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2014, Number 2

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Rev Cubana Pediatr 2014; 86 (2)

Vascular and renal damage markers observed in urine from obese children and adolescents

Pérez CLM, Herrera VR, Chong LA, Villacís PD, Fernández MI

Language: Spanish
References: 28
Page: 168-178
PDF size: 267.73 Kb.


ABSTRACT

Introduction: microalbuminuria is considered to be a marker of endothelial dysfunction, vascular damage, renal damage and cardiovascular disease in addition to be an independent risk factor for morbidity and mortality. Similarly, proteinuria has been identified as an independent risk factor for chronic renal disease and a predictor of all causes of mortality. Both are relatively frequent in obese subjects.
Objective: to determine the frequency of vascular and renal markers in the urine from obese children and adolescents.
Methods: prospective, observational and analytical study of obese children and adolescents seen at the reference service called obesity and kidney in the teaching pediatric hospital of Centro Habana. The study was conducted from January 2009 through December 2012. Vascular and renal markers were determined in the urine (microalbuminuria and proteinuria). The statistical analysis was based on SPSS program version 13.0.
Results: there was just one patient detected with proteinuria (0.5 %); however, in the microalbuminuria test, it was found that over half of the patients (70.8 %) were positive to this vascular and renal damage marker. In the histopathological analysis of the renal biopsy taken from the patient with proteinuria, segmental glomerulosclerosis and adhesion to Bowman's capsule was discovered.
Conclusions: obese children and adolescents have very frequent positivity to vascular and renal damage markers, mainly microalbuminuria.


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