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2013, Number 4

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Rev Mex Anest 2013; 36 (4)

Prevention of postoperative nausea and vomiting in patients who underwent laparoscopic cholecystectomy with ondansetron

Yado-García RO, Armendáriz-Salinas J, Valero-Gómez J, Terán-Guevara JJ, Betancourt-Márquez MD

Language: Spanish
References: 32
Page: 280-287
PDF size: 235.04 Kb.


ABSTRACT

The efficacy of preoperatory oral ondansetron was compared with ondansetron by intravenous injection during the surgery in 50 patients of laparoscopic cholecystectomy in a public hospital. The assessment of nausea and vomit was performed every 0, 2, 12 and 24 hours after the surgery. Through the T of Student, the distribution of the values was calculated using a reliability index of 95%. Also, both non parametric and parametric statistics were used in order to make inferences about the results. Consequently, a hypothesis test was applied in order to accept or reject it. Finally, the Fisher Test provided enough support to accept the hypothesis (σ = .049). Themajority of the participants were female (IV 76% and VO 84%) and denied smoking habits (IV 68% y VO 80%). As a conclusion, there were not significant differences between any of the study variables. Therefore, oral ondansetron was significantly more efficient than the intravenous ondansetron at the postoperative period of 12 hours (36% and 12%, respectively, p = 0.0378).


REFERENCES

  1. Ananth C, Somasekharam P. A comparative study of ondansetron and granisetron for prevention of nausea and vomiting following laparoscopic surgeries. . Karnataka, Bangalore: Rajiv Gandhi University of Health Sciences; 2009.

  2. East J, Mitchell D. Postoperative nausea and vomiting in laparoscopic cholecystectomy at two major Hospitals in Jamaica. West Indian Medical Journal. 2009;58:130-137.

  3. Castillo J, Fajardo P, Lozano R. Evaluación del uso del clorhidrato de ondansetrón para la prevención de náuseas y vómitos en el postoperatorio. Tesis publicada: Universidad de el Salvador: Facultad de Medicina; 2012.

  4. Anil-Gomes L. A comparison of effectiveness of two surgical units in performing laparoscopic cholecystectomy. International Journal of Health Sciences. 2008;2:85-91.

  5. Hirano Y, Watanabe T, Uchida T, Yoshida S, Tawaraya K, Kato H et al. Single incision laparoscopic cholecystectomy: single institution experience and literatura review. World Journal Gastroenterology January. 2010;16:270-274.

  6. Lucena J. Náuseas y vómitos post colecistectomía laparoscópica [Internet]. Caracas, Venezuela. Facultad de Medicina Universidad de Venezuela. 2011. Disponible en: http://caibco.ucv.ve/caibco/vitae/VitaeDieciocho/Articulos/Cirugia/ArchivosPDF/cirugia.pdf

  7. Piña C, Grimblatt C. Prevención de náuseas y vómitos postoperatorios: ondansetrón versus metoclopramida. Memorias del 32° Congreso Argentino de Anestesiología. Mendoza, Argentina: 2003.

  8. Oriol LS, Arzate GP, Hernández BC, Castelazo AJ. ¿Ondansetrón o dexametasona? Tratamiento de náusea y vómito postoperatorios en cirugía abdominal. Revista Mexicana de Anestesiología. 2009;32:163-170.

  9. Alonso DE, Anguiano GM. Aprepitant contra ondansetrón en la prevención de náusea y vómito postoperatorio en pacientes de colecistectomía abierta. Revista Mexicana de Anestesiología. 2012M;35:8-14.

  10. Ochoa C, Orejón G. Una dosis de ondansetrón para reducir los vómitos en pacientes con gastroenteritis aguda. Evidencias en Pediatría. 2008;4:73.

  11. Sabistón D. Tratado de patología quirúrgica. Vol. 1 y 2. 15ª ed. México: McGraw-Hill Interamericana; 1999.

  12. Steinbrook R, Freiberger D, Gosnell J, Brooks D. Prophylactic antiemetics for laparoscopic cholecystectomy: ondansetron versus droperidol plus metoclopramide. Anesthesia & Analgesia. 1996;83:1181-1183.

