2013, Number 2
<< Back Next >>
Rev Cub Oftal 2013; 26 (2)
Behavior of malignant eyelid tumors treated at the National Institute of Oncology and Radiobiology
Melgares RMÁ, Pardo LC, Salazar RS, Silveira MY
Language: Spanish
References: 19
Page: 285-293
PDF size: 64.06 Kb.
ABSTRACT
Objective: to evaluate the clinical and histopathological behavior of malignant eyelid tumors and the treatment options followed at the National Institute of Oncology and Radiobiology.
Methods: a retrospective analysis of 255 patients consecutively treated from January 1995 to July 2010 was carried out. The cases were evaluated according to location of tumor, treatment modality, recurrence, relapse, complications and survival rate. The staging of each case followed the criteria of the International Union against Cancer such T1N0M0, T2N0M0, T3N0M0, T4N0M0.
Results: of the total number of patients, 54.1% were males and 45.9% females with age ranging 18 to 80 years. The most frequent location was the lower eyelid (35%) and the outer border, the predominant histopathological type was basocellular carcinoma (47.8%). The treatment of choice was surgery which was performed in 198 patients. In the study group, 50.2% of the treated cases showed tumoral persistence with infiltration of surgical section borders, which received adjuvant radiant treatment. Recurrences occurred in 3.5% of cases after 3 to 5 months and relapses appeared in 7.1% of patients after the first year of the end of the initial treatment. The most common complications were poor esthetic results, reduced vision, corneal ulcers and others. Survival rate was 86.3%.
Conclusions: it is necessary to implement modern and conservative treatments as alternative to surgery, which may be able to control tumor and to improve the quality of life of specific eyelid cancer cases.
REFERENCES
United States. Department of Health and Human Services. Healthy people 2010 (Conference ed.). 2 vols. Washington, DC: US Department of Health and Human Services; 2010.
Thomas VD, Aasi SZ, Wilson LD, Leffell DJ. Cancer of the skin. En: De Vita VT, Lawrence TS, Rosenberg SA, editores. De Vita, Hellman, and Rosenberg's Cancer: Principles and Practice of Oncology. 8th ed. Philadelphia, Pa: Lippincott Williams & Wilkins; 2008. p. 1863-87.
Lomas A, Leonardi-Bee J, Bath-Hextall F. A systematic review of worldwide incidence of nonmelanoma skin cancer. Br J Dermatol. 2012;166(5):1069-80.
Feig B, Berger D, Fuhrman G. The Anderson Surgical Oncology Handbook. 4th ed. Philadelphia: Lippincott & Wilkins; 2006.
Ministerio de Salud Pública. Anuario Estadístico de Cuba 2010. Dirección Nacional de Registros Médicos y Estadísticas de Salud. La Habana; 2011.
Puig M, Cordiés NE, Martínez J, Fong F. Estudio de 179 casos de tumores malignos de los párpados en el INOR. Rev Cubana Oncol. 1987;3(2):244-50.
Deprez M, Uffer S. Clinicopathological features of eyelid skin tumors. A retrospective study of 5504 cases and review of literature. Am J Dermatopathol. 2009;31(4):256-62.
Pogrzebielski A, Jedrychowska J, Adamska A, Styczyn´ska E, Romanowska-Pawliczek A, Romanowska-Dixon B. Eyelid Basal Cell Carcinoma Series of 170 Patients. Clinical and Experimental Ophthalmology. 2008;36(Sup 1):332-7.
Eusterholz T, Wenzel M. Eyelid reconstruction with Tarsomarginal transplant. Ophthalmologe. 1997;94(10):745-50.
Göppner D, Leverkus M. Basal Cell Carcinoma: From the Molecular Understanding of the Pathogenesis to Targeted Therapy of Progressive Disease. Journal of Skin Cancer. 2011;43(8):1155-63.
Haefliger IO, Tschopp M, Piffaretti JM, Pimentel AR. Delayed reconstruction after eyelid tumor excision. Klin Monbl Augenheilkd. 2012;229(4):391-4.
Gündüz K, Bita E. Expert Rev. Diagnosis and management of malignant tumors of the eyelid, conjunctiva and orbit. Ophthalmol. 2008;3(1):63-75.
Jebodhsingh KN, Calafati J, Farrokhyar F, Harvey JT. Recurrence rates of basal cell carcinoma of the periocular skin: what to do with patients who have positive margins after resection. Can J Ophthalmol. 2012;47(2):181-4.
Hata M, Koike I, Maegawa J, Kaneko A, Odagiri K, Kasuya T, et al. Radiation therapy for primary carcinoma of the eyelid: tumor control and visual function. Strahlenther Onkol. 2012;188(12):1102-7.
Engelmann V, Pfrommer S, Dridi MJ, Piening J, Lohmann CP, Merté RL.Comparison of the aesthetic outcome and complication rate of reconstructive surgical procedures of the eyelid after basalioma excision. Ophthalmologe. 2011;108(1):33-7.
McCallum DI, Kinmont PDC, Williams DW, Cotton RE, Wroughton MA. Intra-epidermal carcinoma of the eyelid margin. British Journal of Dermatology. 2006;93(3):239-52.
García E, Fernández FJ. Tendencias en el tratamientos de los carcinomas basocelulares perioculares. Arch Soc Esp Oftalmol. 2010;85(8):261-2.
Auw-Haedrich C, Frick S, Boehringer D, Mittelviefhaus H. Histologic Safety Margin in Basal Cell Carcinoma of the Eyelid. Ophthalmology. 2009;116(4):802-6.
Kotimäki J. Photodynamic therapy of eyelid basal cell carcinoma. J Eur Acad Dermatol Venereol. 2009;23(9):1083-7.