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2011, Number 1

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Rev Cub Gen 2011; 5 (1)

Influence of the genome-environment interaction in type 2 diabetes mellitus in a municipality of Camagüey province

Quirós RY, Lardoeyt FR, Arrieta GR, Medina AFE

Language: Spanish
References: 23
Page:
PDF size: 217.89 Kb.


ABSTRACT

The origin of diabetes mellitus (DM) is the result of genetic and environmental factors and their interaction, a fact that makes it difficult to study them, due to the complexity of their etiopathogeny. The aim of this article was to determine the interaction of the genetic and environmental factors in the phenotype expression of type 2 diabetes. It was carried out through an analytic observational study of cases and controls, paired 1:2. Sixty patients were selected diagnosed with type 2 diabetes and one hundred twenty controls, born in the period between January 1950 and December 1970, of the municipality Camagüey. The Odds Ratio was calculated as a measure of the degree of association. There was a slight prevalence of the feminine sex, and the onset age of the disease varied between 40 and 50 years. The risk of suffering the disease increased for DM-associated obese patients when the patient had a first-degree relative also having DM. The maternal inheritance of the disease was the most frequent in all cases. It is concluded that the risk of getting the disease, attributable to the interaction between genome and environment, is greater than the ones due to their individual effects.


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