medigraphic.com
ISSN 0016-3813 (Print)

2005, Number 1

<< Back Next >>

Gac Med Mex 2005; 141 (1)

Lichen planus and hepatitis C virus. Is there an association?

Luis-Montoya P, Cortés-Franco R, Vega-Memije ME

Language: Spanish
References: 30
Page: 23-26
PDF size: 35.91 Kb.


ABSTRACT

Introduction: The etiology of lichen planus (LP) is unknown. The possible role of hepatitis C virus (HCV) has been studied with controversial results. Materials and Methods: The aim of this study was to determine the prevalence of HCV infection in 36 patients with lichen planus (LP) confirmed by histopathology, 12 in a retrospective way, and 24 in a prospective one. The controls were 60 consecutive blood donors from the Blood Bank of the hospital. Third generation enzyme immunoassay screening test was employed for determination of antibodies against HCV. Results: A prevalence of HCV infection of 2.77% in LP patients, and 0% in control group (Fisher’s exact test - p=0.375). Conclusions: We found in our patients with LP a lower prevalence of positive serology for HCV than that reported in the literature. Since all studies have found patients with LP without infection by HCV, we think that other factors in the pathogenesis of this dermatosis need to be studied.


REFERENCES

  1. Arndt KA. Lichen planus. In: Fitzpatrick TB, Eisen AZ, Wolff K, Freedberg IM, Aausten KF, eds. Dermatology in General Medicine, 5th ed. New York: McGraw Hill, 1999:561-577.

  2. Boyd AS, Neldner KH. Lichen planus. J Am Acad Dermatol 1991;25:593-619.

  3. Pawlotsky J-M, Dhumeaux D, Bagot M. Hepatitis C virus in Dermatology. Arch Dermatol 1995;131:1185-1193.

  4. Mokni M, Rybojad M, Puppin D et al. Lichen planus and hepatitis C virus. J Am Acad Dermatol 1991;24:792.

  5. Cheney CP, Chopra S, Graham C. Hepatitis C. Infect Dis Clin North Am 2000;15(3):633-667.

  6. Islas S, Yamaguchi K, Nishimura Y et al. Antibody to hepatitis C virus in volunteer blood donors of the Hospital de Especialidades National Medical Center, Mexico city. Arch Med Res 1994;25(3):361-362.

  7. Souto-Meirino CA, Simon-Domínguez J, Pulido-Priego M et al. The prevalence of markers for hepatitis A, B and C in a hospital in Mexico. Salud Pública Mex 1994 may-jun; 36(3):257-262.

  8. Mendez-Sánchez N, Baptista-González H, Sánchez Gomez et al. The prevalence of hepatitis B and C in blood donors in a 3rd level hospital of Mexico city. Salud Pública Mex 1999 nov-dec; 41(6):475-478.

  9. Miralles J, Pujol M, De Moragas JM. Liquen plano y hepatitis C. Descripción de 13 casos. Actas Dermosifiliogr 1994;85(10):603-606.

  10. Nagao Y, Sata M, Tanikawa K, Itoh K, Kameyama T. Lichen planus and hepatitis C virus in the northern Kyushu region of Japan. Eur J Clin Invest 1995 Dec;25(12):910-914.

  11. Tanei R, Watanabe K, Nishiyama S. Clinical and histopathologic analysis of the relationship between lichen planus and chronic hepatitis C. J Dermatol 1995;22:316-323.

  12. Bellman B, Reddy R, Falanga V. Lichen planus associated with hepatitis C. Lancet 1995;346:1234.

  13. Bellman B, Reddy R, Falanga V. Generalized lichen planus associated with hepatitis C virus immunoreactivity. J Am Acad Dermatol 1996;35(5):770-772.

  14. Carrozzo M et al. Hepatitis C virus infection in Italian patients with oral lichen planus: a prospective case-control study. J Oral Pathol Med 1996 Nov; 25(10):527-533.

  15. Sánchez-Pérez J, De Castro M, Buezo GF et al. Lichen planus and hepatitis C virus: prevalence and clinical presentation of patients with lichen planus and hepatitis C virus infection. Br J Dermatol 1996;134:715-719.

  16. Imhof M, Popal H, Lee JH et al. Prevalence of hepatitis C virus antibodies and evaluation of hepatitis C virus genotypes in patients with lichen planus. Dermatology 1997;195:1-5.

  17. Mignogna MD, Lo Muzio L, Favia G et al. Oral lichen planus and HCV infection: a clinical evaluation of 263 cases. Int J Dermatol 1998;37:575-578.

  18. Chuang T-Y, Stitle L, Brashear R, Lewis C. Hepatitis C virus and lichen planus: A case-control study of 340 patients. J Am Acad Dermatol 1999;41(5):787-789.

  19. Kirtak N, Inaloz HS, Ozgoztasi, Erbagci Z. The prevalence of hepatitis C virus infection in patients with lichen planus in Gaziantep region of Turkey. Eur J Epidemiol 2000;16(12):1159-1161.

  20. Beaird LM, Kahloon N, Franco J, Fairley JA. Incidence of hepatitis C in lichen planus. J Am Acad Dermatol 2001;44(2):311-312.

  21. Figueiredo LC, Carrilho FJ, de Andrage HF, Migliari DA. Oral lichen planus and hepatitis C virus infection. Oral Dis 2002;8(1):42-46.

  22. Gimenez-García R, Pérez-Castrillón JL. Lichen planus and hepatitis C virus infection. J Eur Acad Dermatol & Venereol 2003;17(3):291-295.

  23. Mahboob A, Haroon TS, Iqbal Z, Iqbal F, Butt AK. Frequency of anti-HCV antibodies in patients with lichen planus. J Coll Physicians Surg Park 2003 May;13(5):248-251.

  24. Franco A, Jurado F. Correlación clínico-serológica del liquen plano y el virus de la hepatitis C. Dermatología Rev Mex 2001;45(1):19-28.

  25. Cribier B, Garnier C, Laustriat D, Heid E. Lichen planus and hepatitis C virus infection: An epidemiology study. J Am Acad Dermatol 1994;31(6):1070-1071.

  26. Dupin N. Oral lichen planus and hepatitis C virus infection: a fortuitus association?. Arch Dermatol 1997;133:1052-1053.

  27. Ingafou M, Porter SR, Scully C, Teo CG. No evidence of HCV infection or liver disease in British patients with oral lichen planus. Int J Oral Maxillofac Surg 1998;27(1):65-66.

  28. Tucker SC, Coulson IH. Lichen planus is not associated with hepatitis C virus infection in patients from north west England. Acta Derm Venereol 1999; 79: 378-379.

  29. van der Meij EH, van der Waal I. Hepatitis C virus infection and oral lichen planus, a report from Netherlands. J Oral Pathol Med 2000;29(6):255-258.

  30. Daramola OOM, George AO, Ogunbiyi AO. Hepatitis C virus and lichen planus in Nigerians: any relationship?. Int J Dermatol 2002;41;217-219.




2020     |     www.medigraphic.com