  13. Bel Marcoval I, Gambus CP. Estratificación del riesgo, profilaxis y tratamiento de las náuseas y vómitos postoperatorios. Revista Española de Anestesiología y Reanimación. 2006;53:301-311.

  14. Gupta V, Wakloo R, Mehta A, Dev-Gupta S. Prophylactic antiemetic therapy with ondansetron, granisetron and metoclopramide in patients of laparoscopic cholecystectomy. Journal of Medical Education and Research. 2006;10:74-77.

  15. Gang T. Risk factors for postoperative nausea and vomiting. Anesthesia and Analgesia. 2006;102:1884-1898.

  16. Habib A, Gang T. Evidence based management of post-operative nausea and vomiting. A review. Canadian Journal of Anesthesiology. 2004;51:326-341.

  17. Penciua M, D’Agostino R, Vasan R. Evaluating the added predictive ability of a new marker: frontal area under the ROC curve to reclassification and beyond. Statistical Medicine. 2004;27:157-172.

  18. Apfel C, Kranke P, Eberhart L, Roos A, Roewer M. Comparison of predictive models for postoperative nausea and vomiting. British Journal of Anaesthesiology. 200288:234-240.

  19. Apfel C, Laara E, Koivuranta M, Greim C, Roewer M. A simplified risk score for predicting postoperative nausea and vomiting: conclusions from cross-validations between two centers. Anesthesiology. 1999;91:693-700.

  20. Eberhart L, Geldner G, Kranke P, Morin A, Schauffelen A, Treiber H. The development and validation of a risk score to predict the probability of postoperative nausea and vomiting in pediatric patients. Anesthesia and Analgesia. 2004;99:1630-1637.

  21. Apfel C, Korttila K, Abdalla M, Kerger H, Turan A, Vedder I. A factorial trial of six interventions for the prevention of postoperative nausea and vomiting. New England Journal of Medicine. 2004;350:2441-2451.

  22. Ruiz J, Kee S, Frenzel J, Ensor J, Selvan M, Riedel B. The effect of an anatomically classified procedure on antiemetic administration in the postanesthesia care unit. Anesthesia and Analgesia. 2010;110:403-409.

  23. Habib A, Gang T. Postoperative nausea and vomiting database research. Limitations and opportunities. Anesthesia and Analgesia. 2010;412-414.

  24. White P. Prevention of postoperative nausea and vomiting. Multimodal solution to a persistent problem. New England Journal of Medicine. 2004;350:2511-2512.

  25. D’Angelo R, Philip B, Gang T, Kovac A, Hantler C, Doblar D. A randomized, double-blind, close-ranging, pilot study of intravenous granisetron, in the prevention of postoperative nausea and vomiting in patients abdominal hysterectomy. European Journal of Anaesthesiology. 2005;22:774-779.

  26. Henzi I, Walder B, Tramer M. Dexamethasone for the prevention of postoperative nausea and vomiting. A quantitative systematic review. Anesthesiology and Analgesia. 2000;90:186-194.

  27. Gang T, Meyer T, Apfel C, Chung F, Davis F, Habib A. Society for ambulatory anesthesia guidelines for the management of post-operative nausea and vomiting. Anesthesia and Analgesia. 2007;105:1615-1628.

  28. Henzi I, Walder B, Tramer M. Metoclopramide in the prevention of postoperative nausea and vomiting. A quantitative systematic review of randomized, placebo-controlled studies. British Journal of Anaesthesiology. 1999;83:761-71.

  29. Silverstein J, Apfelbaum J, Barlow J, Chung F, Connis R, Filmore R. Practical guidelines for postanesthetic care. Anesthesiology. 2002;96:742-752.

  30. Tramer M, Moore R, Reynolds D, Mc Quay H. A quantitative systematic review of ondansetron in treatment of established postoperative nausea and vomiting. British Medicine Journal. 1997;314:1088-1092.

  31. Habib A, Gang T. The effectiveness of rescue antiemetics after failure of prophylaxis with ondansetron or droperidol: a preliminary report. Journal of Clinical Anesthesiology. 2005;17:62-65.

  32. Secretaría de Salud. Reglamento de la Ley General de Salud en Materia de Investigación para la salud. 7a ed. México: Editorial Porrúa; 1987.




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