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2013, Number 3

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Cuba y Salud 2013; 8 (3)

Infections by Epstein-Barr virus and cytomegalovirus in patients with mononucleosic syndrome

Correa SCB, Kourí CV, Pérez SL, Alemán CY, Soto BY, Álvarez LA, Añé KAL

Language: Spanish
References: 30
Page: 15-20
PDF size: 272.56 Kb.


ABSTRACT

Objective: To identify the frequency of infections by Epstein Barr virus (EBV) and the cytomegalovirus (CMV) as ethiologic agents of the mononucleosic syndrome in Cuba.
Method: 555 sera of patients with presumptive diagnosis of mononucleosic syndrome were studied (2006-2011) by ELISA inmunoenzymatic assays, according to the protocols described for EBV and CMV viruses, by the producers of DiaSorin commercial house (Italy). The risk, confidence interval and statistic signification amongst the different variables were determined.
Results: IgG prevalence was 80,2% and 64,3% for CMV and VEB, respectively. Active infection (primary or recurrent) by EBV (35,9%) o CMV (17,3%), was found in 53,2% of the samples, being significantly more frequent by EBV (OR:2,9, CI:2,2-3,9, p ≤ 0,0001). Similar behavior was observed for primary infections (17,8% vs 2,9%) (OR: 7,7, CI: 4,4-13,3, p ≤ 0,0001). Active infections, were less frequent among the seropositives to HIV (7,9% for CMV, 21,1% for EBV). The majority of primary infections (CMV 74,7%, EBV 93,7%) were identified in patients under 18 years, with higher risk for the infections caused by CMV (OR: 12,5, CI: 1,6-95 p=0,0010) and EBV (OR: 2,8, CI:1,7-4,5 p ≤ 0,0001), respectively.
Conclusions: It was confirmed that primary and recurrent infections by the Epstein Barr virus are frequent cause of the mononucleosic syndrome, although the cytomegalovirus can also produce it. The study results emphasize on the importance of combining serologic with molecular studies for the herpesvirus diagnosis as agents causing the mononucleosic syndrome.


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