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2013, Number 2

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Rev Cub Gen 2013; 7 (2)

Prenatal cytogenetic diagnosis in the Granma province: 2008-2010

Moreno MH, Gamboa VA, Cedeño AN, Cabrera GA, Meriño PG, Mendoza TY

Language: Spanish
References: 12
Page: 19-22
PDF size: 400.05 Kb.


ABSTRACT

A descriptive transversal cut of the prenatal cytogenetic diagnosis program in the Granma province during the period 2008-2010 was carried out. The information was retrieved from the registries of the Cytogenetic Laboratory in the province. The indication motive for the study, diagnosed anomalies, result type and most frequent aberration were analyzed. The most frequent indication was increased maternal age, identifying that 93 % of all chromosomal anomalies found were linked to this group. A gradual decrease in the number of resultless studies was noted, while trisomy-21 was the chromosomal aberration showing higher occurrence frequency, found in 92,5 % in increased maternal age patients. Down syndrome prevalence on birth was equal to 0,4 per 1 000 born alive, while the prevalence in the prenatal cytogenetic studies was equal to 18,4 per 1 000 patients studied, clearly highlighting the influence of the diagnostic test in decreasing born alive babies with this syndrome.


REFERENCES

  1. Marcheco Teruel B. Aspectos Legales en la práctica de la Genética Médica. Rev Cubana Gen Comunit. 2010;4(3):5-8.1.

  2. ACT Cytogenetics Laboratory Manual. 22. nd ed. Ed. Margaret J Barch., New York: Raven Press; 1991.

  3. ISCN 2005. An internacional System for Human Cytogene-Cytogenetic Nomenclatura. Shaffer LG, Tomnerup N Basel: 3. Karger, 2005.

  4. Vieira AR, Castillo TS. Edad materna y defectos del tubo neural: evidencia para un efecto mayor en espina bífida que anen4. cefalia. Rev Méd Chile. 2005;133:62-70.

  5. González Lucas Norma. Salud sexual y reproductiva y genética en Cuba. Rev Cubana Gen Comunit. 2010;4(1):3-4. 5.

  6. Héctor Ignacio Pimentel Benítez, Aniorland García Borrego, Nelson Martín Cuesta,Yanelis Alonso Barba, Milagros Torres 6. Palacios,Ursulina Suárez Mayedo.Diagnóstico Prenatal Citogenético en Camagüey. Resultados de 20 años. Rev Cubana Gen Comunit. 2008; 2(3):34-38.

  7. Sherman SL. Risk factors for nondisjunction of trisomy 21. Cytogenetic Genome Res.7. 2005;111:273-280.

  8. ECLAMC: 34 años de vigilancia epidemiológica del síndrome de Down en el Hospital Clínico de la Universidad de Chile. 8. 1972-2005. Rev Méd Chile. 2006;134:1436-44.

  9. Kazaura and col. Increasing Risk of Gastroschisis in Norway: An Age-Period-Cohort Analysis. American Journal Epide9. miol. 2004;159(4).

  10. Julio Nazer. Edad materna y malformaciones congénitas. Un registro de 35 años (1970-2005). Rev Médica Chile. 10. 2007;135:1463-1469.

  11. Barrios MA. Manual de Buenas Prácticas para el Laboratorio de Citogenética. La Habana: Centro Nacional de Genética 11. Médica; 2011.

  12. Proenza Rodríguez Reinaldo. Estrategia de educación, promoción y prevención para la percepción del riesgo genético en las 12. mujeres en edad fértil. Rev Humanidades Médicas. 2011;11(1):63-80.




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