2005, Número 4
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Rev Inst Nal Enf Resp Mex 2005; 18 (4)
Papel de las células epiteliales en la respuesta inmune del pulmón
Rivas-Santiago BT, Torres RM, Bobadilla LK, Sada DE
Idioma: Español
Referencias bibliográficas: 37
Paginas: 321-326
Archivo PDF: 88.84 Kb.
RESUMEN
El sistema respiratorio se encuentra en contacto con agentes patógenos; sin embargo, gracias a la respuesta inmune innata de éste, sólo en raras ocasiones se produce la enfermedad.
Las células epiteliales del tracto respiratorio desempeñan un papel importante para evitar la colonización del pulmón por agentes infecciosos, identificando a los microorganismos a través de receptores especializados como los toll-like. Asimismo, son capaces de secretar citocinas, péptidos antimicrobianos y otras moléculas proinflamatorias, las cuales evitan el establecimiento de patógenos.
REFERENCIAS (EN ESTE ARTÍCULO)
Medzhitov R, Janeway CA Jr. Innate immunity: impact on the adaptative immune response. Curr Opin Immunol 1997;9:4-9.
Diamond G, Legarda D, Ryan LK. The innate immune response of the respiratory epithelium. Immunol Rev 2000;173:27-38.
Netea MG, Van der Meer JW, Kullberg BJ. Toll-like receptors as an escape mechanism from the host defense. Trends Microbiol 2004;12:484-488.
Cook DN, Pisetsky DS, Schwartz DA. Toll-like receptors in the pathogenesis of human disease. Nat Immunol 2004;5:975-979.
Hogg JC. Pathophysiology of airflow limitation in chronic obstructive pulmonary disease. Lancet 2004;364: 709-721.
Takii T, Abe C, Tamura A, et al. Interleukin-1 or tumor necrosis factor-alpha augmented the cytotoxic effect of mycobacteria on human fibroblasts: application to evaluation of pathogenesis of clinical isolates of Mycobacterium tuberculosis and M. avium complex. J Interferon Cytokine Res 2001;21:187-196.
Haslett C. Granulocyte apoptosis and its role in resolution and control of lung inflammation. Am J Respir Crit Care Med 1999;160(5 Pt 2):5-11.
Hiemstra PS, van Wetering S, Stolk J. Neutrophil serine proteinases and defensins in chronic obstructive pulmonary disease: effects on pulmonary epithelium. Eur Respir J 1998;12:1200-1208.
Agerberth B, Charo J, Werr J, et al. The human antimicrobial and chemotactic peptides LL-37 and alpha-defensins are expressed by specific lymphocyte and monocytes populations. Blood 2000;96:3086-3093.
Zhang H, Porro G, Orzech N, Mullen B, Liu M, Slutsky AS. Neutrophil defensins mediate acute inflammatory response and lung dysfunction in dose-related fashion. Am J Physiol Lung Cell Mol Physiol 2001; 280:L947-L954.
Cunliffe RN, Mahida YR. Expression and regulation of antimicrobial peptides in the gastrointestinal tract. J Leukoc Biol 2004;75:49-58.
Quayle AJ, Porter EM, Nussbaum AA, et al. Gene expression, immunolocalization, and secretion of human defensin-5 in human female reproductive tract. Am J Pathol 1998;152;1247-1258.
Schutte BC, Mitros JP, Bartlett JA, et al. Discovery of five conserved beta-defensin gene clusters using a computational search strategy. Proc Natl Acad Sci USA 2002;99:2129-2133. Erratum in: Proc Natl Acad Sci USA 2002;99:14611.
Doherty TM, Arditi M. TB, or not TB: that is the question-does TLR signaling hold the answer? J Clin Invest 2004;114:1699-1703.
Alcorn JF, Wright JR. Surfactant protein A inhibits alveolar macrophage cytokine production by CD14-independent pathway. Am J Physiol Lung Cell Mol Physiol 2004;286:129-136.
Schutte BC, McCray PB Jr. beta-defensins in lung host defense. Annu Rev Physiol 2002;64:709-748.
