Flores-Méndez VM, Aguilar-Roa PD

Language: Spanish
References: 33
Page: 5-13
PDF size: 196.77 Kb.

ABSTRACT

Introduction: Preeclampsia (P) has a global maternal mortality rate of 6 to 12%. The etiology is multiple; within this is the study of hormonal factors. One of the pathologies associated with P is hypothyroidism, which has been linked to severity by up to 16%. Probably the change in the operation may affect placental estrogen production necessary for good thyroid function in pregnancy, in this way increase in the maternal circulation androgenic precursors, particularly total and free testosterone. It is thought that elevated levels of TSH are associated with increasing T and fT, enhancing their vasoconstrictor effects. Objective. To determine whether increased levels of TSH are associated with increased T and fT levels in preeclamptic patients (PP), compared with a control group of healthy patients. Material and methods. We measured TSH, T and fT in plasma of 47 PP and 47 healthy patients (S). The results obtained were compared between groups. The control group was as similar as possible to the group of PP. Results. Measurements of TSH, T and fT showed statistically significant differences (p ‹ 0.05). To perform test one-way ANOVA; it was observed that the mean difference within and between group was statistically significant (p ‹ 0.05). In post hoc tests, not was observed difference between preeclamptic patients. Conclusion. If there is an association between subclinical hypothyroidism and hipertestosteronemia in preeclamptic patients. The largest association was observed in the PS, and this group had poor perinatal outcome.

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