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ISSN 2007-6452 (Print)

2014, Number 2

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Investigación en Discapacidad 2014; 3 (2)

Use of mesenchymal stem cells in osteoarthritis

Esquivel-Solís H, Canales-Aguirre AA, Neri-Gómez T, Díaz-Martínez NE

Language: Spanish
References: 61
Page: 77-86
PDF size: 254.56 Kb.


ABSTRACT

Joint pain is often caused by cartilage degeneration (osteoarthritis), a disease that represents a serious medical problem affecting an important proportion of adults in Mexico. Almost none of the current therapies employed to treat cartilage lesions has provided satisfactory results in the long term because they neither solve the problem nor interrupt the progression of the degenerative process. In the last decades, tissue engineering aimed at achieving cartilage regeneration has emerged as a promising technique. This is due to recent advances in materials science on the use of biodegradable and biocompatible implants, which has permitted the development of artificial extracellular matrices with features very similar to those of native tissue. Scaffolds of extracellular matrices in combination with transplantation of autologous mesenchymal stem cells have permitted the restoration of damaged cartilage with a novel technique that offers a promising avenue for cartilage tissue regeneration. The goal of this review is to provide an overview of the current knowledge in the field of articular cartilage regeneration based on the use of extracellular matrix scaffolds and mesenchymal stem cell implants.


REFERENCES

  1. Lawrence JS, Bremner JM, Bier F, Osteo-arthrosis. Prevalence in the population and relationship between symptoms and x-ray changes. Ann Rheum Dis. 1966; 25: 1-24.

  2. Miralles G, Baudoin R, Dumas D, Baptiste D, Hubert P, Stoltz JF et al. Sodium alginate sponges with or without sodium hyaluronate: in vitro engineering of cartilage. Journal of Biomedical Materials Research. 2001; 57: 268-278.

  3. Genes NG, Rowley JA, Mooney DJ, Bonassar LJ. Effect of substrate mechanics on chondrocyte adhesion to modified alginate surfaces. Archives of Biochemistry and Biophysics. 2004; 422: 161-167.

  4. Park H, Temenoff JS, Holland TA, Tabata Y, Mikos AG. Delivery of TGF-beta 1 and chondrocytes via injectable, biodegradable hydrogels for cartilage tissue engineering applications. Biomaterials. 2005; 26: 7095-7103.

  5. Muller FA, Muller L, Hofmann I, Greil P, Wenzel MM, Staudenmaier R. Cellulose-based scaffold materials for cartilage tissue engineering. Biomaterials. 2006; 27: 3955-3963.

  6. Vinatier C, Magne D, Moreau A, Gauthier O, Malard O, Vignes-Colombeix C et al. Engineering cartilage with human nasal chondrocytes and a silanized hydroxypropyl methylcellulose hydrogel. Journal of Biomedical Materials Research. 2007; 80A: 66-74.

  7. Lee CR, Breinan HA, Nehrer S, Spector M. Articular cartilage chondrocytes in type I and type II collagen-GAG matrices exhibit contractile behavior in vitro. Tissue Engineering. 2000; 6: 555-565.

  8. Lee CR, Grodzinsky AJ, Spector A. Biosynthetic response of passaged chondrocytes in a type II collagen scaffold to mechanical compression. Journal of Biomedical Materials Research. 2003; 64A: 560-569.

  9. Liu X, Xu Y, Chen S, Tan Z, Xiong K, Li Y, Ye Y, Luo ZP, He F, Gong Y. Rescue of proinflammatory cytokine-inhibited chondrogenesis by the antiarthritic effect of melatonin in synovium mesenchymal stem cells via suppression of reactive oxygen species and matrix metalloproteinases. Free Radic Biol Med. 2014; 68: 234-46.

  10. De Franceschi L, Grigolo B, Roseti L, Facchini A, Fini M, Giavaresi G et al. Transplantation of chondrocytes seeded on collagen-based scaffold in cartilage defects in rabbits. Journal of Biomedical Materials Research. 2005; 75A: 612-622.

  11. Li Q, Williams CG, Sun DD, Wang J, Leong K, Elisseeff JH. Photocross linkable polysaccharides based on chondroitin sulfate. Journal of Biomedical Materials Research. 2004; 68: 28-33.

