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2014, Number 1

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Medisur 2014; 12 (1)

Preclinical Evaluation of Hepatoprotective Activity of Ocimum basilicum L. and Allium sativum L.

Bermúdez TD, Boffill CM, Betancourt ME, Escobar RR, Igualada CI, Alonso CB

Language: Spanish
References: 26
Page: 51-62
PDF size: 265.03 Kb.


ABSTRACT

Background: finding natural treatments designed to protect the liver from the damaging effects of hepatotoxins is an important topic in medical and pharmaceutical research.
Objective: to pre-clinically evaluate the hepatoprotective activity of the species Ocimum basilicum L. and Allium sativum L. in an animal model of acetaminophen-induced toxicity.
Results: the biochemical parameters showed highly significant differences, but only three groups had results similar to the untreated control group. No macroscopic changes in the liver were confirmed. Microscopically, the absence of histopathological changes prevailed in the groups treated with Ocimum basilicum L. at both doses and Allium sativum L. at 200mg/kg; slight damage was observed by administering 400mg/kg of Allium sativum L., with significant differences from the untreated control group.
Conclusions: soft extracts of the species Ocimum basilicum L. and Allium sativum L. at a dose of 200mg/kg have greater hepatoprotective activity against the toxic action of acetaminophen.


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