Álvarez VM, Díaz MD, Rodríguez RR, Morier DL, Guzmán TMG

Language: Spanish
References: 29
Page: 132-142
PDF size: 182.99 Kb.

ABSTRACT

Introduction: host immunity plays an important role in determining the development of dengue infections and the severe form of the disease. However, other factors, such as the variation between viral strains, are also involved in this complex pathogenesis mechanism.
Objectives: evaluate the neutralizing capacity of a number of sera from postconvalescing patients against two dengue 4 strains from the same genotype.
Methods: examination was conducted of sera from 68 individuals with dengue fever and 35 with dengue hemorrhagic fever.
Results: neutralizing antibody titers were low in the sera analyzed. Different neutralizing capacity was found between the two dengue 4 strains from genotype II. Significant differences were observed between neutralizing antibody titers in sera from individuals with secondary infection and with the severe form of the disease.
Conclusions: results reveal the complex nature of the neutralizing antibodies produced after a dengue infection with different strains of the same serotype, leading to diverse results by this technique, which could be the cause of the continued transmission of multiple dengue strains.

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