  12. Fan HB, Hu YY, Zhang CL, Li XS, Lv R, Qin L et al. Cartilage regeneration using mesenchymal stem cells and a PLGA-gelatin/chondroitin/hyaluronate hybrid scaffold. Biomaterials. 2006; 27: 4573-4580.

  13. Matsushita M1, Kitoh H, Kaneko H, Mishima K, Kadono I, Ishiguro N, Nishimura G. A novel SOX9 H169Q mutation in a family with overlapping phenotype of mild campomelic dysplasia and small patella syndrome. Am J Med Genet. 2013; 161 (10): 2528-2534.

  14. Liao J1, Hu N1, Zhou N1, Lin L1, Zhao C1, Yi S1 et al. Sox9 potentiates BMP2-induced chondrogenic differentiation and inhibits bmp2-induced osteogenic differentiation. PLoS One. 2014; 9 (2): 89025.

  15. Iyama K, Ninomiya Y, Olsen BR, Linsenmayer TF, Trelstad RL, Hayashi M. Spatiotemporal pattern of type X collagen gene expression and collagen deposition in embryonic chick vertebrae undergoing endochondral ossification. Anat Rec. 1991; 229 (4): 462-472.

  16. Pratap J, Galindo M, Zaidi SK, Vradii D, Bhat BM, Robinson JA et al. Cell growth regulatory role of Runx2 during proliferative expansion of preosteoblasts. Cancer Res. 2003; 63 (17): 5357-5362.

  17. Galindo M, Pratap J, Young DW, Hovhannisyan H, Im HJ, Choi JY et al. The bone-specific expression of Runx2 oscillates during the cell cycle to support a G1-related antiproliferative function in osteoblasts. J BiolChem. 2005; 280 (21): 20274-20285.

  18. Brittberg M, Lindahl A, Nilsson A, Ohlsson C, Isaksson O, Peterson L. Treatment of deep cartilage defects in the knee with autologous chondrocyte transplantation. N Engl J Med. 1994; 331 (14): 889-895.

  19. Bahuaud J, Maitrot RC, Bouvet R, Kerdiles N, Tovagliaro F, Synave J et al. Implantation of autologous chondrocytes for cartilagenous lesions in young patients. A study of 24 cases. Chirurgie. 1998; 123 (6): 568-571.

  20. Goodstone NJ, Cartwright A, Ashton B. Effects of high molecular weight hyaluronan on chondrocytes cultured within a resorbable gelatin sponge. Tiss Engin. 2004; 10: 621-631.

  21. Xia WY, Liu W, Cui L, Liu YC, Zhong W, Liu DL et al. Tissue engineering of cartilage with the use of chitosan gelatin complex scaffolds. Journal of Biomedical Materials Research Part B-Applied Biomaterials. 2004; 71B: 373-380.

  22. Hoshikawa A, Nakayama Y, Matsuda T, Oda H, Nakamura K, Mabuchi K. Encapsulation of chondrocytes in photopolymerizable styrenated gelatin for cartilage tissue engineering. Tiss Engin. 2006; 12: 2333-2341.

  23. Sechriest VF, Miao YJ, Niyibizi C, Westerhausen-Larson A, Matthew, HW, Evans CH et al. GAG-augmented polysaccharide hydrogel: a novel biocompatible and biodegradable material to support chondrogenesis. J of Biomed Mat Res. 1999; 49: 534-541.

  24. Nettles DL, Elder SH, Gilbert JA, Potential use of chitosan as a cell scaffold material for cartilage tissue engineering. Tiss Engin. 2002; 8: 1009-1016.

  25. García-Carvajal Z, Garciadiego-Cázares D, Parra-Cid C, Aguilar-Gaytán R, Velasquillo C, Ibarra C et al. Cartilage tissue engineering: the role of extracellular matrix (ECM) and novel strategies. En: Regenerative medicine and tissue engineering. 2013. ISBN: 978-953-51-1108-5.

  26. Li WJ, Danielson KG, Alexander PG, Tuan RS. Biological response of chondrocytes cultured in three-dimensional nanofibrous poly (epsiloncaprolactone) scaffolds. J of Biomed Mat Res. 2003; Part A 67A: 1105-1114.

  27. Shin HJ, Lee CH, Cho IH, Kim YJ, Lee YJ, Kim IA et al. Electrospun PLGA nanofiber scaffolds for articular cartilage reconstruction: mechanical stability, degradation and cellular responses under mechanical stimulation in vitro. J of Biomat. 2006; 17: 103-119.

