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Instituto Nacional de Neurología y Neurocirugía

2013, Number 4

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Arch Neurocien 2013; 18 (4)

In silico demonstration and characterization of the stochastic resonance phenomena in a NMDA type nociceptive synapsis of the spinal dorsal horn

Henríquez Y, Eblen-Zajjur A

Language: Spanish
References: 33
Page: 182-189
PDF size: 359.59 Kb.


ABSTRACT

Aim: nociceptive primary afferents establish synapses in the spinal dorsal horn (SDH) expressing mainly glutamatergic strongly excitatory NMDA type ionotropic channels. SDH postsynaptic neurons generate discharges inmersed in different noise levels which is classically considerated a signal transmission adverse factor. Material and method: in the present study, the effects of different noise levels (NL) was evaluated on a experimentally described model of NMDA type synapse between nociceptive SDH neurons. Pre and postsinaptic number of spikes, interspike intervals (ISI) and the post/presynaptic spike quotient were studied with a neuronal network simulator (Neurosim: Network v 1.2a.). The NL was progresssively increased (0 to ±5mV) in both spontaneous activity and evoked by a electrical stimulus (pulse ±29nA). Results: It was found a proportional increase of synaptic efficiency with NL with a logaríthmic function: Post/Pre Spike Quotient = 3,38+0,26NL- 0,029NL2 (r=+0,67; P‹0,05), the ISI for presynaptic: ISI = 14,33- 1,33NL+0,06NL2 but also postsynaptic: ISI= 6,66- 0,85NL+0,06NL2 showed a proportional decrease with NL (r=-0,72 and r=-0,79; respectively P‹0,05). Conclusion: these results strongly suggest, for the first time, that the NL increases the synaptic efficiency in the model of NMDA type synapse between nociceptive SDH neurons, this phenomenon of interest in nociception, named stochastic resonance, was described first in others places of the central nervous system.


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