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2014, Number 2

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Residente 2014; 9 (2)

Células troncales del cáncer como nuevas herramientas para combatir el adenocarcinoma de páncreas

Félix-Félix AK, Sánchez-Ramírez D, Flores-Figueroa E

Language: Spanish
References: 35
Page: 59-65
PDF size: 246.83 Kb.


ABSTRACT

This review presents, from a basic perspective, the status of the knowledge of cancer stem cells in pancreatic ductal adenocarcinoma (PDAC), and the relevance of this knowledge to generate new and better therapeutic strategies. PDAC is one of the most fatal cancers, with a survival rate of 5% at 5 years. In USA is placed within the fourth leading cause of cancer death in men and women. The poor prognosis is due to a silent nature of the disease, associated with a late diagnosis, high metastatic potential and resistance to conventional chemotherapy and radiation. Cancer stem cells are those cells within the tumor, with the ability to self-renew and to produce a tumor on an animal model. In 2007, Li et al, reported for the first time, the presence of cancer stem cells in PDAC. Conventional therapies including gemcitabine, are not able to affect the population of cancer stem cells, favoring resistance and tumor recurrence. Therefore, there is a need to develop therapies against cancer stem cells.


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