, and average with range for quantitative variables.
Results: 945 died by brain metastases were identified. The medium age was 65 years. The most frequent localizations were lung (41 %), breast (12 %) and prostate (11.3 %). Single brain metastases occurred in 50.6 % of the sample. The applied treatments were whole brain radiotherapy (48.2 %), single steroids (38.4 %), surgery (11 %) and chemotherapy (2.4 %). The halftime among the diagnosis of them brain metastases and the death was of 5.6 months. Death cause confirmation by autopsy was done in 29.4 % of the cases.
Conclusions: The brain metastases presented from a similar way to that reported in other studies with the particularity of being presented a bigger number of these in the cases with diagnosis of head cancer and neck.


REFERENCES

  1. Barnholtz–Sloan JS, Sloan AE, Faith GD, Vigneau FD, Ping L, Sawaya RE.Incidence Proportions of Brain Metastases in Patients Diagnosed (1973 to 2001) in the Metropolitan Detroit Cancer Surveillance System. J Clin Oncol. 2006;22:2865–72.

  2. Anuario Estadístico de Salud. Ministerio de Salud Pública. Dirección Nacional de Registros Médicos y Estadísticas de Salud. La Habana: 2013.

  3. Grossman R, Mukherjee D, Chang DC, Purtell M, Lim M, Brem H, Quiñones–Hinojosa A. Predictors of inpatient death and complications among postoperative elderly patients with metastatic brain tumors. Ann Surg Oncol. 2011;18(2):521–8. doi: 10.1245/s10434–010–1299–2.

  4. Carsten N, Oddvar S, Minesh PM, Anca LG, MD; Hans G. Presentation, Patterns of Care, and Survival in Patients With Brain Metastases What Has Changed in the Last 20 Years? Cancer. 2011; 117:2505–12.

  5. Caballero García J, Felipe Morán A, Toledo Valdés C, Pérez La O P, Morales Pérez I. Consideraciones anatomopatológicas y demográficas de la metástasis intracraneal. Rev Cubana Neurol Neurocir. [Internet] 2012 [citado 3 enero 2013];2(1):23–7. Disponible en: http://www.revneuro.sld.cu/index.php/neu/article/view/36

  6. Caballero García J, de Mendoza Amat JH, Cruz García O, Montero González T, Felipe Morán A. Características de la metástasis intracraneal en 14 321 autopsias realizadas en el Hospital “Dr. Luis Díaz Soto”, La Habana (1962–2011). Rev Cubana Neurol Neurocir. [Internet] 2013 [citado 7 julio 2013];3(2):132–8. Disponible en: http://www.revneuro.sld.cu/index.php/neu/article/view/157

  7. Lacerda Gallardo A, Estenoz Esquivel JC, Borroto Pacheco B. Metástasis cerebral. Estudio clínico–quirúrgico y anatomopatológico. Rev Cubana Cir. 2000;39(2):103–7.

  8. Soffietti R, Kocher M, Abacioglu UM, Villa S, Fauchon F, Baumert BG, et al. A European Organisation for Research and Treatment of Cancer phase III trial of adjuvant whole–brain radiotherapy versus observation in patients with one to three brain metastases from solid tumors after surgical resection or radiosurgery: quality–of–life results. J Clin Oncol. 2013;31(1):65–72. doi: 10.1200/JCO.2011.41.0639.

  9. Kocher M, Soffietti R, Abacioglu U, Villà S, Fauchon F, Baumert BG, et al. Adjuvant whole–brain radiotherapy versus observation after radiosurgery or surgical resection of one to three cerebral metastases: results of the EORTC 22952–26001 study. J Clin Oncol. 2011 Jan 10;29(2):134–41. doi: 10.1200/JCO.2010.30.1655.

  10. Al–Shamy G, Sawaya R. Management of brain metastases: the indispensable role of surgery. J Neurooncol. 2009;92(3):275–82. doi: 10.1007/s11060–009–9839–y.

  11. Nieder C, Spanne O, Mehta MP, Grosu AL, Geinitz H. Presentation, Patterns of Care and Survival in Patients With Brain Metastases What Has Changed in the Last 20 Years? Cancer. 2011;117:2505–12.

  12. Serizawa T, Higuchi Y, Nagano O, Hirai T, Ono J, Saeki N, Miyakawa A. Testing different brain metastasis grading systems in stereotactic radiosurgery: Radiation Therapy Oncology Group's RPA, SIR, BSBM, GPA, and modified RPA. J Neurosurg. 2012;117:31–7.

