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ISSN 1561-3070 (Electronic)

2013, Number 2

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Rev Cub Oftal 2013; 26 (2)

Confocal microscopy in refractive corneal surgery: is it a useful or an indispensable tool?

Rojas ÁE

Language: Spanish
References: 25
Page: 323-329
PDF size: 38.18 Kb.


ABSTRACT

Introduction: the morphometric study of the cornea after excimer laser refractive surgery has turned into a recurrent research topic worldwide in the last few years, with a view to achieving in vivo corneal tissue outcomes, and hence, to evaluating these state-of-the-art technologies.
Objective: to describe the corneal confocal microscopy uses in excimer laser refractive surgery.
Methods: an exploratory study was conducted, which took into account the publications of the most outstanding authors in the last five years, as well as the highest impact journals in this field. Infomed, particularly the Virtual Health Library (Ebsco, Hinari, PERii, SciELO Cuba, regional SciELO, PLoS Medicine, Pubmed Central, Biomed Central, DOAJ, Free Medical Journals). The information was summarized for the preparation of the final report.
Results: the different studies contained in this review yielded corneal density values by sublayers, corneal thicknesses, corneal cell and nerve characteristics, progression of these changes in time and statistical associations among the morphometric variables.
Conclusions: the ophthalmologist working in the corneal refractive surgery must master the corneal confocal microscopy and incorporate it into his/her daily practice as a preoperative and postoperative tool that has already become indispensable to raise the safety of this type of treatment. There is still a lot to be said and done in this regard; the research line of this topic points to higher development of this technique in the coming years, which can be restrained by the low access to this costly procedure in other countries.


REFERENCES

  1. Sonigo B, Iordanidou V, Chong-Sit D, Auclin F, Ancel JM, Labbé A, et al. In vivo corneal confocal microscopy comparison of intralase femtosecond láser and mechanical microkeratome for láser in situ keratomileusis. Br J Ophthalmol. 2006; 47(7):2803-11.

  2. Chen WL, Chang H, Hu FR. In vivo confocal microscopic evaluation of corneal wound healing after Epi-LASIK. Invest Ophthalmol Vis Sci. 2008;49(6):241623.

  3. Brugin A, Gambat. Central Corneal Thickness: Z-Ring Corneal Confocal Microscopy Versus Ultrasound Pachymetry. Cornea. 2007;26(3):303-7.

  4. Moilanen JAO, Vesaluoma M, Müller LJ, Tervo T. Long-Term corneal morphology after PRK by in vivo confocal microscopy. Invest Ophthalmol Vis Sci. 2003;44(3):1064-9.

  5. Moilanen JAO, Holopainen J, Vesaluoma MH, Tervo T. Corneal recovery after LASIK for high myopia: a 2-year prospective confocal microscopic study. Br J Ophthalmol. 2008;92(10):1397-402.

  6. Zhivov A, Stachs O, Stave J, Guthoff RF. In vivo three-dimensional confocal láser scanning microscopy of corneal surface and epithelium. Br J Ophthalmol. 2009;93(5):667-72.

  7. Ivarsen A, Fledelius W, Hjortdal J. Three-year changes in epithelial and stromal thickness after PRK or LASIK for high myopia. Invest Ophthalmol Vis Sci. 2009;50(5):2061-6.

  8. Chen WL, Shen E, Hsieh Y, Yeh PT, Wang T, Hu FR. Comparison of in vivo confocal microscopic findings between epi-LASIK procedures with different management of the epithelial flaps. Invest Ophthalmol Vis Sci. 2011;52(6):3640-7.

  9. Li J, Wang Y. Characteristics of straylight in normal young myopic eyes and changes before and after LASIK. Invest Ophthalmol Vis Sci. 2011;52(6):3069-73.

  10. Patel SV, Bourne W. Corneal endothelial cell loss 9 years after excímer láser keratorefractive surgery. Arch Ophthalmol. 2009;127(11):1423-7.

  11. Anderson NJ, Edelhauser H, Sharara N, Thompson KP, Rubinfeld RS, Devaney DM, et al. Histologic and ultrastructural findings in human corneas after successful láser in situ keratomileusis. Arch Ophthalmol. 2002;120(3):288-93.

  12. Patel DV, McGhee CN. In vivo láser scanning confocal microscopy confirms that the human corneal sub-basal nerve plexus is a highly dynamic structure. Invest Ophthalmol Vis Sci. 2008;49(8):3409-12.

  13. Nubile M, Mastropasqua L. In vivo confocal microscopy of the ocular surface: where are we now? Br J Ophthalmol. 2009;93(7):850-2.

  14. Argento C, Croxatt JO. Evaluación de la celularidad estromal corneal mediante microscopía confocal en LASEK con Mitomicina. Oftalmol Clin Exp. 2007;35(1):14-20.

  15. Erie JC, Patel SV, McLaren JW, Hodge DO, Bourne WM. Keratocyte density in the human cornea after photorefractive keratectomy. Arch Ophthalmol. 2003;121(6):770-6.

  16. Kaufman SC. How has confocal microscopy helped us in refractive surgery? Curr Opin Ophthalmol. 2006;17(4):380-8.

  17. Niederer RL, Perumal D, Sherwin T, McGhee CN. Age-related differences in the normal human cornea: a láser scanning in vivo confocal microscopy study. Br J Ophthalmol. 2007;91(9):1165-9.

  18. Pacheco C, Baca O, Velasco R. Reinervación corneal y dinámica de queratocitos posterior a queratoplastía penetrante. Reporte de casos. Rev Mex Oftalmol. 2008;82(4):263-6.

  19. Ivarsen A, Laurberg T, Møller-Pedersen T. Characterisation of corneal fibrotic wound repair at the LASIK flap margin. Br J Ophthalmol. 2003;87(10):1272-8.

  20. Holzer MP, Knorz MC, Tomalla M, Neuhann TM, Auffarth GU. Intrastromal femtosecond laser presbyopia correction: One-year results of a multicenter study. J Refract Surg. 2012;28(3):182-8.

  21. Ortiz D, Piñero D, Shabayek MH, Arnalich-Montiel F, Alió JL. Corneal biomechanical properties in normal, post-laser in situ keratomileusis, and keratoconic eyes. Br J Ophthalmol. 2007;33(8):1371-5.

  22. Stephan A, Zhivov A, Eberle F, Koehler B, Maier S, Bretthauer G, et al. Image reconstruction of the subbasal nerve plexus with in vivo confocal microscopy. Invest Ophthalmol Vis Sci. 2011;52(9):5022-8.

  23. Erie JC, McLaren JW, Hodge DO, Bourne WM. Recovery of corneal subbasal nerve density after PRK and LASIK. Am J Ophthalmol. 2005;140(6):1059-64.

  24. Benítez JM, Acosta C, Wassfi MA, Díaz-Valle D, Gegúndez JA, Fernández C, et al. Relation between corneal innervation with confocal microscopy and corneal sensitivity with noncontact esthesiometry in patients with dry eye. Invest Ophthalmol Vis Sci. 2007;48(1):173-81.

  25. Vanathi M, Tandon R, Sharma N, Titiyal JS, Pandey RM, Vajpayee RB. In-vivo slit scanning confocal microscopy of normal corneas in Indian eyes. Indian J Ophthalmol. 2003;51(3):225-30.




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