Góngora RA, Parra FLY

Language: Spanish
References: 0
Page: 203-211
PDF size: 265.22 Kb.

ABSTRACT

Background: The determination of the percentage of sperm DNA fragmentation has become a routine test of many laboratories due to its correlation with the diagnosis of fertility in men. Many causes have been determined for its rise, like the alteration in the processes of apoptosis and spermatogenesis. In human beings and animals, variations in the rates have been reported, until coming to an individual response; there are several consequences and they depend on the severity of the damage caused in the DNA. Objective: To determine the percentage of fragmentation with the chromatin dispersion technique in patients with a history of problems to conceive of the Human Fertility Center in Mexico. Material and methods: 268 espermatobioscopies were analyzed with sperm nuclear chromatin evaluation. Results: There were significant differences (p › 0.0001) between normozoospermic, hipospermic, oligozoospermic, oligoastenozoospermic, teratozoospermic and astenoteratozoospermic patients. The results changed according to the diagnosis, and a significant increase was demostrated when abnormalities of the parameters of the spermatobioscopy increased. Conclusion: The percentage of sperm DNA fragmentation increases with the finding of abnormalities in the spermatobioscopy; we found correlation with the increase of morphologic abnormalities and the decrease in spermatic motility.