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2005, Number 4

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Rev Inst Nal Enf Resp Mex 2005; 18 (4)

Immunological role of epithelial cells of the lung

Rivas-Santiago BT, Torres RM, Bobadilla LK, Sada DE

Language: Spanish
References: 37
Page: 321-326
PDF size: 88.84 Kb.


ABSTRACT

The respiratory tract is one of the main systems which is in perennial contact with a wide variety of pathogenic microorganisms; however, infection is seldom produced due to its innate immune response. Respiratory tract epithelial cells play a very important role to avoid colonization of the lung by infectious agents, because they recognize microbial molecules through very specialized receptors, such as toll-like receptors; moreover, these cells posses a broad variety of molecules which are related to local immunity. Respiratory tract epithelial cells produce chemokines, antimicrobial peptides and other proinflammatory molecules that prevent the establishment of pathogenic microorganisms.


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