2014, Number 3
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Cir Cir 2014; 82 (3)
Local recurrence based on size after conservative surgery in breast cancer stage T1-T2. A population-based study
Martínez-Ramos D, Fortea-Sanchis C, Escrig-Sos J, Prats-de Puig M, Queralt-Martín R, Salvador-Sanchis JL
Language: Spanish
References: 14
Page: 252-261
PDF size: 404.16 Kb.
ABSTRACT
Background: Conservative surgery can be regarded as the standard
treatment for most early stage breast tumors. However, a minority of
patients treated with conservative surgery will present local or locoregional
recurrence. Therefore, it is of interest to evaluate the possible
factors associated with this recurrence.
Methods: A population-based retrospective study using data from the
Tumor Registry of Castellón (Valencia, Spain) of patients operated on
for primary nonmetastatic breast cancer between January 2000 and
December 2008 was designed. Kaplan-Meier curves and log-rank test
to estimate 5-year local recurrence were used. Two groups of patients
were defined, one with conservative surgery and another with nonconservative
surgery. Cox multivariate analysis was conducted.
Results: The total number of patients was 410. Average local recurrence
was 6.8%. In univariate analysis, only tumor size and lymph node
involvement showed significant differences. On multivariate analysis,
independent prognostic factors were conservative surgery (hazard ratio
[HR] 4.62; 95% confidence interval [CI]: 1.12-16.82), number of positive
lymph nodes (HR 1.07; 95% CI: 1.01-1.17) and tumor size (in mm)
(HR 1.02; 95% CI: 1.01-1.06).
Conclusions: Local recurrence after breast-conserving surgery is higher
in tumors ›2 cm. Although tumor size should not be a contraindication
for conservative surgery, it should be a risk factor to be considered.
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