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2013, Number 2

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RCAN 2013; 23 (2)

Gut flora and energy metabolism after bariatric surgery

Ochoa C

Language: Spanish
References: 71
Page: 309-321
PDF size: 266.62 Kb.


ABSTRACT

In a world besieged by the epidemic of obesity, bariatric surgery has emerged as an alternative for controlling the progression of this comorbidity towards the Metabolic syndrome complications such as Diabetes mellitus and arteriosclerosis. Gastric bypass followed by a Roux-in-Y jejuno-jejunostomy, has been the most effective bariatric procedure in the control of complications associated with obesity. Bariatric surgery produces changes in the anatomy, motility and functions of the digestive tract; modifies the paracrine enterohormonal pattern, and reduces the obese´s food intakes. All these changes lead to the reduction of insulin resistance, and hence, a better use of glucose by cells, tissues and organs in the periphery, return of serum glucose to normality, and diminishment of glycated Hemoglobin values. Bariatric surgery also affects bacterial composition of gut flora, and it is believed that this event might also help in a better use of glucose by the periphery. Results of experimental models in animals, combined with observations of bariatrized patients, have led many to suggest that gut flora may exert an important role in the development of Metabolic syndrome, and also, contribute with its treatment once bariatric surgery is performed.


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