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2011, Number 4

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Rev Cub Med Int Emerg 2011; 10 (4)

Thromboelastography versus coagulation profile for the risk of thrombosis in the patient with severe sepsis

Pérez RFJM, Macías GMT, Gómez GRO

Language: Spanish
References: 27
Page: 2273-2284
PDF size: 219.58 Kb.


ABSTRACT

Introduction: The severe sepsis predisposes to spread intravascular coagulation with risk of to provoke micro-thrombosis ana multiple organ failure.
Objective: To determine the sensitivity and specificity of the thromboelastography versus coagulation profile for thrombosis in patients with severe sepsis.
Methods: A prospective, comparative, analytical and observational study was conducted from May to September, 2011 in patients presenting with severe sepsis including the study to those aged › 18 of both sexes, excluding those patients with active hemorrhage. Admission was needed and at 72 hours, the coagulation profile and a thromboelastography. For the numerical variables authors used the Mann-Whitney U-test of and for qualitative ones the X2 test was used.
Results: Fifteen patients were studied with a mean age of 46 years. An increase of fibrinogen, of the D dimer and of the C protein, a decrease of S protein and the antithrombin III was reported. The thromboelastography reported a lengthening of reaction time and of a angle with a shortening of coagulation time and of coagulation rate.
Conclusions: The coagulation profile and the thromboelastography have a high sensitivity and a low specificity to diagnose a spread intravascular coagulation and to assess the risk of thrombosis in a patient with severe sepsis.


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