2013, Number 3
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Arch Neurocien 2013; 18 (3)
Relationship between gender and non motor symptoms in Parkinson’s disease patients
Martínez-Ramírez D, Rodríguez-Violante M, Cervantes-Arriaga A, Morales-Briceño H
Language: Spanish
References: 21
Page: 138-141
PDF size: 76.82 Kb.
ABSTRACT
Non motor-symptoms (NMS) of Parkinson’s disease are considered part of the clinical spectrum of the disease, at
times presenting in the pre-clinical stage. These symptoms cause important morbidity having a great impact on
quality of life. There is little information in literature about relationship between gender and NSM.
Objective: determine
the relationship by gender in the frequency of non-motor symptoms.
Methods: Restrospective, longitudinal, descriptive
and analytic study of patients with Parkinson’s disease. NMS were determine with the “Non Motor Symptoms
Scale” (NMSS). Patients were divided in groups by gender and having the symptom or not. Chi-square test was
applied looking for association between variables. P was calculated for an alpha level of 0.05. SPSS Statistics 19
software was used for statistical anlaysis.
Results: 232 patients were questioned, 102 (44%) women, 130 (56%)
men. More common symptoms were, in women (p <0.05): nausea/vomit, constipation, pain, memory problems,
hallucinations, sadness, anxiety, light- headedness, falls, insomnia, while in men, sexual dysfunction was the most
common symptom.
Conclusion: we found significative differences in the prevalence of some of the NMS between
women and men. The results could be useful for future clinical studies.
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Zambito Marsala S, Tinazzi M, Vitaliani R, Recchia S, Fabris F, Marchini C, et al. Spontaneous pain, pain threshold, and pain tolerance in Parkinson’s disease. J Neurol 2011; 258:627-33.
Hanagasi HA, Akat S, Gurvit H, Yazici J, Emre M. Pain is common in Parkinson’s disease. Clin Neurol Neurosurg 2011; 113:11-3.
Barone P, Antonini A, Colosimo C, Marconi R, Morgante L, Avarello TP et al. The PRIAMO study: a multicenter assessment of nonmotor symptoms and their impact on quality of life in Parkinson’s disease. Mov Disord 2009;24:1641-49.
Solimeo S. Sex and gender in older adults’ experience of Parkinson’s disease. J Gerontol Soc Sci 2008;63B:S42-S48.
Gillies GE, McArthur S. Estrogen actions in the brain and the basis for differential action in men and women: a case for sexspecific medicines. Pharmacol Rey 2010;62:155-98.
Martinez-Martin P, Falup Pecurariu C, Odin P, van Hilten JJ, Antonini A, Rojo- Abuin JM, et al. Gender-related differences in the burden of non-motor symptoms in Parkinson’s disease. J Neurol 2012;doi 10.1007/s00415-011-6392-3.