2010, Number 1
<< Back Next >>
Rev Cub Gen 2010; 4 (1)
Family grouping for cancer in individuals with lung cancer
Reyes BK, Marcheco TB, Crombet RT
Language: Spanish
References: 23
Page: 11-18
PDF size: 320.74 Kb.
ABSTRACT
An analytical study of control cases was carried out to evaluate cancer family grouping in relatives of individuals with lung cancer. Sixty patients diagnosed with lung cancer of non-small cells in stages IIIB or IV, from the Havana City province were evaluated, the controls being their respective spouses. The larger per cent of cases were of masculine sex, with a secondary education level, non-exposed to toxic substances, eating vegetables at least once a week and were smokers before the diagnosis. They have previous family cases of cancer and they were diagnosed being 55 years old, with a subsequent evolution of 1 to 3 years. In The risk
factors for lung cancer found were nicotine poisoning, insufficient eating of vegetables, obesity and sedentary life. Relative risk and
odds ratio were computed for the family grouping study that allowed evaluating the association degree in the influenced families as well as in the uninfluenced ones. Significant influence of family grouping for cancer in any anatomical location was found.
REFERENCES
Galán Y, et al. Trends in Cuba’s Cancer Incidence (1990 to 2003) and Mortality (1990 to 2007). MEDICC Review. Summer 2009;11(3).
Anuario Estadístico de Salud en Cuba. Disponible en: http://bvs.sld.cu/anuario.
Roca Goderich R. Temas de Medicina Interna. Tomo I. 4ta ed. La Habana: Editorial Ciencias Médicas; 2002.
Cancer risk factors. Cancer Facts & Figures. EUA:American Cancer Society; 2002.
Mayne ST, Buenconsejo J, Janerich DT. Familial cancer history and lung cancer risk in United States nonsmoking men and women. Cancer Epidemiol Biomarkers Prev. 1999;8:1065–9.
Peñate MM. Medicina interna. Diagnóstico y tratamiento. La Habana: Editorial Ciencias Médicas; 2005.
Kasper DL, Braunwald E, Fauci AS. Harrinson. Principios de Medicina Interna. 16o ed.. 2006.
García B, Neninger E, de la Torre A et al. Effective Inhibition of the Epidermal Growth Factor/Epidermal Growth Factor Receptor Binding by Anti-Epidermal Growth Factor Antibodies Is Related to Better Survival in Advanced Non-Small-Cell Lung Cancer Patients Treated with the Epidermal Growth Factor Cancer Vaccine. Clin Cancer Res. 2008;14(3). Disponible en: www.aacrjournals.org
Neninger E, Osorio M, Catala M, de la Torre A, Acosta Z, Rives R, Viada C, Garcia B, Crombet T, Gonzalez G, Lage A. Phase II Randomized Controlled Trial of an Epidermal Growth Factor Vaccine in Advanced Non–Small-Cell Lung Cancer. J Clin Oncol. 2008;26:1452-1458.
Mendelsohn J, Baselga J.Status of epidermal growth factor receptor antagonists in the biology and treatment of cancer. J Clin Oncol. 2003;21(14):2787-99.
Stein CJ, Colditz GA. Modifi able risk factors for cancer. British Journal of Cancer. 2004;90:299-303.
Sridhar SS, Seymour L, Shepherd FA. Inhibitors of epidermal- growth-factor receptors: a review of clinical research with a focus on non-small-cell lung cancer. Lancet Oncol. 2003;4(7):397-406.
Gorlova OY, Feng Weng S, Zhang Y, Amos CI, Spitz MR. Aggregation of cancer among relatives of never-smoking lung cancer patients. Int J Cancer. 2007;121:111-118.
Tokuhata GK, Lilienfeld AM. Familial aggregation of lung cancer on humans. J Natl Cancer Inst. 1963;30:289-312.
Ooi WL, Elston RC, Chen VW, Baily-Wilson JE, Rothschild H: Increased familial risk for lung cancer. J Natl Cancer Inst. 1986;76:217-222.
Jin Y, Xu Y, Xu M, Xue S. Increased risk of cancer among relatives of patients with lung cancer in China. BMC Cancer. 2005;5:146.
Matakidou A, Eisen T, Houlston RS. Systematic review of the relationship between family history and lung cancer risk. Br J Cancer. 2005;93:825–33.
Yang P, Schwartz AG, McAllister AE, Aston CE, Swanson GM. Genetic analysis of families with nonsmoking lung cancer probands. Genet Epidemiol. 1997;14:181-97.
Jin YT, Xu YC, Yang RD, Xu CW, He XZ: Familial aggregation of lung cancer in a high incidence area in China. Brit J Cancer. 2005;92:1321-1325.
Sellers TA, Ooi WL, Elston RC, Chen VW: Increased familial risk for non-lung cancer among relatives of lung cancer patients. Am J Epidemiol. 1987;126:237-246.
Wu PF, Lee CH, Wang MJ, Goggins WB, Chiang TA, Huang MS, Ko YC: Cancer aggregation and complex segregation analysis of families with female non-smoking lung cancer probands in Taiwan. European Journal of Cancer. 2006;40:260-266.
Schwartz G: Genetic predisposition to lung cancer. Chest. 2006;125(5 suppl):86S-89S.
Larsen JE, Colosimo ML, Yang IA, Bowman R, Zimmerman PV, Fong KM: CYP1A1 Ile462 and MPO G-463A interact to increase risk of adenocarcinoma but not squamous cell carcinoma of the lung. Carcinogenesis. 2005; Sep 29.