  28. Uematsu K, Hattori K, Ishimoto Y, Yamauchi J, Habata T, Takakura Y et al. Cartilage regeneration using mesenchymal stem cells and a three-dimensional poly-lactic-glycolic acid (PLGA) scaffold. Biomaterials. 2005; 26: 4273-4279.

  29. Elisseeff J, McIntosh W, Anseth K, Riley S, Ragan P, Langer R. Photoencapsulation of chondrocytes in poly (ethylene oxide)-based semi interpenetrating networks. J of Biomed Mat Res. 2000; 51: 164-171.

  30. Bryant SJ, Bender RJ, Durand KL, Anseth KS. Encapsulating chondrocytes in degrading PEG hydrogels with high modulus: engineering gel structural changes to facilitate cartilaginous tissue production. Biotech and Bioeng. 2004; 86: 747-755.

  31. Holland TA, Tabata Y, Mikos AG. Dual growth factor delivery from degradable oligo (poly [ethylene glycol] fumarate) hydrogel scaffolds for cartilage tissue engineering. J of ContRel. 2005; 101: 111-125.

  32. Liao E, Yaszemski M, Krebsbach P, Hollister S. Tissue-engineered cartilage constructs using composite hyaluronic acid/collagen I hydrogels and designed poly (propylene fumarate) scaffolds. Tiss Engin. 2007; 13: 537-550.

  33. Grad S, Kupcsik L, Gorna K, Gogolewski S, Alini M. The use of biodegradable polyurethane scaffolds for cartilage tissue engineering: potential and limitations. Biomaterials. 2003; 24: 5163-5171.

  34. Liu Y, Webb K, Kirker KR, Bernshaw NJ, Tresco PA, Gray SD et al. Composite articular cartilage engineered on a chondrocyte seeded aliphatic polyurethane sponge. Tiss Engin. 2004; 10: 1084-1092.

  35. Chia SL, Gorna K, Gogolewski S, Alini M. Biodegradable elastomeric polyurethane membranes as chondrocyte carriers for cartilage repair. Tiss Engin. 2006; 12: 1945-1953.

  36. Martens PJ, Bryant SJ, Anseth KS. Tailoring the degradation of hydrogels formed from multivinyl poly (ethylene glycol) and poly (vinyl alcohol) macromers for cartilage tissue engineering. Biomacromol. 2003; 4: 283-292.

  37. Bryant SJ, Bender RJ, Durand KL, Anseth KS. Encapsulating chondrocytes in degrading PEG hydrogels with high modulus: engineering gel structural changes to facilitate cartilaginous tissue production. Biotech and Bioeng. 2004; 86: 747-755.

  38. Buda, R. Osteochondral lesions of the knee: a new one-step repair technique with bone marrow-derived cells. The J of Bone and Joint Surg Am. 2010; 92: 2-11.

  39. Matsumoto T. Articular cartilage repair with autologous bone marrow mesenchymal cells. J of Cell Physiol. 2010; 225: 291-295.

  40. Nejadnik H, Hui JH, Feng Choong EP, Tai BC, Lee EH. Autologous bone marrow derived mesenchymal stem cells versus autologous chondrocyte implantation: an observational cohort study. The Amer J of Sp Med. 2010; 38: 1110-1116.

  41. Haleem AM. The clinical use of human culture-expanded autologous bone marrow mesenchymal stem cells transplanted on platelet-rich fibrin glue in the treatment of articular cartilage defects: a pilot study and preliminary results. Cartilage. 2010; 1: 253-261.

  42. Kasemkijwattana C. Autologous bone marrow mesenchymal stem cells implantation for cartilage defects: two cases report. J of the Med Assoc of Thail. 2011; 94: 395-400.

  43. Davatchi F, Abdollahi BS, Mohyeddin M, Shahram F, Nikbin B. Mesenchymal stem cell therapy for knee osteoarthritis. Preliminary report of four patients. Inter J of Rheum Dis. 2011; 14: 211-215.

  44. Koh YG. Mesenchymal stem cell injections improve symptoms of knee osteoarthritis. Arthroscopy. 2013; 29: 748-755.

  45. Hauser RA, Orlofsky A. Regenerative injection therapy with whole bone marrow aspirate for degenerative joint disease: a case series. Clin Med Insights Arthritis Musculoskelet Disord. 2013; 6: 65-72.

