2014, Number 1
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Rev Cubana Estomatol 2014; 51 (1)
Matrix metalloproteinases and their considerations in Dentistry from the field of computational chemistry
Díaz CA, Méndez CD, Martínez SE, Orozco PJ, Rosa VM
Language: Spanish
References: 35
Page: 80-92
PDF size: 255.20 Kb.
ABSTRACT
Matrix metalloproteinases are a family of zinc-dependent proteases responsible for
the remodeling the protein components of extracellular matrix of all tissues; its
catalytic activity is controlled by tissue inhibitors of matrix metalloproteinases. At
pathological conditions the balance between MMPs regarding these endogenous
inhibitors is lost, this imbalance is evident in oral diseases including dental caries,
gingivitis, periodontitis, among others, hence the possibility of achieving selective
inhibition of activity of these enzymes with synthetic inhibitors is a promising
approach in the treatment of various diseases of the oral cavity. A literature review
aimed at analyzing the role of matrix metalloproteinases in the development of oral
diseases and identify the contribution made by the computational analysis of these
enzymes in the field of dentistry is presented below. To this end a search of the
literature available was conducted in databases such as Pubmed, Sience Direct,
Ovid, and Ebsco Host using keywords like: oral pathology, oral cancer, dentin
bonding, matrix metalloproteinases, synthetic inhibitor of metalloproteinases, and
molecular modeling. 35 items were selected to guide this review. At the end it was
concluded that there is positive correlation between deregulation of certain MMPs
and progression of certain oral diseases, this has boosted in silico identifying and
designing effective inhibitors for these proteins, based on structure-activity
relationship analysis and molecular docking computational. To date it has
successfully demonstrated that the most potent inhibitors of MMPs have
hydroxamate groups. So far it has successfully demonstrated that the most potent
inhibitors of MMPs have hydroxamate groups. Considering the above, the design of
compounds that block the chemopreventive activity represents a rational strategy
for the inhibition of MMPs.
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