Carmenates ND, Monzón BG, Lardoeyt FR, Riverón FG, Lemus MG, Martínez BO, Cásido RM, Llamos PA

Language: Spanish
References: 26
Page: 12-17
PDF size: 404.96 Kb.

ABSTRACT

Autism is a behavior disorder with a marked communication and social interaction deficit. In turn, it also constitutes one of the most complex problems from the personal, familial and social points of view that can appear in infancy. It has been suggested that oxidative stress plays a role in the physiopathology that lies behind the emergence of conducts defining autism. The present investigation was carried out with the objective of measuring oxidative damage and antioxidant defense markers in patients with autistic spectrum disorders. A total of 15 cases and 30 controls were studied, determining the oxidative damage and antioxidant defense markers to all of them. Plasmatic level values of malondialdehyde and advanced protein oxidation products turned out to be higher in the cases than in controls. The catalase mean intraerythrocytic activity level was less in the cases (p=0,000003), while no differences were found between the superoxide dismutase mean activity level values in both groups. Free thiols plasmatic concentrations were greater (p=0,020) in patients as compared with controls. Results of this study suggest the presence of oxidative stress conditions in those patients with autistic spectrum disorders. These evidences must be obtained for a greater number of cases due to their possible usefulness in therapeutic strategies.

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