  13. Smedby KE, Brandt L, Bäcklund ML, Blomqvist P. Brain metastases admissions in Sweden between 1987 and 2006. Br J Cancer. 2009;101(11):1919–24. doi: 10.1038/sj.bjc.6605373.

  14. Goyal S, Puri T, Julka PK, Rath GK. Brief Report of a Special Case Excellent response to letrozole in brain metastases from breast cancer. Acta Neurochir (Wien). 2008;150:613–5.

  15. Dawood S, Lei X, Litton JK, Buchholz TA, Hortobagyi GN, Gonzalez–Angulo AM. Incidence of Brain Metastases as a First Site of Recurrence among Women with Triple Receptor–Negative Breast Cancer. Cancer. 2012;118:4652–9.

  16. Lonser RR, Song DK, Klapper J, Hagan M, Auh S, Kerr B, Citrin DE, Heiss JD, Camphausen K, Rosenberg SA. Surgical management of melanoma brain metastases in patients treated with immunotherapy. Neurosurg. 2011;30(115):30–6. D. Chi Ramírez et al Rev Cubana Neurol Neurocir. 116 2014;4(2):109–16

  17. Gien LT, Kwon JS, D'Souza DP, Radwan JS, Hammond JA, Sugimoto AK, Carey MS. Brain metastases from endometrial carcinoma: a retrospective study. Gynecologic Oncology. 2004;93(2):524–8.

  18. Peters P, Bandi H, Efendy J, Perez–Smith A, Olson S. Rapid growth of cervical cancer metastasis in the brain. J Clin Neurosci. 2010;17(9):1211–2. doi: 10.1016/j.jocn.2010.01.021.

  19. Roos D. What is the randomised evidence for surgery and stereotactic radiosurgery for patients with solitary (or few) brain metastases? Int J Evid Based Health. 2011;9:61–6.

  20. Soon YY, Tham IWK, Lim KH, Koh WY, Lu JJ. Surgery or radiosurgery plus whole brain radiotherapy versus surgery or radiosurgery alone for brain metastases. Cochrane Database of Systematic Reviews 2011, Issue 11. Art. No.: CD009454. DOI: 10.1002/14651858.CD009454.

  21. Tsao MN, Lloyd N, Wong RKS, Chow E, Rakovitch E, Laperriere N. Whole brain radiotherapy for the treatment of multiple brain metastases. Cochrane Database of Systematic Reviews 2006, Issue 3. Art. No: CD003869. DOI: 10.1002/14651858.CD003869.pub2.

  22. Gzell CE, Kench JG, Stockler MR, Hruby G. Biopsy–proven brain metastases from prostate cancer: a series of four cases with review of the literature. Int Urol and Nephr. 2013;45(3):735–42.

  23. Al–Shamy G, Sawaya R. Management of brain metastases: the indispensable role of surgery. J Neurooncol. 2009;92(3):275–82. doi: 10.1007/s11060–009–9839–y.

  24. Ghods AJ, Muñoz L, Byrne R. Surgical treatment of cerebellar metastases. Surg Neurol Int. 2011;2:159.

  25. Platta CS, Khuntia D, Mehta MP, Suh JH. Current treatment strategies for brain metastasis and complications from therapeutic techniques: a review of current literature. Am J Clin Oncol. 2010;33(4):398–407. doi: 10.1097/COC.0b013e318194f744.

  26. Stewart JG, Sawrie SM, Bag A, Han X, Fiveash JB. Management of brain metastases. Curr Treat Options Neurol. 2010;12:334–46.

  27. Addeo R, Caraglia M. Combining temozolomide with other antitumor drugs and target–based agents in the treatment of brain metastases: an unending quest or chasing a chimera? Expert Opin Investig Drugs. 2011;20(7):881–95.

  28. Caffo O, Veccia A, Fellin G, Mussari S, Russo L, Tomio L, Galligioni E. Frequency of brain metastases from prostate cancer: an 18–year single–institution experience. J Neurooncol. 2013;111(2):163–7. doi: 10.1007/s11060–012–0994–1.

  29. Nieder C, Pawinski A, Balteskard L. Colorectal cancer metastatic to the brain: time trends in presentation and outcome. Oncology. 2009;76(5):369–74. doi: 10.1159/000210026.




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