Biragyn A, Ruffini PA, Leifer CA, et al. Toll-like receptor 4-dependent activation of dendritic cells by beta-defensin 2. Science 2002;298:1025-1029.
Davidson DJ, Currie AJ, Reid GS, et al. The cationic antimicrobial peptide LL-37 modulates dendritic cell differentiation and dendritic cell-induced T cell polarization. J Immunol 2004;172:1146-1156.
Van Wetering S, Tjabringa GS, Hiemstra PS. Interactions between neutrophil-derived antimicrobial peptides and airway epithelial cells. J Leukoc Biol 2005;77:444-450.
Bals R, Hiemstra PS. Innate immunity in the lung: how epithelial cells fight against respiratory pathogens. Eur Respir J 2004;23:327-333.
Frantz S, Vincent KA, Feron O, Kelly RA. Innate immunity and angiogenesis. Circ Res 2005;96:15-26. Erratum in: Circ Res 2005;96:e7.
Reddy KV, Yedery RD, Aranha C. Antimicrobial peptides: premises and promises. Int J Antimicrob Agents 2004;24:536-547.
Ganz T. Defensins: antimicrobial peptides of vertebrates. C R Biol 2004;327:539-549.
Koczulla AR, Bals R. Antimicrobial peptides: current status and therapeutic potential. Drugs 2003;63:389-406.
Wilson CL, Ouellette AJ, Satchell DP, et al. Regulation of intestinal alpha-defensin activation by the metalloproteinase matrilysin in innate host defense. Science 1999;286:113-117.
Harder J, Meyer-Hoffert U, Teran LM, et al. Mucoid Pseudomonas aeruginosa, TNF-alpha, and IL-1beta, but not IL-6, induce human beta-defensin-2 in respiratory epithelia. Am J Respir Cell Mol Biol 2000;22: 714-721.
Duits LA, Ravensbergen B, Rademaker M, Hiemstra PS, Nibbering PH. Expression of beta-defensin 1 and 2 mRNA by human monocytes, macrophages and dendritic cells. Immunology 2002;106:517-525.
Bals R, Weiner DJ, Meegalla RL, Accurso F, Wilson JM. Salt-independent abnormality of antimicrobial activity in cystic fibrosis airway surface fluid. Am J Respir Cell Mol Biol 2001;25:21-25.
Moser C, Weiner DJ, Lysenko E, Bals R, Weiser JN, Wilson JM. beta-Defensin 1 contributes to pulmonary innate immunity in mice. Infect Immun 2002;70: 3068-3072.
Bals R, Weiner DJ, Meegalla RL, Wilson JM. Transfer of a cathelicidin peptide antibiotic gene restores bacterial killing in a cystic fibrosis xenograft model. J Clin Invest 1999;103:1113-1117.
Cole AM, Waring AJ. The role of defensins in lung biology and therapy. Am J Respir Med 2002;1:249-259.
Cole AM, Tahk S, Oren A, et al. Determinants of Staphylococcus aureus nasal carriage. Clin Diagn Lab Immunol 2001;8:1064-1069.
Cao Y, Tao JQ, Bates SR, Beers MF, Haczku A. IL-4 induces production of the lung collectin surfactant protein-D. J Allergy Clin Immunol 2004;113:439-444.
De Astorza B, Cortes G, Crespi C, Saus C, Rojo JM, Alberti S. C3 promotes clearance of Klebsiella pneumoniae by A549 epithelial cells. Infect Immun 2004;72:1767-1774.
Castro-Garza J, King CH, Swords WE, Quinn FD. Demonstration of spread by Mycobacterium tuberculosis bacilli in A549 epithelial cell monolayers. FEMS Microbiol Lett 2002;212:145-149.
Bermudez LE, Goodman J. Mycobacterium tuberculosis invades and replicates within type II alveolar cells. Infect Immun 1996;64:1400-1406.
Roy S, Sharma S, Sharma M, Aggarwal R, Bose M. Induction of nitric oxide release from the human alveolar epithelial cell line A549: an in vitro correlate of innate immune response to Mycobacterium tuberculosis. Immunology 2004;112:471-480.