Rodríguez C, Ocampo L, López D, Solís H, Caballero S

Language: Spanish
References: 20
Page: 3-9
PDF size: 648.52 Kb.

ABSTRACT

The diagnostic value of electroencephalography (EEG) in clinical or experimental models are controversial. Because the effects produced by chemical contention will alter its in diagnostic and investigative results. Objective: this essay was directed towards to recognize the effects of chemical contention on the EEG tracings and the background activity. Material and methods: two drugs and a drug combination were chosen for this study: hydrocloride of xylazine, propofol, and thiopental-isoflurane. We work with three groups (n-15), at six times (t0, t1, t5, t10, t15, t30) particular graphic artifacts of each drug were described and the relative power was quantified. Results: each group presents particular graphic artifacts on EEG record, we seems; in thiopental-isofluorano group, all channels amplitude suppression when the isofluorano concentration was high. In propofol group we observe intermittent fast activity in frontal electrodes, and xylacine group we describe acute spike on occipital electrodes. Finally, quantitative analyses show that at t30 (thirty minutes) an equal BETA suppression was observed between the xylazine vs.propofol, and xylazine vs. thiopental-isoflurane groups (PÃ0.05). Conclusions: each drug make a different EEG graphic effect. Apparently the drug – receptor relationship make a particularly graphic artifact, but also we can observe across these results that the BETA relative power in dogs is indistinguishable among these drugs, forward about thirty minutes. This findings show that chemical contention for experimental or diagnostic EEG studies in dogs is a limited factor, but with this, if we know the EEG drugs effects, we have better quality diagnostics or experimental results.

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