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2014, Number 3

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Med Crit 2014; 28 (3)

Cerebrovascular reactivity in sepsis and septic shock at high altitude

Viruez-Soto JA, Da Re-Gutiérrez S, Ibáñez-Guzmán C

Language: Spanish
References: 8
Page: 154-158
PDF size: 195.29 Kb.


ABSTRACT

Objective: To evaluate a significant compromise in cerebrovascular reactivity in septic and septic shock patients at 3,600 meter above the sea level.
Design: Prospective longitudinal case-control study.
Field: Intensive care unit of the «Hospital Obrero Número 1 de la Caja Nacional de Salud», a tertiary university hospital, in La Paz, Bolivia during the period November 2011–February 2012.
Patients and participants: Septic patients (n = 10) and «healthy» volunteers (n = 11), all residents of 3,600 meter above the sea level during the last six months.
Results: With transcranial ecodoppler, the mean velocity of the cerebral blood flow of the middle cerebral artery with the best insonation sign was measured, before and after the administration of 1 g of acetazolamide. The velocity in the «septic group» increased 31.9% and in the «control group» 30.2% (p = 0.3770, CI 95% from 0.1559 to 0.597), without significant changes in the pulsatility index nor the mean arterial pressure.
Conclusion: This study demonstrates the lack of significant compromise of cerebrovascular reactivity in septic patients at high altitude.


REFERENCES

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