Vadillo E, Pelayo R

Language: Spanish
References: 27
Page: 51-58
PDF size: 319.81 Kb.

ABSTRACT

Among the tissues with highest turnover rate, the blood is one of the most studied nowadays. It is estimated that an adult person produces about 3 x 10⁵ erythrocytes and 3 x 10⁴ leukocytes per second. However, under inflammation and stress conditions, such production rate is often modulated. In order to achieve this phenomenon, the most primitive cells of the hematopoietic system must recognize pro-inflammatory cytokines and growth factors, evolutionally conserved pathogen components and their products, as well as damage-associated endogenous molecules. All these factors, in addition to close interactions with components of the hematopoietic microenvironment, specifically modulate the production of myeloid and lymphoid lineages to generate the cells needed for elimination of noxious agents. In this review, we will focus on mechanisms by which pathogens, their products and some damage-associated molecules modulate blood cell production in both humans and mice in the context of inflammation.

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