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2014, Number 3

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Investigación en Discapacidad 2014; 3 (3)

Medical importance of biofilms of Staphylococcus epidermidis in prosthetic joint infections

Ortega-Peña S, Franco-Cendejas R

Language: Spanish
References: 71
Page: 106-113
PDF size: 277.62 Kb.


ABSTRACT

Joint replacement is a surgical procedure performed in patients with articular wear. This surgery helps them to improve their mobility and quality of life; however, it can cause complications in some cases. Prosthetic joint infection is the most serious and catastrophic complication that may occur after a joint replacement procedure. The most common etiologic agent in these infections is Staphylococcus epidermidis. Prosthetic joint infections that are caused by S. epidermidis are usually chronic and persistent because these microorganisms are found as a biofilm. This biofilm is a barrier that protects the bacterial cells from the action of antibiotics and the host’s immune response. The formation of the biofilm is a complex process that occurs in four phases. Better understanding of the pathophysiology of infections caused by biofilm-producing microorganisms can help to find more effective therapeutic strategies.


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