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2013, Number 4

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Rev Hematol Mex 2013; 14 (4)

Efficacy and safety in the collection of hematopoietic stem cells from peripheral blood in pediatric donors using a central catether

Gutiérrez-Aguirre CH, Salazar-Riojas R, Cantú-Rodríguez O, González-Llano Ó, Ríos-Solís JE, Gómez-Almaguer D

Language: Spanish
References: 16
Page: 173-177
PDF size: 313.83 Kb.


ABSTRACT

Background: The apheresis procedure to obtain peripheral blood hematopoietic stem cells is gradually replacing the bone marrow harvest as the main procedure for obtaining cells for transplantation. In pediatric donors, it is recommended to use a central line for this procedure due to the advantages offered.
Objective: Analyze the results of procedures performed in pediatric apheresis donors by venous access via a jugular central catheter.
Methods: We retrospectively analyzed the outcome of apheresis procedures performed in pediatric donors of over 20 kg weight through a 7.5 Fr dual lumen central jugular catheter placed by ultrasound and fluoroscopy.
Results: Fifty-five donors were included, 36 for autologous transplant and 19 for allogeneic transplant. In autologous transplantation procedures, the median of blood volume processed, duration of apheresis and CD34+ cells collected per kilo of weight receptor was 11,986 mL, 217 minutes and 4.4 x 106 respectively. In allogeneic transplantation procedures, the median of blood volume processed, duration of apheresis and CD34+ cells collected per kilo of weight receptor was 15,014 ml, 230 minutes, and 7.6 x 106 respectively. No complications related to central catheter placement or during the cell collection procedure were observed. Eight patients required 2 apheresis procedures in order to collect the desired amount of CD34+.
Conclusion: The stem cell collection procedure using a central catheter guided by ultrasound and fluoroscopy is both effective and safe in pediatric donors.


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