2014, Number 2
Hospital fatality for community-acquired pneumonia according to the initial antimicrobial treatment
Language: Spanish
References: 21
Page: 144-164
PDF size: 172.02 Kb.
ABSTRACT
Objective: to determine lethality behavior of community acquired pneumonia as initial empirical antimicrobial therapy in hospitalized patients.Methods: a prospectively descriptive observational study was performed of case series, 421 patients with coincident diagnosis of community acquired pneumonia at admission and discharge from January 2012 to June 2013. Information from clinical records was used. Chi2 statistic and exact Fisher's test were used in the statistical analysis for differences in proportions; and the odds ratio to measure the strength of association antimicrobial-lethality products accepted confidence level was 95 % (p ‹ 0.05).
Results: the lowest lethality was observed in patients treated with cefuroxime (17 %), and highest in those treated with cefotaxime (44 %) and ceftriaxone (35 %), with statistically significant differences. The differences in mortality from pneumonia among those treated with cefuroxime and those treated with amoxicillin/sulbactam or ceftriaxone increased with patient age, which was also statistically significant. In patients with severe pneumonia and unlikely to recover, extremely high lethalities were found in those treated with ceftriaxone (81 %) and cefotaxime (75 %).
Conclusions: cefuroxime was the antibiotic used initially associated with lower mortality, as opposed to the use of ceftriaxone or cefotaxime income. Amoxicillin/sulbactam, as initial empirical therapy, occupied an intermediate position.
REFERENCES
Corona Martínez LA, Fragoso Marchante MC, González Morales I, Sierra Martínez DP, Borroto Lecuna S, Chávez Troya O. Aplicación de un instrumento para la estratificación del paciente con neumonía adquirida en la comunidad en el Departamento de Urgencias. Medisur 2011 [citado Nov. 2013];9(5). Disponible en: http://www.medisur.sld.cu/index.php/medisur/article/view/1544
Corona Martínez LA, Fragoso Marchante MC, Borroto Lecuna S, Hernández Abreus C, Home López Viera B, Dominguez Casillas I. Un instrumento para la estratificación del paciente con neumonía adquirida en la comunidad en el departamento de urgencias. Rev Cubana Med. 2006. [citado Nov. 2013];45(2). Disponible en: http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S0034- 75232006000200012&lng=es&nrm=iso
Fragoso Marchante MC, Espinosa Brito AD, Álvarez Amador G, González Morales I, Bernal Muñoz JL, Mosquera Fernández MA. Adherencia a las guías de prácticas clínicas sobre neumonía adquirida en la comunidad y su relación con la mortalidad. Medisur 2010 [citado nov. 2013];8(4). Disponible en: http://www.medisur.sld.cu/index.php/medisur/article/view/880
Torres A, Barberán J, Falguera M, Menéndez R, Molina J, Olaechea P, et al. Guía multidisciplinaria para la valoración pronostica, diagnóstico y tratamiento de la neumonía adquirida en la comunidad. Med Clin (Barcelona) [citado Nov. 2013];140(5). Disponible en: http://dx.doi.org/10.1016/j.medcli.2012.09.034
Tirado Bientz JI, Cigales Reyes MJ, Morejón García M. Terapéutica antimicrobiana en la neumonía adquirida en la comunidad. Rev Haban Cienc Méd [revista en Internet]. 2013 [citado Ag. 2013];12(2):202-11. Disponible en: http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S1729- 519X2013000200007&lng=es
Bantar C, Cursio D, Jasovich A, Bagnulo H, Arango Á, Bavestrello L, et al. Neumonía aguda adquirida en la comunidad en adultos: Actualización de los lineamientos para el tratamiento antimicrobiano inicial basado en la evidencia local del Grupo de Trabajo de Sudamérica (ConsenSur II). Rev Chil Infect. 2010;27 (Supl 1):9-38.