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Academia Mexicana de Neurología, A.C.

2014, Number 4

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Rev Mex Neuroci 2014; 15 (4)

Skull base chordomas

Gutiérrez-Partida CF, Ramírez-Barrios LR, Delgado-Peña B

Language: Spanish
References: 26
Page: 207-210
PDF size: 264.19 Kb.


ABSTRACT

Chordomas are slow-growing neoplasias of the midline, representing about 1% of malignant tumorsarising from bone, and from 0.1 to 0.2% of intracranial neoplasms. Originating from embryonic notochord, they symptoms begin between the third and fifth decade of life, with an average age of 43 years. They are presented as a mass lesion in the clival region, with destruction and extension to nasopharynx. Definitive diagnosis is made by histopathological evaluation. Survival of untreated patients ranges from 28 months after onset of symptoms to 6.6 years and 3.6 years after radiation and surgery, respectively. Chemotherapy has not proved benefical, but it is usually offered to very young patients in order to reduce the tumoral mass, and to reach an older age in which radioterapy treatment is indicated. There are limitations with regard to treatment, even with current advances in imaging techniques and surgical resection.


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