  46. Burdick JA, Chung C, Jia XQ, Randolph MA, Langer R. Controlled degradation and mechanical behavior of photopolymerized hyaluronic acid networks. Biomacromolecules. 2005; 6: 386-391.

  47. Chung C, Mesa J, Randolph MA, Yaremchuk M, Burdick JA. Influence of gel properties on neocartilage formation by auricular chondrocytes photoencapsulated in hyaluronic acid networks. J of Biom Mat Res. 2006; 77: 518-525.

  48. Mauck RL, Yuan X, Tuan RS. Chondrogenic differentiation and functional maturation of bovine mesenchymal stem cells in long-term agarose culture. Osteoart and Cart. 2006; 14: 179-189.

  49. Genes NG, Rowley JA, Mooney DJ, Bonassar LJ. Effect of substrate mechanics on chondrocyte adhesion to modified alginate surfaces. Arch of Biochem and Bioph. 2004; 422: 161-167.

  50. Park H, Temenoff JS, Holland TA, Tabata Y, Mikos AG. Delivery of TGF-beta 1 and chondrocytes via injectable, biodegradable hydrogels for cartilage tissue engineering applications. Biomaterials. 2005; 26: 7095-7103.

  51. Muller FA, Muller L, Hofmann I, Greil P, Wenzel MM, Staudenmaier R. Cellulose-based scaffold materials for cartilage tissue engineering. Biomaterials. 2006; 27: 3955-3963.

  52. Vinatier C, Magne D, Moreau A, Gauthier O, Malard O, Vignes-Colombeix C et al. Engineering cartilage with human nasal chondrocytes and a silanized hydroxypropyl methylcellulose hydrogel. J of Biomed Mat Res. 2007; 80A: 66-74.

  53. De Franceschi L, Grigolo B, Roseti L, Facchini A, Fini M, Giavaresi G et al. Transplantation of chondrocytes seeded on collagen based scaffold in cartilage defects in rabbits. J of Biomed Mat Res. 2005; 75A: 612-622.

  54. Li Q, Williams CG, Sun DD, Wang J, Leong K, Elisseeff JH. Photocross linkable polysaccharides based on chondroitin sulfate. J of Biomed Mat Res. 2004; 68: 28-33.

  55. Fan HB, Hu YY, Zhang CL, Li XS, Lv R, Qin L et al. Cartilage regeneration using mesenchymal stem cells and a PLGA-gelatin/chondroitin/hyaluronate hybrid scaffold. Biomaterials. 2006; 27: 4573-4580.

  56. Uematsu K, Hattori K, Ishimoto Y, Yamauchi J, Habata T, Takakura Y et al. Cartilage regeneration using mesenchymal stem cells and a three-dimensional poly-lactic-glycolic acid (PLGA) scaffold. Biomaterials. 2005; 26: 4273-4279.

  57. Chen X, Zhang F, He X, Xu Y, Yang Z, Chen L, Chondrogenic differentiation of umbilical cord-derived mesenchymal stem cells in type I collagen-hydrogel for cartilage engineering. Injury Int J Care Injured. 2013; 44: 540-549.

  58. Hendriks JA, Moroni L, Riesle J, deWijn JR, van Blitterswijk CA. The effect of scaffold-cell entrapment capacity and physico-chemical properties on cartilage regeneration. Biomaterials. 2013; 34: 4259-4265.

  59. Du M, Liang H, MouCh, Li X, Sun J, Zhuang Y et al. Regulation of human mesenchymal stem cells differentiation into chondrocytes in extracellular matrix-based hydrogel scaffolds. Biointerfaces. 2014; 114: 316-323.

  60. Coates EE, Riggin CN, Fisher JP, Photocross-linked alginate with hyaluronic acid hydrogels as vehicles for mesenchymal stem cell encapsulation and chondrogenesis. J of Biomed Mat Res. 2013; 101: 1962-1970.

  61. Brochhausen C, Sanchez N, Halstenberg S, Zehbe R, Watzer B, Schmitt VH et al. Phenotypic differentiation and cell cluster formation of cultured human articular chondrocytes in three-dimensional oriented gelatin scaffold in the presence of PGE2 - first results of a pilot study. J of Biomed Mat Res. 2013; 101: 2374-2382.




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